Subcutaneous adipose tissue (scAT) and peripheral blood mononuclear cells (PBMCs) play a significant role in obesity-associated systemic low-grade inflammation. High-fat diet (HFD) is known to induce inflammatory changes in both scAT and PBMCs. However, the time course of the effect of HFD on these systems is still unknown. The aim of the current study was to determine the time course of the effect of high fat diet (HFD) on PBMCs and scAT. New Zealand white rabbits were fed HFD for 5 or 10 weeks (i.e., HFD-5 and HFD-10), or regular chow (i.e., CNT-5 and CNT-10). Thereafter, metabolic and inflammatory parameters of PBMCs and scAT were quantitated. HFD induced hyperfattyacidemia in HFD-5 and HFD-10 groups, with the development of insulin resistance (IR) in HFD-10, while no changes were observed in scAT lipid metabolism and inflammatory status. HFD activated the inflammatory pathways in PBMCs of HFD-5 group, and induced modified autophagy in that of HFD-10. The rate of fat oxidation in PBMCs was directly associated with the expression of inflammatory markers; and tended to inversely associate with autophagosome formation markers in PBMCs. HFD affected systemic substrate metabolism, and the metabolic, inflammatory, and autophagy pathways in PBMCs in the absence of metabolic and inflammatory changes in scAT. Dietary approaches or interventions to avert HFD-induced changes in PBMCs could be essential in prevention of metabolic and inflammatory complications of obesity, and promote healthier living.

The historiography on colonial petitioning has primarily construed it as an authorized ritual of supplication designed to affirm and reproduce established power relations. This article restores to the analysis of the petition its status as a potential ‘event’ that could exceed its documentary confines and generate new communities of action. Focusing specifically on colonial Bombay, circa 1889–1914, it highlights three ways in which petitioning marked a rupture in the relations between rulers and ruled, and heralded significant shifts in the local constructions of state and society. First, the article shows how Bombay's Indian residents deployed the petitioning process to contest the unprecedented degree of state intervention in their quotidian lives following an extraordinary civic crisis that engulfed the city in the last decade of the Victorian era. Secondly, the article contends that the petitions that ordinary Indians in Bombay submitted to the different agencies of urban government point to a more complex set of orientations to the colonial state than has been acknowledged by scholars. Thirdly, the article argues that by the end of the nineteenth century, collective petitioning in colonial Bombay had become embedded in forms of political action with which it is conventionally regarded as being incompatible.

Bombay, the hub of Britain's Indian Ocean empire, hosted a ceaseless flow of humanity: sailors and lawyers, street performers and royal refugees. When fate set obstacles in their way, the residents of this teeming metropolis petitioned colonial officials, looking on them as patriarchal providers of last resort. These petitions, which this article terms ‘personal pleas’, adeptly braided different, often contradictory, idioms of late nineteenth- and early twentieth-century imperial governance, from stylized imitations of traditional authority to bureaucratic proceduralism. Their functional contribution to Raj governance, however, remains a puzzle since the vast majority of petitions were rejected. For the British, the steady flow of rejections threatened to unmask the disjuncture between the expectations and realities of Raj paternalism. As a result, colonial officials viewed personal pleas with a mixture of ridicule and concern. Yet, while unsettling for officials, personal pleas rarely spurred the collective politics associated with anti-colonial resistance. Thus, where other articles in this special issue focus on petitioning's functional contributions to the consolidation of state bureaucracies and the formation of new publics, this article traces the genre's more emotive dimensions. Even as they failed to consolidate colonial discipline or resistance, personal pleas provided a vehicle for the airing of the lived contradictions and tensions of empire. They allowed rulers and subjects alike to fantasize about the possibility of a more benevolent order, and to vent their frustration when those fantasies crumbled in the face of imperial indifference.

This article explores the role of Indian petitioning in the process of consolidating British power after the East India Company's military conquest of Bengal in the late eighteenth century. The presentation of written petitions (often termed ‘arzi in Persian) was a pervasive form of state-subject interaction in early modern South Asia that carried over, in modified forms, into the colonial era. The article examines the varied uses of petitioning as a technology of colonial state-formation that worked to establish the East India Company's headquarters in Calcutta as the political capital of Bengal and the Company as a sovereign source of authority and justice. It also shows how petitioning became a site of anxiety for both colonial rulers and Indian subjects, as British officials struggled to respond to a mass of Indian ‘complaints’ and to satisfy the expectations and norms of justice expressed by petitioners. It suggests that British rulers tried to defuse the perceived political threat of Indian petitioning by redirecting petitioners into the newly regulated spaces of an emergent colonial judiciary.

In recent years, petitioning cultures have attracted scholarly interest because they are seen as germane to the infrastructure of political communication and modern associative life. Using materials from early colonial Madras, this article discloses a trajectory of the appeal which is different from its conventional place in the social theory of political communication. Colonial petitions carried with them the idea of law as equity through which a paternalist government sought to shape a consenting subject, even as this sense of equity was layered by other meanings of justice. In this sense petitions reworked and exceeded the idioms of imperial law and justice. Thus two aspects of the colonial petition are the focus of this article: its genealogies in the institutional history of the early modern corporation that transmitted notions of law as equity, and the recursive and heteroglossic nature of the language of appeal that enabled this text-form to be an enduring site for refashioning terms of address.

