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Chapter 4 - Neuropathology of Non-Motor Parkinson’s Disease Symptoms

Published online by Cambridge University Press:  05 March 2022

By
Helmut Heinsen  and
Lea Tenenholz Grinberg
Edited by
Néstor Gálvez-Jiménez ,
Amos D. Korczyn  and
Ramón Lugo-Sanchez
Néstor Gálvez-Jiménez
Affiliation:
Florida International University
Amos D. Korczyn
Affiliation:
Tel-Aviv University
Ramón Lugo-Sanchez
Affiliation:
Cleveland Clinic
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Summary

Lewy body disease, an α-synucleinopathy, is the neuropathological counterpart of idiopathic Parkinson’s disease and one of the most frequent neurodegenerative diseases in humans [1]. Parkinson’s disease features compelling motor symptoms. Parkinson summarized these symptoms under the mixed Greek-Latin term paralysis agitans (shaking palsy) [2], and for decades, these motor symptoms described by Parkinson remained the most studied features of Lewy body disease.

However, autonomic dysfunctions and non-motor symptoms associated with Lewy body disease are frequent and often pre-date the onset of motor diseases [3]. Autonomic dysfunctions comprise constipation, bowel dysfunction, seborrheic face, dysphagia, dysarthria, impotence, urinary frequency, bladder dysfunction, orthostatic hypotension, and increased sweating. Other non-motor symptoms include sleep disorders (REM behavior disorder, vivid dreams, daytime drowsiness, sleep fragmentation cognitive impairment, bradyphrenia, tip-of-the-tongue (word-finding) phenomenon, depression, apathy, anhedonia, fatigue, behavioral and psychiatric problems, sensory symptoms including anosmia, ageusia, pain (shoulder, back), and paresthesias [4].

Type
Chapter
Information
Non-motor Parkinson's Disease , pp. 35 - 45
Publisher: Cambridge University Press
Print publication year: 2022

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