To send content items to your account,
please confirm that you agree to abide by our usage policies.
If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account.
Find out more about sending content to .
To send content items to your Kindle, first ensure firstname.lastname@example.org
is added to your Approved Personal Document E-mail List under your Personal Document Settings
on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part
of your Kindle email address below.
Find out more about sending to your Kindle.
Note you can select to send to either the @free.kindle.com or @kindle.com variations.
‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi.
‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.
In Daily Life of the Aztecs, Frances Berdan and Michael Smith offer a view into the lives of real people, doing very human things, in the unique cultural world of Aztec central Mexico. The first section focuses on people from an array of social classes - the emperor, a priest, a feather worker, a merchant, a farmer, and a slave – who interacted in the economic, social and religious realms of the Aztec world. In the second section, the authors examine four important life events where the lives of these and others intersected: the birth and naming of a child, market day, a day at court, and a battle. Through the microscopic views of individual types of lives, and interweaving of those lives into the broader Aztec world, Berdan and Smith recreate everyday life in the final years of the Aztec Empire.
Low-resource environments, such as those found in humanitarian crises, pose significant challenges to the provision of proper medical treatment. While the lack of training of health providers to such settings has been well-acknowledged in literature, there has yet to be any scientific evidence for this phenomenon.
This pilot study utilized a randomized crossover experimental design to examine the effects of high- versus low-resource simulated scenarios of a resuscitation of a critically ill obstetric patient on a medical doctors’ performance and inter-personal skills. Ten senior residents (fifth-year post-graduate) of the Maggiore Hospital School of Medicine (Novara, NO, Italy) were included in the study.
Overall performance score for the high-resource setting was 5.2, as opposed to only 2.3 for the low-resource setting. The mean effect size for the overall score was 2.9 (95% CI, 1.7–4.0; P <.001). The results suggest a significant decrease in both technical (medical) and non-technical skills, such as leadership, problem solving, situation awareness, resource utilization, and communication in the low-resource environment setting. The latter finding is of special important since it was yet to be reported.
This pilot study suggests that untrained physicians in low-resource environments may experience a considerable setback not only to their professional performance, but also to their interpersonal skills, when deployed ill-prepared to humanitarian missions. Consequently, this may endanger the health of local populations.
Here we provide an update of the 2013 report on the Nigerian Twin and Sibling Registry (NTSR). The major aim of the NTSR is to understand genetic and environmental influences and their interplay in psychological and mental health development in Nigerian children and adolescents. Africans have the highest twin birth rates among all human populations, and Nigeria is the most populous country in Africa. Due to its combination of large population and high twin birth rates, Nigeria has one of the largest twin populations in the world. In this article, we provide current updates on the NTSR samples recruited, recruitment procedures, zygosity assessment and findings emerging from the NTSR.
This article examines the rate and nature of female representation before the board of trustees for the forfeited estates in Ireland, established by the Act of Resumption in 1700. The legislation was introduced by a discontented English parliament to nullify William III's grants of forfeited Irish land, which he awarded after victory over James II in the War of the Two Kings (1689–91). The act's remit extended well beyond the resumption of freehold land, incorporating real property, judgements, securities, obligations, debts, and goods and chattels forfeited by outlawed Jacobites. It was also retroactive, as all parties with a legitimate title to a property that predated 13 February 1689 were entitled to enter a claim. Using a printed list of 3,140 claims submitted to the trustees, this article analyses the commonality of female claimants, considers their economic, social, and marital status, and identifies the legal or equitable basis for their representation before the trustees. In doing so, it examines prenuptial and familial practices in post-Restoration Ireland, underlines the economic importance of marriage and inheritance as means of conveyance, and suggests that women's and female minors’ successful claims provided a number of Catholic families with a lifeline in the early eighteenth century.