This article explores the entwined history of early colonial urbanism and the articulation of legal subjectivity under East India Company rule in South India. More specifically, it looks at petitions from outcaste labouring groups to the Madras government in the late eighteenth and early nineteenth centuries. Although early colonial petitions were unequivocally products of colonial rule, which derived their distinctive form and language from colonial law, a reading of the petition archive is one of the only ways to achieve a historical understanding of the city of Madras as it was experienced by its less privileged inhabitants. This article looks at the delineation of the communal selfhood of subaltern urban communities through petition narratives, arguing that the variety and innovativeness displayed by petition writers is testament both to the acceptance of colonial legality and to the agency of native subjects in negotiating with, and appropriating the language and rationale of, the colonial legal regime.

Cows have been the subject of political petitioning in South Asia for over a hundred years. This article examines the changing relationship between communities and the state in India through the transformation of petitioning practices—from ‘monster’ petitions, to postcard campaigns and constitutional writs—by the proponents and opponents of the cow protection movement from the late nineteenth century through to the first decades of independence. The article shows that, instead of disciplining and formalizing popular politics, petitioning provides channels for mobilization and disruption. As Hindus and Muslims engaged in competitive petitioning to rally a public, persuade the executive, or litigate through the courts, the question of cow slaughter was recast from one of community representation to religious belief, to property rights, to federalism, and, finally, questions of national economic development. In the absence of representative government in colonial India, Hindus for cow protection generated massive petitions which argued that they represented popular democratic will. Despite the lack of a constitution, Muslim petitioners sought to establish a judicially enforceable framework to protect their right to cow slaughter. Independence, which brought both democracy and a written constitution, caused a fundamental break with older claims and forms of petitioning, and led to both Hindus and Muslims seeking to settle the debate through writ petitions before constitutional courts.

On 4 May 2014, as a tumultuous general election in India drew to a close, the Indian Express newspaper published a column by Tavleen Singh, with the headline ‘No more petitioners: no more petitioners’. The column went on to quote P. Chidambaran, the outgoing finance minister of the defeated Congress government, who diagnosed a historical shift in the mentality of the Indian electorate. ‘India has moved on,’ Chidambaran was reported as saying, ‘from a petitioner society to an aspirational one. Treating people as petitioners is a mistake . . . even the poor demand a better life and are no longer resigned to their fate.’ In India, the column argued, ‘poor people’ now had ‘middle class aspirations’, desiring ‘jobs and development’ rather than ‘charity’ and that this was a major reason for the success of Narendra Modi and his Bharatiya Janata Party (BJP) in the 2014 elections. To be a ‘petitioner’, in this analysis, was to be ground down by poverty and resignation, and dependent on the ‘charity’ of others. It was a passing historical condition, a sign of underdevelopment that could be sloughed off by the sudden awakening across society of ‘middle class aspirations’.

This article uses a 1741 testimonial document from Kol (present-day Aligarh) to explore the workings of petitions in the local politics of the late Mughal empire. I suggest that even solitary documents such as this can be read as artefacts of the continuing processes of local politics which operated in excess of the administrative logic of the Mughal state. After surveying the place of petitions in the Mughal apparatus of justice from an administrative perspective, I examine the story of a vanished artisan named Hira to demonstrate that even scattered documents from the Mughal archive can reveal traces of the larger political processes of which a petition might be a single example. In this light, I demonstrate how the testimonial at hand can illuminate the everyday workings of the social and political order of the locality, and its relationship with larger structures of ideology and state power in an era of political decentralization.

In a political culture that experiences inordinately high levels of petitioning, what makes for a successful petition? This article studies petitions that have been efficacious in their appeals to capture or kill big cats in Himalayan India. The rates of success for any appeal against big cats are low in contemporary India, given the stringent legal regime that is geared almost exclusively towards the protection of the charismatic and endangered big cats as well as the hegemonic position occupied by wildlife conservationism. Furthermore, not only is it difficult to petition against cossetted big cats, but it is also not an easy task for any petition to be heard and acquiesced to. Through an ethnography of efficacious petitions, this article makes three related interventions. First, and in the process of attending to the rarity of a handful of efficacious petitions, this article argues for expanding our conceptualization of what, in practice, a petition is. It does so by outlining the changing forms of efficacious petitions, which can range from a telephone call, a register entry, a WhatsApp message from a smart phone, to the more ‘traditional’ paper-based petition. Beyond its ever-evolving medium, this article demonstrates the criticality of folding petitioning into a wider process that involves planning, performance, perseverance, repetition, and the capacity to elicit visceral responses. Finally, through an ethnographic foregrounding of human-big cat interactions, it demonstrates how an acceptance and elaboration of animal agency enriches the study of politico-legal processes.

