This work investigates how turbulence in open-channel flows is altered by the passage of surface waves by using experimental data collected with laboratory tests in a large-scale flume facility, wherein waves followed a current. Flow velocity data were measured with a laser Doppler anemometer and used to compute profiles of mean velocity and Reynolds stresses, and pre-multiplied spectra. The velocity signal containing contributions from the mean flow, wave motion and turbulence was decomposed using the empirical mode decomposition (EMD), which is considered a promising tool for the analysis of velocity time series measured in complex flows. A novel outer length scale $h_{0}$ is proposed which separates the flow into two regions depending on the competition between the vertical velocities associated with the wave motion and the turbulent velocities imposed by the current. This outer length scale allows for the identification of a genuine overlap layer and an insightful scaling of turbulent statistics in the current-dominated flow region (i.e. $y/h_{0} < 1$). As the wave contribution to the vertical velocity increases, the pre-multiplied spectra reveal two intriguing features: (i) in the current-dominated flow region, the very large-scale motions (VLSMs) are progressively weakened but attached eddies are still present; and (ii) in the wave-dominated flow region (i.e. $y/h_{0} > 1$), a new spectral signature associated with long turbulent structures (approximately 6 and 25 times the flow depth $h$) appears. These longitudinal structures present in the wave-dominated flow region seem to share many features with Langumir-type cells.

Scale interaction is studied in wall-bounded turbulence by focusing on the frequency modulation (FM) mechanism of the large scales on small-scale velocity fluctuations. Different from the analysis of amplitude modulation (AM), FM has been less investigated owing to the difficulty of developing robust tools for broadband signals. To tackle this issue, the natural visibility graph approach is proposed in this work to map the full velocity signals into complex networks. We show that the network degree centrality is able to capture the signal structure at local scales directly from the full signal, thereby quantifying FM. Velocity signals from numerically-simulated turbulent channel flows and an experimental turbulent boundary layer are investigated at different Reynolds numbers. A correction of Taylor's hypothesis for time series is proposed to overcome the overprediction of near-wall FM obtained when local mean velocity is used as the convective velocity. Results provide network-based evidence of the large-to-small FM features for all the three velocity components in the near-wall region, with a reversal mechanism emerging far from the wall. Additionally, scaling arguments, in view of the quasi-steady quasi-homogeneous hypothesis, are discussed, and a delay time between the large and small scales is detected that is very close to the characteristic time of the near-wall cycle. Results show that the visibility graph is a parameter-free tool that turns out to be effective and robust to detect FM in different configurations of wall-bounded turbulent flows. Based on the present findings, the visibility network-based approach can represent a reliable tool to systematically investigate scale interaction mechanisms in wall-bounded turbulence.

OBJECTIVES/GOALS: Many clinical prediction models have been developed to guide tuberculosis (TB) treatment, but their results and methods have not been formally evaluated. We aimed to identify and synthesize existing models for predicting TB treatment outcomes, including bias and applicability assessment. METHODS/STUDY POPULATION: Our review will adhere to methods that developed specifically for systematic reviews of prediction model studies. We will search PubMed, Embase, Web of Science, and Google Scholar (first 200 citations) to identify studies that internally and/or externally validate a model for TB treatment outcomes (defined as one or multiple of cure, treatment completion, death, treatment failure, relapse, default, and lost to follow-up). Study screening, data extraction, and bias assessment will be conducted independently by two reviewers with a third party to resolve discrepancies. Study quality will be assessed using the Prediction model Risk Of Bias Assessment Tool (PROBAST). RESULTS/ANTICIPATED RESULTS: Our search strategy yielded 6,242 articles in PubMed, 10,585 in Embase, 10,511 in Web of Science, and 200 from Google Scholar, totaling 27,538 articles. After de-duplication, 14,029 articles remain. After screening titles, abstracts, and full-text, we will extract data from relevant studies, including publication details, study characteristics, methods, and results. Data will be summarized with narrative review and in detailed tables with descriptive statistics. We anticipate finding disparate outcome definitions, contrasting predictors across models, and high risk of bias in methods. Meta-analysis of performance measures for model validation studies will be performed if possible. DISCUSSION/SIGNIFICANCE OF IMPACT: TB outcome prediction models are important but existing ones have not been rigorously evaluated. This systematic review will synthesize TB outcome prediction models and serve as guidance to future studies that aim to use or develop TB outcome prediction models.