Placental lipids transfer is essential for optimal fetal development, and alterations of these mechanisms could lead to a higher risk of adverse birth outcomes. Low-density lipoprotein receptor (LDLR), LDL receptor-related protein 1 (LRP1), and scavenger receptor class B type 1 (SCARB1) genes are encoding lipoprotein receptors expressed in the placenta where they participate in cholesterol exchange from maternal to fetal circulation. The aim of this study was thus to investigate the association between maternal lipid changes occurring in pregnancy, placental DNA methylation (DNAm) variations at LDLR, LRP1, and SCARB1 gene loci, and newborn’s anthropometric profile at birth. Sixty-nine normoglycemic women were followed from the first trimester of pregnancy until delivery. Placental DNAm was quantified at 43 Cytosine-phosphate-Guanines (CpGs) at LDLR, LRP1, and SCARB1 gene loci using pyrosequencing: 4 CpGs were retained for further analysis. Maternal clinical data were collected at each trimester of pregnancy. Newborns’ data were collected from medical records. Statistical models included minimally newborn sex and gestational and maternal age. Maternal total cholesterol changes during pregnancy (ΔT3-T1) were correlated with DNAm variations at LDLR (r = −0.32, p = 0.01) and LRP1 (r = 0.34, p = 0.007). DNAm at these loci was also correlated with newborns’ cord blood triglyceride and leptin levels. Mediation analysis supports a causal relationship between maternal cholesterol changes, DNAm levels at LRP1 locus, and cord blood leptin concentration (pmediation = 0.02). These results suggest that LRP1 DNAm link maternal blood cholesterol changes in pregnancy and offspring adiposity at birth, which provide support for a better follow-up of blood lipids in pregnancy.
Activists throughout Western Europe joined Southern actors in demanding a reform of global trade during the 1960s. This forum focuses on the subsequent trajectories of fair trade activism: the initiatives which aimed to achieve equitable economic relations between the South and the North. The evolution of this movement is situated within larger debates about social movements since the 1960s. The forum demonstrates the importance of a transnational perspective, particularly the impact of the global South and European integration. It highlights fair trade's broad constituency and the contested development of its goals and repertoire. The movement's trajectories challenge us to reassess how activists attempted to shape a post-colonial world in which consumption had become a predominant fact of life. Regarding this strand of activism as part of crucial post-war developments provides a fresh perspective on the history of transnational civic activism.
This article discusses some of the ways in which ideas about the city influenced the thinking of British Christians from 1840 to the early twentieth century. First, it explores nonconformist conceptions of the city, suggesting that, although the urban environment offered favourable circumstances for nonconformist growth, a desire to return to, or incorporate elements of, rural life was rarely far away. It explores why, when the garden city movement began, it found such fertile soil among Christian thinkers. Secondly, it considers some of the biblical paradigms that shaped late Victorian thinking about the city. Preachers and writers moved seamlessly from their well-stocked religious imaginations to contemplating the practicalities of the city, and back again. It is argued that the Christian evocation of medieval cities, biblical cities and garden cities shaped in important ways the conceptualizations of the urban world.
Retrospectively recalled adverse childhood experiences (ACEs) are associated with adult mood problems, but evidence from prospective population cohorts is limited. The aims of this study were to test links between prospectively ascertained ACEs and adult mood problems up to age 50, to examine the role of child mental health in accounting for observed associations, and to test gender differences in associations.
The National Child Development Study is a UK population cohort of children born in 1958. ACEs were defined using parent or teacher reports of family adversity (parental separation, child taken into care, parental neglect, family mental health service use, alcoholism and criminality) at ages 7–16. Children with no known (n = 9168), single (n = 2488) and multiple (n = 897) ACEs were identified in childhood. Adult mood problems were assessed using the Malaise inventory at ages 23, 33, 42 and 50 years. Associations were examined separately for males and females.
Experiencing single or multiple ACEs was associated with increased rates of adult mood problems after adjustment for childhood psychopathology and confounders at birth [2+ v. 0 ACEs – men: age 23: odds ratio (OR) 2.36 (95% confidence interval (CI) 1.7–3.3); age 33: OR 2.40 (1.7–3.4); age 42: OR 1.85 (1.4–2.4); age 50: OR 2.63 (2.0–3.5); women: age 23: OR 2.00 (95% CI 1.5–2.6); age 33: OR 1.81 (1.3–2.5); age 42: OR 1.59 (1.2–2.1); age 50: OR 1.32 (1.0–1.7)].
Children exposed to ACEs are at elevated risk for adult mood problems and a priority for early prevention irrespective of the presence of psychopathology in childhood.