British observers of the nineteenth-century panchayat were convinced that it represented a judicial forum of great antiquity, in which petitioners were able to gain local and direct access to justice. They contrasted the panchayat favourably with the delays and frustrations that beset the eighteenth-century East India Company's attempts to channel all petitions through its own courts. This article examines the history of the pre-colonial panchayat in western India and its early modern predecessors. During the early modern centuries, a diverse array of state-level and local corporate bodies made up the landscape for the submission of petitions and the hearing of suits. Although many suits were local in nature, the process of hearing and adjudication itself gave these judicial spaces a significant ‘public’ dimension, and their forms of argumentation frequently invoked general principles of justice and moral order. From the early eighteenth century, the new form of the panchayat came to supersede these older corporate bodies and to reshape the forms of public that gathered around them. The Maratha state, based in Pune, sought firmer control over revenue and justice. State officials promoted the panchayat as a new type of judicial arena, weakening the local corporate institutions and tying them more closely to the Pune court.

Between the 1970s and 1990s, political scientists in the United States pursued a distinctive research program that employed ethnographic methods to study micro politics in criminal courts. This article considers the relevance of this concept for court researchers today through a case study about bail decision making in a lower criminal court in Australia. It describes business as usual in how decisions are made and the provision of pretrial services. It also looks at how traditionalists and reformers understood business as usual, and uses this as a critical concept to make visible micro politics in this court. The case study raises issues about organizational change in criminal courts since the 1990s, since there are fewer studies about plea bargaining and more about specialist or problem-solving courts. It is suggested that we need a new international agenda that can address change and continuity in criminal courts.

Morelli, Potosky, Arthur, and Tippins (2017) make a timely and appropriate call for authors to create conceptual models of technology in industrial-organizational (I-O) psychology. We agree with their call, but we believe that Morelli et al. overlooked the contributions of related fields that conduct research on technology in the workplace that are already consistent with their call. For this reason, we briefly detail other fields that commonly study the dynamics of technology and its influence on the workplace, followed by a discussion regarding the place of I-O psychology in the broader scheme of technology research. This discussion can aid future authors in conceptualizing appropriate contributions to the study of technology in I-O psychology as well as identifying whether these contributions benefit other fields. Perhaps more importantly, this discussion can help identify where I-O psychology fits in the broader scheme of technology research and which associated fields may be most readily available to aid in the creation of new models—two questions that currently seem unanswered.

The incident command system (ICS) provides a common structure to control and coordinate an emergency response, regardless of scale or predicted impact. The lessons learned from the application of an ICS for large infectious disease outbreaks are documented. However, there is scant evidence on the application of an ICS to manage a local multiagency response to a disease cluster with environmental health risks. The Sydney Local Health District Public Health Unit (PHU) in New South Wales, Australia, was notified of 5 cases of Legionnaires’ disease during 2 weeks in May 2016. This unusual incident triggered a multiagency investigation involving an ICS with staff from the PHU, 3 local councils, and the state health department to help prevent any further public health risk. The early and judicious use of ICS enabled a timely and effective response by supporting clear communication lines between the incident controller and field staff. The field team was key in preventing any ongoing public health risk through inspection, sampling, testing, and management of water systems identified to be at-risk for transmission of legionella. Good working relationships between partner agencies and trust in the technical proficiency of environmental health staff aided in the effective management of the response. (Disaster Med Public Health Preparedness. 2018;12:539–542)

Natural resources in and around protected areas in many countries in Africa are under intense pressure as a result of illegal behaviour, such as fishing, hunting and logging. A better understanding of local people's perceptions of the nature of illegal behaviour and the relevance of conservation actions would be useful in informing conservation decisions. We gathered information on the attitudes and perceptions of communities in the vicinity of Ugalla Game Reserve in western Tanzania regarding illegal behaviour and the effectiveness of conservation practices, using household surveys, key informants, and focus groups. We found that local people use the Reserve illegally, especially for hunting (28 ± SE 6%) and logging (20 ± SE 5%). We explored behaviours that are problematic for conservation in the partially protected areas around Ugalla. Local communities reported feeling isolated, harassed and intimidated by approaches used to protect Ugalla. They were angered by the conservation of Ugalla as a trophy hunting site for foreigners, and the excessive force and beatings used by game rangers to keep them away from the Reserve. Improving local livelihoods (17%), participatory conservation (16%), and giving people land for agricultural activities (16%) were among the ways that local communities felt would reduce illegal activities. Our findings suggest the need for conservation measures to benefit local communities around Ugalla transparently and equitably. Outreach programmes would help to raise conservation awareness and attract positive attitudes towards conservation. To encourage local support for conservation, we also suggest that conservation authorities create and maintain good relations with people living near the Reserve.

A new CRESU experiment devoted to neutral-neutral chemistry at low temperature is being built. The first reactions to be studied are N+NO and CN+O2.