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Our aim in this paper is to establish a generalization of Sobolev’s inequality for Riesz potentials
in Musielak–Orlicz–Morrey spaces
. As a corollary we obtain Sobolev’s inequality for double phase functionals with variable exponents.
Various tools for participatory design approach have been developed to support users to engage design process. Doll scenario is proposed as a generative tool for letting participants make and enact scenarios. However, suitable context to practice doll scenario is unclear in comparison with other tools using scenario. Therefore, our overall objective is to increase understanding of characteristics of making scenario in two different ways of expression; with doll and storyboard. We developed a doll scenario method, doll staging. The tool was evaluated in comparison to storyboard at a workshop which is a part of a new product development project in a corporate. The workshop was evaluated by semi-structured interviews with the participants and observations of the workshop and design outcome. The result suggests that doll staging allows participants to think from users’ perspective in developing new idea. These findings provides new direction to choose scenario based design tools according to objective or context of design project. We also discuss potentials and research directions to use tools for developing scenario in corporate contexts.
Our aim in this paper is to deal with integrability of maximal functions for Herz–Morrey spaces on the unit ball with variable exponent
and for double phase functionals
is nonnegative, bounded and Hölder continuous of order
. We also establish Sobolev type inequality for Riesz potentials on the unit ball.
Our aim in this paper is to establish a generalization of Sobolev’s inequality for Riesz potentials
over bounded non-doubling metric measure spaces. As a corollary we obtain Sobolev’s inequality for double phase functionals with variable exponents.
Maternal gut microbiota is thought to be one of the important factors in the developmental origins of health and disease (DOHaD) concept, but the effects of maternal gut microbiota on foetal growth are not well known. In this study, the association between maternal gut microbiota and foetal growth was investigated. Maternal and newborn information, as well as stool samples at the third trimester of pregnancy, were obtained from 51 mother–newborn pairs from the Chiba study of Mother and Child Health (C-MACH). Gut microbiota was analysed by 16S rRNA sequencing of stool samples and short-chain fatty acids (SCFAs) in stool were analysed by gas chromatography-tandem mass spectrometry. After adjustment for covariates, it was found that maternal gut microbial diversity had a positive association with head circumference in newborn males (Chao 1: adjusted r = 0.515, p = 0.029). Genus Parabacteroides and genus Eggerthella showed negative associations with newborn head circumference and weight, respectively in males (genus Parabacteroides: adjusted r = −0.598, p = 0.009, genus Eggerthella: adjusted r = −0.481, p = 0.043). On the other hand, genus Streptococcus showed a negative association with newborn height in females (adjusted r = −0.413, p = 0.040). In addition, hexanoate was involved in the association between maternal gut microbiota and newborn anthropometrics in the univariate analysis, but not in the multivariate analysis. These data suggest that maternal gut microbiota has sex-specific effects on foetal growth. Maternal gut microbiota is an important factor for optimal intrauterine growth.
Diets enriched with advanced glycation end products (AGE) have recently been related to muscle dysfunction processes. However, it remains unclear whether long-term exposure to an AGE-enriched diet impacts physiological characteristics of skeletal muscles. Therefore, we explored the differences in skeletal muscle mass, contractile function and molecular responses between mice receiving a diet high in AGE (H-AGE) and low in AGE (L-AGE) for 16 weeks. There were no significant differences between L-AGE and H-AGE mice with regard to body weight, food intake or epididymal fat pad weight. However, extensor digitorum longus (EDL) and plantaris (PLA) muscle weights in H-AGE mice were lower compared with L-AGE mice. Higher levels of Nε-(carboxymethyl)-l-lysine, a marker for AGE, in EDL muscles of H-AGE mice were observed compared with L-AGE mice. H-AGE mice showed lower muscle strength and endurance in vivo and lower muscle force production of PLA muscle in vitro. mRNA expression levels of myogenic factors including myogenic factor 5 and myogenic differentiation in EDL muscle were lower in H-AGE mice compared with L-AGE mice. The phosphorylation status of 70-kDa ribosomal protein S6 kinase Thr389, an indicator of protein synthesis signalling, was lower in EDL muscle of H-AGE mice than that of L-AGE mice. These findings suggest that long-term exposure to an AGE-enriched diet impairs skeletal muscle growth and muscle contractile function, and that these muscle dysfunctions may be attributed to the inhibition of myogenic potential and protein synthesis.
For the improvement of oxidation resistance of Nb-based alloys, PdAl-B2 is expected as Al reservoir for Al2O3 surface layer because it is in equilibrium with Nbss (bcc) phase. However, PdAl forms cracks during casting caused by B2 -> β’ transformation. To suppress B2 -> β’ transformation, Rh, Ru and Ir were chosen as additive elements. It is found that bcc / B2 two-phase field in Nb-Pd-Ir-Al system is limited to be small fraction of Ir, while (Pd,Rh)Al-B2 is in equilibrium with bcc solid solution in a wide composition range and addition of Rh prevents occurrence of B2 -> β’ transformation. Composition range of (Pd,Ru)Al-B2 in equilibrium with bcc phase is wider than (Pd,Ir)Al-B2 but narrower than (Pd,Rh)Al-B2. Rh and Ru addition are also beneficial for improving eutectic temperature of Nb-bcc / B2 aluminide two-phase alloys.