We describe system verification tests and early science results from the pulsar processor (PTUSE) developed for the newly commissioned 64-dish SARAO MeerKAT radio telescope in South Africa. MeerKAT is a high-gain ( ${\sim}2.8\,\mbox{K Jy}^{-1}$ ) low-system temperature ( ${\sim}18\,\mbox{K at }20\,\mbox{cm}$ ) radio array that currently operates at 580–1 670 MHz and can produce tied-array beams suitable for pulsar observations. This paper presents results from the MeerTime Large Survey Project and commissioning tests with PTUSE. Highlights include observations of the double pulsar $\mbox{J}0737{-}3039\mbox{A}$ , pulse profiles from 34 millisecond pulsars (MSPs) from a single 2.5-h observation of the Globular cluster Terzan 5, the rotation measure of Ter5O, a 420-sigma giant pulse from the Large Magellanic Cloud pulsar PSR $\mbox{J}0540{-}6919$ , and nulling identified in the slow pulsar PSR J0633–2015. One of the key design specifications for MeerKAT was absolute timing errors of less than 5 ns using their novel precise time system. Our timing of two bright MSPs confirm that MeerKAT delivers exceptional timing. PSR $\mbox{J}2241{-}5236$ exhibits a jitter limit of $<4\,\mbox{ns h}^{-1}$ whilst timing of PSR $\mbox{J}1909{-}3744$ over almost 11 months yields an rms residual of 66 ns with only 4 min integrations. Our results confirm that the MeerKAT is an exceptional pulsar telescope. The array can be split into four separate sub-arrays to time over 1 000 pulsars per day and the future deployment of S-band (1 750–3 500 MHz) receivers will further enhance its capabilities.

This paper investigates the existence and scaling of the so-called large-scale and very-large-scale motions (LSMs and VLSMs) in non-uniform turbulent open-channel flows developing over a smooth bed in a laboratory flume. A laser Doppler anemometry system was employed to measure vertical profiles of longitudinal and bed-normal velocity statistics over a wide range of hydraulic conditions. Pre-multiplied spectra of the longitudinal velocity fluctuations revealed the existence of two peaks occurring at wavelengths consistent with those associated with LSMs and VLSMs as detected in the past literature pertaining to wall turbulence. However, contrary to so-called canonical wall flows (i.e. flat-plate boundary layers, pipe and closed-channel flows), the LSM and VLSM peaks observed in the open-channel flows investigated herein are detectable over a much larger extent of the wall-normal coordinate. Furthermore, the VLSM peak appears at von Kármán numbers $Re_{\unicode[STIX]{x1D70F}}$ as low as 725, whereas in other wall flows much higher values are normally required. Finally, as conjectured by a recent study on uniform rough-bed open-channel flows, the present paper confirms that LSM wavelengths scale nicely with the flow depth, whereas the channel aspect ratio (i.e. the ratio between channel width and flow depth) is the non-dimensional parameter controlling the scaling of VLSM wavelengths. The intensity and wavelengths of the VLSM peaks were also observed to depend on the spanwise coordinate. This result suggests that VLSMs might be dynamically linked to secondary currents, as these are also known to vary in strength and size across the channel width.

Evidence of an early modern “Little divergence” in real wages between northwestern Europe and the rest of the continent is mostly based on the comparative study of a sample of leading European cities. Focusing on France and England this study reassesses the debate from a country-level perspective. The findings challenge the notion of an early modern divergence pointing to the coexistence of both divergence and convergence phases until the eighteenth century. Results also suggest that the real wages of a significant share of the French male labor force were broadly on par with the levels prevailing in England before c.1750.

A temporal complex network-based approach is proposed as a novel formulation to investigate turbulent mixing from a Lagrangian viewpoint. By exploiting a spatial proximity criterion, the dynamics of a set of fluid particles is geometrized into a time-varying weighted network. Specifically, a numerically solved turbulent channel flow is employed as an exemplifying case. We show that the time-varying network is able to clearly describe the particle swarm dynamics, in a parametrically robust and computationally inexpensive way. The network formalism enables us to straightforwardly identify transient and long-term flow regimes, the interplay between turbulent mixing and mean flow advection and the occurrence of proximity events among particles. Thanks to their versatility and ability to highlight significant flow features, complex networks represent a suitable tool for Lagrangian investigations of turbulent mixing. The present application of complex networks offers a powerful resource for Lagrangian analysis of turbulent flows, thus providing a further step in building bridges between turbulence research and network science.

Weakly peralkaline syenite ejecta within the plinian fall deposits of Agua de Pau volcano (São Miguel, Azores Islands) are divisible into (1) silica-undersaturated and (2) silica-saturated/oversaturated groups. The first group occurs in the pre-Fogo-A pyroclastic falls (15.2 ka) whereas the second occurs in the Fogo-A pumices (5 ka). The petrography indicates that the syenites of both groups crystallized at shallow depths and whole-rock geochemistry shows that they have compositions reflecting those of the Agua de Pau trachyte magmas. The syenites are inferred to be derived from solidification zones around the margins of the parental magma chamber. Mineral parageneses in both syenite groups permit distinction of three magmatic stages of crystallization: (1) an early crystallization stage; (2) a main crystallization stage during which most of the feldspar growth occurred; and (3) a late interstitial stage. Crystallization of the trachytic magmas yielded peralkaline residuals, highly enriched in volatiles, alkalis, HFSE and REE. In the silica-undersaturated syenites, the complex Zr-Ti silicate minerals, eudialyte and a låvenite-like mineral, crystallized interstitially from the residual magmas. In contrast, the zircono-silicate dalyite, and REE-rich minerals (chevkinite-(Ce), britholite-(Ce) and pyrochlore), together with thorite, were late-stage interstitial products of the silica-saturated/oversaturated syenites.

