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In this study, we want to evaluate the efficacy of a preventive weight management training. We hypothesize that this training will reduce weight gain, pathological metabolic parameters and will increase drug compliance and subjective well-being.
69 schizophrenic patients were included in this study, in all patients olanzapine was newly initiated. They were randomly assigned to verum and control group. Patients in the verum group attended the training every second week for 24 weeks. Physical and chemical parameters where measured regularly, and also eating behaviour, physical activity, quality of life, mental state and psychosocial adaptation.
28 patients dropped out during the first 4 weeks of intervention. The data of the remaining 41 patients (verum group N=21, control group N=20) was analysed. During the intervention there was no significant difference between the groups regarding weight-gain. Both groups gained weight slightly (verum group 3.02±4.06kg, control group 2.80±4.84kg). Concerning triglycerides we found an interaction effect of time and group (F(1)=6.697, p=.025), the same was found on the second scale of the questionnaire for eating behaviour (FEV), which measures to what degree eating behaviour is disturbed (F(1)=8,381, p=.013) and on the social functioning scale of the SF-36 (F(2,38)=3,34, p=.032). Regarding glucose tolerance challenge, there was a significant group effect at the first time of measure after intake of the glucose-dilution (F(1)=9.15, p=.016). Our results do not support the hypothesis that the intervention has the desired effects on body weight, but it influenced positively other metabolic parameters, eating behaviour and social functioning.
It is well examined that hypothyroidism leads to cognitive losses and depressive moods. A well regulated thyroid metabolic status lowers those dysfunctions. After thyroid cancer and successful hormone replacement therapy cognitive and affective capacities can be re-established.
Do female patients' results in cognitive and affective testing in hypothyroidism after thyroid cancer differ from the same patients' results in euthyroid?
We assume the hypothesis that there is an improvement in cognitive performance and the depressive mood in euthyroidism compared with earlier hypothyroidism.
In this study during 20 months N = 24 healthy female patients' hypothyroid metabolic statuses after thyroid cancer and thyreoidectomy were examined as an inpatient and within at least six months later as an outpatient in euthyroidism. At both examination dates the patients filled in the Beck Depression Inventory (BDI) and a psychometric test battery (Rey-Osterrieth Complex Figure Test, D2-Test).
A Wilcoxon Signed-Rank Test indicate significant differences between hypothyroidism and euthyroid in favour of euthyroid in the BDI (M = z = – 3.56, p < .000), Rey-Osterrieth Complex Figures Test (cognitive reproduction, z = -4.20, p< .001) and the D2-Test (z = – 2.56, p = .011).
Our findings suggest that there is a relation between the hypothyroidism, depressive mood and fields of cognition (concentration and visual memory). It implies that a hormone replacement therapy should be initiated as quickly as possible for patients with hypothyroidism to re-establish their quality of life, performance and treatment compliance.
This book brings together cutting-edge scholarship from the United States and Europe to address political as well as cultural responses to both the arms race of the 1980s and the ascent of nuclear energy as a second, controversial dimension of the nuclear age. Diverse in its topics and disciplinary approaches, Nuclear Threats, Nuclear Fear and the Cold War of the 1980s makes a fundamental contribution to the emerging historiography of the 1980s as a whole. As of now, the era's nuclear tensions have been addressed by scholars mostly from the standpoint of security studies, focused on the geo-strategic deliberations of political elites and at the level of state policy. Yet nuclear anxieties, as the essays in this volume document, were so pervasive that they profoundly shaped the era's culture, its habits of mind, and its politics, far beyond the domain of policy.