A higher intake of foods rich in flavonoids such as quercetin can reduce the risk of cardiovascular disease. Enzymatically modified isoquercitrin (EMIQ®) has a bioavailability 17-fold higher than quercetin aglycone and has shown potential cardiovascular disease moderating effects in animal studies. The present study aimed to determine if acute ingestion of EMIQ® improves endothelial function, blood pressure, and cognitive function in human volunteers at risk of cardiovascular disease. Twenty-five participants (12 males, 13 females) with at least one cardiovascular disease risk factor completed this randomized, controlled, crossover study. In a random order, participants were given EMIQ® (2 mg aglycone equivalent)/kg body weight or placebo alongside a standard breakfast meal. Endothelial function, assessed by flow mediated dilatation (FMD) of the brachial artery was measured before and 1.5 hrs after intervention. Blood pressure (BP), arterial stiffness, cognitive function, BP during cognitive stress and measures of quercetin metabolites, oxidative stress and markers of nitric oxide (NO) production were assessed post-intervention. After adjustment for pre-treatment measurements and treatment order, EMIQ® treatment resulted in a significantly higher FMD response compared to the placebo [0.60%, 95% CI: 0.03, 1.17 (p=0.04)]. Plasma concentrations of quercetin metabolites were significantly higher (p<0.001) after EMIQ® treatment compared to the placebo. No changes in blood pressure, arterial stiffness, cognitive function, or biochemical parameters were observed. In this human intervention study, the acute administration of EMIQ® significantly increased circulating quercetin metabolites and improved endothelial function. Further clinical trials are required to assess whether health benefits are associated with long-term EMIQ® consumption.

Space Infrared Telescope for Cosmology and Astrophysics (SPICA), the cryogenic infrared space telescope recently pre-selected for a ‘Phase A’ concept study as one of the three remaining candidates for European Space Agency (ESA's) fifth medium class (M5) mission, is foreseen to include a far-infrared polarimetric imager [SPICA-POL, now called B-fields with BOlometers and Polarizers (B-BOP)], which would offer a unique opportunity to resolve major issues in our understanding of the nearby, cold magnetised Universe. This paper presents an overview of the main science drivers for B-BOP, including high dynamic range polarimetric imaging of the cold interstellar medium (ISM) in both our Milky Way and nearby galaxies. Thanks to a cooled telescope, B-BOP will deliver wide-field 100–350 $\mu$ m images of linearly polarised dust emission in Stokes Q and U with a resolution, signal-to-noise ratio, and both intensity and spatial dynamic ranges comparable to those achieved by Herschel images of the cold ISM in total intensity (Stokes I). The B-BOP 200 $\mu$ m images will also have a factor $\sim $ 30 higher resolution than Planck polarisation data. This will make B-BOP a unique tool for characterising the statistical properties of the magnetised ISM and probing the role of magnetic fields in the formation and evolution of the interstellar web of dusty molecular filaments giving birth to most stars in our Galaxy. B-BOP will also be a powerful instrument for studying the magnetism of nearby galaxies and testing Galactic dynamo models, constraining the physics of dust grain alignment, informing the problem of the interaction of cosmic rays with molecular clouds, tracing magnetic fields in the inner layers of protoplanetary disks, and monitoring accretion bursts in embedded protostars.

In the Iliad the Achaean ships play a prominent role in the narrative; they are foregrounded as Achilles sits by his vessels in anger and threatens to sail home; as the Trojans come close to burning them; and as Hector's body lies by Achilles’ ships until ransomed. Where not in the foreground, the ships remain a consistent background; without them the Achaeans would not have reached Troy; they are an essential component of the Greek encampment; and are the unrealized potential vehicle of the Achaean homecoming.

Evaluation was not a thing when the first author was a graduate student in the late 1970s. There was an Artificial Intelligence (AI) boom then, but that boom was quickly followed by a bust and a long AI Winter. Charles Wayne restarted funding in the mid-1980s by emphasizing evaluation. No other sort of program could have been funded at the time, at least in America. His program was so successful that these days, shared tasks and leaderboards have become common place in speech and language (and Vision and Machine Learning). It is hard to remember that evaluation was a tough sell 25 years ago. That said, we may be a bit too satisfied with current state of the art. This paper will survey considerations from other fields such as reliability and validity from psychology and generalization from systems. There has been a trend for publications to report better and better numbers, but what do these numbers mean? Sometimes the numbers are too good to be true, and sometimes the truth is better than the numbers. It is one thing for an evaluation to fail to find a difference between man and machine, and quite another thing to pass the Turing Test. As Feynman said, “the first principle is that you must not fool yourself–and you are the easiest person to fool.”

In Breaking the Pendulum: The Long Struggle Over Criminal Justice (2017), Philip Goodman, Joshua Page, and Michelle Phelps advocate replacing the pendular notion of penal change with an agonistic approach, where contention is central. This Essay reflects on a pendulum component that has escaped theoretical or empirical scrutiny in pendular accounts of penal change: the pivot determining how freely a pendulum weight swings, and its resting equilibrium. In this parting glance at the pendulum heuristic, I relate this pivot to the agonistic perspective on punishment and—focusing on racial politics of juvenile justice—imagine an antiracist calibration of struggle over penal change.

The Very High Frequency (VHF) Data Exchange System (VDES) is a new radio communication system being developed by the international maritime community, with the principal objectives to safeguard existing Automatic Identification System (AIS) core functions and enhance maritime communication applications, based on robust, efficient and secure data transmission with wider bandwidth than the AIS. VDES is also being considered as a potential component of the R-mode concept, where the same signals used for communication are also used for ranging, thus mitigating the impact of disruptions to satellite positioning services. This paper establishes statistical performance bounds on the ranging precision of VDES R-mode, assuming an additive white Gaussian noise propagation channel. Modified Cramér-Rao bounds on the pseudorange estimation error are provided for all waveforms currently proposed for use in terrestrial VDES communications. These are then used to estimate the maximum usable ranges for AIS/VDES R-mode stations. The results show that, under the assumed channel conditions, all of the new VDES waveforms provide better ranging performance than the AIS waveform, with the best performance being achieved using the 100 kHz bandwidth terrestrial VDE waveforms.