This history of Kosova since 1989 can be divided into three periods: the period of Serbian rule and Albanian resistance leading to war in 1998–1999; the nine-year period under the United Nations Interim Mission in Kosovo (UNMIK); and the period since Kosova declared its independence in March 2008. In this chapter I focus on institutional transformations of the three periods, economic issues, and interethnic relations of Kosovar Albanians and Serbs. I also contextualize major events and present initiatives of international mediators such as Kai Eide and Martti Ahtisaari. Kosova is the youngest country in Europe. It suffers from high unemployment, poverty, and corruption, as well as isolation due to the European Union’s continued refusal to accord its citizens visa-free travel with the rest of Europe. At the same time it has a committed diaspora population and was able to pull together at crucial times in its history. I present several of its recent leaders, including Ibrahim Rugova, Shpend Ahmeti, Albin Kurti, and Atifeta Jahjaga.
Like any therapy, acupuncture is effective for some patients, while not helpful for others. Understanding from a patients' perspective what makes one respond or not to acupuncture can help guide further intervention development. This study aimed to identify factors that influence the perception of acupuncture's therapeutic effect among cancer survivors with insomnia.
We conducted post-treatment semi-structured interviews with cancer survivors who were randomized to the acupuncture group in a clinical trial for the treatment of insomnia. Survivors were categorized into Responders and Non-Responders to acupuncture treatment based on the change in the Insomnia Severity Index with a reduction of eight points or greater as the cut-off for the response. An integrated approach to data analysis was utilized by merging an a priori set of codes derived from the key ideas and a set of codes that emerged from the data through a grounded theory approach. Codes were examined for themes and patterns.
Among 28 cancer survivors interviewed, 18 (64%) were classified as Responders. Participants perceived the ability to respond to acupuncture as dependent on treatment that effectively: (1) alleviated co-morbidities contributing to insomnia, (2) supported sleep hygiene practices, and (3) provided a durable therapeutic effect. Acupuncture treatment that did not address one of these themes often detracted from positive treatment outcomes and diminished perceived benefit from acupuncture.
Significance of results
We identified patient-perceived contributors to response to acupuncture, such as co-morbid medical conditions, adequate support for sleep hygiene practices, and temporary therapeutic relief. Addressing these factors may improve the overall effectiveness of acupuncture for insomnia.
Whereas the rhetoric of new media at the turn of the millennium stressed the evolution from ‘seeing’ to ‘being’, artists who were most involved in the early stages of virtual reality have moved from the overoptimistic and perhaps almost hubristic notion of ‘being’ as an existential condition of virtual reality, to a far more realistic, humble and ecologically oriented notion of ‘being-in-common’. This contribution looks at two artists in particular – Char Davies and Gary Warner – and the focus of their current work.
TwinsUK is the largest cohort of community-dwelling adult twins in the UK. The registry comprises over 14,000 volunteer twins (14,838 including mixed, single and triplets); it is predominantly female (82%) and middle-aged (mean age 59). In addition, over 1800 parents and siblings of twins are registered volunteers. During the last 27 years, TwinsUK has collected numerous questionnaire responses, physical/cognitive measures and biological measures on over 8500 subjects. Data were collected alongside four comprehensive phenotyping clinical visits to the Department of Twin Research and Genetic Epidemiology, King’s College London. Such collection methods have resulted in very detailed longitudinal clinical, biochemical, behavioral, dietary and socioeconomic cohort characterization; it provides a multidisciplinary platform for the study of complex disease during the adult life course, including the process of healthy aging. The major strength of TwinsUK is the availability of several ‘omic’ technologies for a range of sample types from participants, which includes genomewide scans of single-nucleotide variants, next-generation sequencing, metabolomic profiles, microbiomics, exome sequencing, epigenetic markers, gene expression arrays, RNA sequencing and telomere length measures. TwinsUK facilitates and actively encourages sharing the ‘TwinsUK’ resource with the scientific community — interested researchers may request data via the TwinsUK website (http://twinsuk.ac.uk/resources-for-researchers/access-our-data/) for their own use or future collaboration with the study team. In addition, further cohort data collection is planned via the Wellcome Open Research gateway (https://wellcomeopenresearch.org/gateways). The current article presents an up-to-date report on the application of technological advances, new study procedures in the cohort and future direction of TwinsUK.
In January of 2010, North Carolina (NC) USA implemented state-wide Trauma Triage Destination Plans (TTDPs) to provide standardized guidelines for Emergency Medical Services (EMS) decision making. No study exists to evaluate whether triage behavior has changed for geriatric trauma patients.