Practical use of Resistive Random Access Memory (ReRAM) depends on thorough understanding of the resistive switching (RS) mechanism in polycrystalline metal oxide films. Based on experimental and theoretical results of NiO based ReRAM, we have proposed a grain surface tiling model, in which grain surfaces (i.e. grain boundaries) are composed by insulating and conductive micro surface structures. This paper reports the adequacy of our model to the NiO based ReRAM and universality of surface electronic properties in metal oxides of NiO, CoO and MgO. Experimental results of RS operating modes suggest that the resistance changes in the grain boundaries, supporting our model. First-principles calculation results suggest that our model can be adopted to other metal oxide materials and the RS from a low resistance to a high resistance can be caused at 1000 K, which agrees with previous experimental reports.
Poly-Euler numbers are introduced as a generalization of the Euler numbers in a manner similar to the introduction of the poly-Bernoulli numbers. In this paper, some number-theoretic properties of poly-Euler numbers, for example, explicit formulas, a Clausen–von Staudt type formula, congruence relations and duality formulas, are given together with their combinatorial properties.
In this paper the Very High Energy (VHE) gamma-ray astronomy program at the University of Adelaide is described. VHE gamma rays with energies above ~5 × 1011eV are observed using the atmospheric Cerenkov technique. Results from the first three years observations at Woomera and the current upgrading of the telecope are described. The CANGAROO project, a collaboration between the University of Adelaide and a number of Japanese institutions, is also introduced.
For practical use of Resistive Random Access Memory (ReRAM), understanding resistive switching mechanism in transition metal oxides (TMO) is important. Some papers predict its mechanism by using first principles calculation; for example, TMO become conductive by introducing oxygen vacancy in bulk single crystalline TMO. However, most of ReRAM samples have polycrystalline structures. In this paper, we introduced a periodic slab model to depict grain boundary and calculated the surface energy and density of states for surfaces of NiO with various orientations using first-principles calculation to consider the effect of grain boundaries for resistive switching mechanisms of ReRAM. As a results, vacancies can be formed on the side surface of grain more easily than in grain. Moreover, we showed that surface conductivity depends on surface orientation of NiO and the orientation of side surface of grain can change easily by introduction of vacancies, which is the switching mechanism of NiO-ReRAM
We will characterize the boundedness and compactness of weighted composition operators on the closed subalgebra H∞ ∩
o between the disk algebra and the space of bounded analytic functions on the open unit disk.
This study examined whether the occurrence of late neck metastasis in early tongue squamous cell carcinoma can be predicted by evaluating HMGB1 (high mobility group box 1) expression in the primary lesion.
A case–control study was conducted. The cases comprised 10 patients with late neck metastasis. The controls consisted of 16 patients without recurrence. All were examined immunohistochemically for HMGB1 protein expression. The odds ratio for late neck metastasis in relation to HMGB1 was estimated.
Results for HMGB1 were dichotomised into positive staining scores (score, 5–7) and negative scores (0–4). Six cases (60 per cent) and four controls (25 per cent) were HMGB1-positive. Although no significant result was seen, compared with HMGB1-negative patients the odds ratio for late neck metastasis in HMGB1-positive patients was 3.8 (95 per cent confidence interval, 0.6–26.5) after adjusting for other factors.
In the present study, immunohistochemical study of HMGB1 in early tongue squamous cell carcinoma did not appear to be very useful for predicting occult neck metastasis. Further study is necessary to clarify the relationship between HMGB1 expression and late neck metastasis in early tongue squamous cell carcinoma.
We propose a wireless power distribution system (WPDS) operating at 2.45 GHz CW in buildings instead of wired power distribution in order to reduce the initial cost of the building. Required technologies for the WPDS are (a) low-cost and low-loss deck plate waveguide, (b) variable microwave power distributor for the waveguide, and (c) high-power (>100 W) rectifier at the outlet. We developed and tested the deck plate waveguide, power distributor, and high-power rectenna consisting of 256 Si Schottky barrier diodes and newly developed GaN diodes. Finally, a test WPDS was built and microwave power transmission experiments were conducted. The total efficiency of the test WPDS was estimated to be 52%.
We confirmed a specific detection of immunoglobulin E(IgE) by using an aptamer immobilized reduced graphene oxide(rGo) field effect transistor(FET). A detection limit and dynamic range were estimated 8.1 ng/ml and 10000 respectively. These characteristics are comparable with current fluorescent markers. Although a mobility of rGo FET was around 5 cm2/V.sec, and this is two to three orders lower than mechanically exfoliated pristine graphene FET, a sensitivity of it was only one order lower than using pristine graphene.
In this paper, preamble design for estimation and compensation of channel distortion parameters (or channel impairments) in orthogonal frequency-division multiplexing (OFDM) transmission over peak-limited channels is studied. Specifically, the designed preamble considers the estimation of frequency selective channels, carrier frequency offset (CFO), in-phase/quadrature-phase (I/Q) imbalance together with the minimization of peak-to-average power ratio (PAPR) of the transmitted signals. In the proposed design, we employ adaptive Markov chain Monte Carlo (AMCMC) techniques to select preamble sequence that minimizes the channel estimate mean-squared error while suppressing the effect of the I/Q mismatch. AMCMC algorithm is also deployed to select phase information to the designed preamble in order to minimize the PAPR of the oversampled preamble signals in time domain. To estimate CFO, maximum likelihood-based scheme that utilizes two successive OFDM preambles is employed, and the CFO is estimated by considering phase rotation between two consecutive received OFDM preambles. Numerical simulations are provided to verify the efficacy of the proposed design.