Abbreviated Neutron Activation Analysis (NAA) was carried out on a sample of obsidian artifacts from the Terminal Formative to early Late Classic period site of Palo Errado, located in the southern Gulf lowlands of Veracruz, Mexico. Our understanding of Classic period obsidian economies in the southern Gulf lowlands has been largely informed by studies of the political economies of the highland Mexican cities of Teotihuacan and Cantona, which appear to have controlled the Pachuca and Otumba, and Zaragoza-Oyameles obsidian sources, respectively. However, the NAA results from Palo Errado indicate that while the local obsidian economy was dominated by prismatic blade technology utilizing Zaragoza-Oyameles obsidian, five additional highland Mexican sources were used during the Early Classic period. The presence of Ucareo and the use of Otumba in core-blade reduction, for instance, set Palo Errado apart from contemporary sites in the southern Gulf lowlands. Temporal variation in quantity of supplemental obsidian sources and their use in different reduction technologies suggest that consumers at Palo Errado had access to abundant Zaragoza-Oyameles obsidian of a quality high enough to facilitate the production of fine prismatic blades. At the same time, however, they continued to participate in exchange networks that tied them to other areas of central Mexico, independently from other contemporaneous sites in the southern Gulf lowlands.