The impact of the NC TTDPs was investigated on EMS triage of geriatric trauma patients meeting physiologic criteria of serious injury, primarily based on whether these patients were transported to a trauma center.
This is a retrospective cohort study of geriatric trauma patients transported by EMS from March 1, 2009 through September 30, 2009 (pre-TTDP) and March 1, 2010 through September 30, 2010 (post-TTDP) meeting the following inclusion criteria: (1) age 50 years or older; (2) transported to a hospital by NC EMS; (3) experienced an injury; and (4) meeting one or more of the NC TTDP’s physiologic criteria for trauma (n = 5,345). Data were obtained from the Prehospital Medical Information System (PreMIS). Data collected included proportions of patients transported to a trauma center categorized by specific physiologic criteria, age category, and distance from a trauma center.
The proportion of patients transported to a trauma center pre-TTDP (24.4% [95% CI 22.7%-26.1%]; n = 604) was similar to the proportion post-TTDP (24.4% [95% CI 22.9%-26.0%]; n = 700). For patients meeting specific physiologic triage criteria, the proportions of patients transported to a trauma center were also similar pre- and post-TTDP: systolic blood pressure <90 mmHg (22.5% versus 23.5%); respiratory rate <10 or >29 (23.2% versus 22.6%); and Glascow Coma Scale (GCS) score <13 (26.0% versus 26.4%). Patients aged 80 years or older were less likely to be transported to a trauma center than younger patients in both the pre- and post-TTDP periods.
State-wide implementation of a TTDP had no discernible effect on the proportion of patients 50 years and older transported to a trauma center. Under-triage remained common and became increasingly prevalent among the oldest adults. Research to understand the uptake of guidelines and protocols into EMS practice is critical to improving care for older adults in the prehospital environment.
Does populism threaten American democracy, and if so, what is the nature of that threat? In dialogue with the comparative literature on populism, this article considers the opportunity structure available to populist parties and candidates in the American political system. I argue that compared to most other democracies, the US system offers much less opportunity for organized populist parties but more opportunity for populist candidacies. Today’s major parties may also be more vulnerable to populist insurgency than at other points in US history because of (1) changes in communications technology, (2) the unpopularity of mainstream parties and party leaders, and (3) representation gaps created by an increasingly racialized party system. Although no democratic system is immune to deterioration, the US constitutional system impedes authoritarian populism, just as it obstructs party power generally. But the vulnerability of the major parties to populist insurgency poses a threat to liberal democratic norms in the United States, just as it does elsewhere.
The new species Psoroma nivale is described from an area of late snow-lie in the Keglo Bay area on the eastern side of Ungava Bay, northern Québec, Canada. It is superficially similar to P. hypnorum but has a dark, brownish black thallus colour without reddish hues, much-branched, proliferating squamules, thick paraphyses, distinct but inconspicuous IKI+ ascus tube structures, and characteristic elongate, bacilliform, often asymmetrical ascospores. The new species is compared with possible related taxa and its systematic position discussed. A key to the species of pannarioid lichens reported from arctic areas of North America is also provided.
Subjectivist permissivism is a prima facie attractive view. That is, it's plausible to think that what's rational for people to believe on the basis of their evidence can vary if they have different frameworks or sets of epistemic standards. In this paper, I introduce an epistemic existentialist form of subjectivist permissivism, which I argue can better address “the arbitrariness objection” to subjectivist permissivism in general. According to the epistemic existentialist, it's not just that what's rational to believe on the basis of evidence can vary according to agents’ frameworks, understood as passive aspects of individuals’ psychologies. Rather, what's rational to believe on the basis of evidence is sensitive to agents’ choices and active commitments (as are frameworks themselves). Here I draw on Chang's work on commitment and voluntarist reasons. The epistemic existentialist maintains that what's rational for us to believe on the basis of evidence is, at least in part, up to us. It can vary not only across individuals but for a single individual, over time, as she makes differing epistemic commitments.
The social cohesion of multiethnic states is today at risk across the globe. African states have been facing that risk since their independence from colonial rule more than half a century ago. As elsewhere in the world, Africa’s histories of division and contest have sown seeds of political, social, and economic instability. However, Africa is not a place; it is a large continent. There are nearly 40 states south of the Sahara. A few are constantly wracked by instability, while the rest of the continent is experiencing considerable economic transformation. Ethnic conflict is not universal in Africa.