Multi-decade observing campaigns of the globular clusters 47 Tucanae and M15 have led to an outstanding number of discoveries. Here, we report on the latest results of the long-term observations of the pulsars in these two clusters. For most of the pulsars in 47 Tucanae we have measured, among other things, their higher-order spin period derivatives, which have in turn provided stringent constraints on the physical parameters of the cluster, such as its distance and gravitational potential. For M15, we have studied the relativistic spin precession effect in PSR B2127+11C. We have used full-Stokes observations to model the precession effect, and to constrain the system geometry. We find that the visible beam of the pulsar is swiftly moving away from our line of sight and may very soon become undetectable. On the other hand, we expect to see the opposite emission beam sometime between 2041 and 2053.

The linearly polarized component of a pulsar signal at different radio frequencies can help to constrain the parallel component of the magnetic field along the line of sight. In this work we measured the polarimetric properties of the pulsars in the globular cluster 47 Tucanae and we report the Rotation Measure (RM) for 13 of them. A gradient in the RM values of the pulsars across the cluster is detected suggesting the presence of significant variations in the magnetic field across the very small angular scales associated with the lines of sight to the pulsars in 47 Tucanae. Both magnetic fields located in the globular cluster or in the Galactic disk in the direction of the cluster are taken into consideration. However, more detailed modelling of the dynamics of the cluster and deeper observations with the MeerKAT and/or the SKA1 radio telescopes are necessary to discriminate among the models.

The Sardinia Radio Telescope (SRT) is a modern, fully-steerable 64-m dish located in San Basilio, Sardinia (Italy). It is characterized by an active surface that allows it to cover a wide range of radio frequencies (300 MHz to 100 GHz). During SRT’s commissioning phase, we installed the hardware and software needed for pulsar observations. Since then, SRT has taken part in Large European Array for Pulsars and European Pulsar Timing Array observations for the purpose of gravitational wave detection. We have installed a new S-band receiver that will allow us to search for pulsars in the Galactic Center. We also plan to combine our efforts to search for Extraterrestrial Intelligence (SETI) with the search for pulsars and Fast Radio Bursts.

In accordance with strict requirements of portability, cheapness, and modularity, an innovative assistive device for hand disabilities has been developed and validated. This robotic orthosis is designed to be a low-cost, portable hand exoskeleton to assist people with physical disabilities in their everyday lives. Referring to hand opening disabilities, the authors have developed a methodology which, by starting from the geometrical characteristics of the patient's hand, defines the novel kinematic mechanism that better fits to the finger trajectories. The authors have validated the proposed novel mechanism by carrying out a Hand Exoskeleton System (HES) prototype, based on a single-phalanx mechanism, cable driven. The testing phase of the real prototype with a patient is currently on going.

A free-surface-induced morphological instability is studied in the laminar regime at large Reynolds numbers () and on sub-horizontal walls (). We analytically and numerically develop the stability analysis of an inclined melting–freezing interface bounding a free-surface laminar flow. The complete solution of both the linearized flow field and the heat conservation equations allows the exact derivation of the upper and lower temperature gradients at the interface, as required by the Stefan condition, from which the dispersion relationship is obtained. The eigenstructure is obtained and discussed. Free-surface dynamics appears to be crucial for the triggering of upstream propagating ice ripples, which grow at the liquid–solid interface. The kinematic and the dynamic conditions play a key role in controlling the formation of the free-surface fluctuations; these latter induce a streamline distortion with an increment of the wall-normal velocities and a destabilizing phase shift in the net heat transfer to the interface. Three-dimensional effects appear to be crucial at high Reynolds numbers. The role of inertia forces, vorticity, and thermal boundary conditions are also discussed.

This paper presents an experimental study devoted to investigating the effects of permeability on wall turbulence. Velocity measurements were performed by means of laser Doppler anemometry in open channel flows over walls characterized by a wide range of permeability. Previous studies proposed that the von Kármán coefficient associated with mean velocity profiles over permeable walls is significantly lower than the standard values reported for flows over smooth and rough walls. Furthermore, it was observed that turbulent flows over permeable walls do not fully respect the widely accepted paradigm of outer-layer similarity. Our data suggest that both anomalies can be explained as an effect of poor inner–outer scale separation if the depth of shear penetration within the permeable wall is considered as the representative length scale of the inner layer. We observed that with increasing permeability, the near-wall structure progressively evolves towards a more organized state until it reaches the condition of a perturbed mixing layer where the shear instability of the inflectional mean velocity profile dictates the scale of the dominant eddies. In our experiments such shear instability eddies were detected only over the wall with the highest permeability. In contrast attached eddies were present over all the other wall conditions. On the basis of these findings, we argue that the near-wall structure of turbulent flows over permeable walls is regulated by a competing mechanism between attached and shear instability eddies. We also argue that the ratio between the shear penetration depth and the boundary layer thickness quantifies the ratio between such eddy scales and, therefore, can be used as a diagnostic parameter to assess which eddy structure dominates the near-wall region for different wall permeability and flow conditions.