Delivery of the infant at the limits of viability is a complex challenge for the obstetrician. Despite the best efforts of obstetricians to prolong gestation beyond 23–24 weeks, there may be compelling reasons to intervene in an ongoing pregnancy for maternal benefit (for example in severe pre-eclampsia or placental abruption) or delivery may be considered for foetal reasons. However, the majority of deliveries at the limits of viability will be the consequence of spontaneous pre-term labour, leaving the obstetrician with the difficult and time-pressured decisions regarding which, if any, interventions may be of benefit to foetal or maternal outcome. In most European countries, the rate of pre-term birth continues to rise, making such clinical scenarios increasingly common.

Significant advances in the field of regenerative medicine have intensified the search for novel sources of stem cells with potential for therapy. Although embryonic and adult tissues can be used for the isolation of pluripotent stem cells, significant limitations including ethical concerns, complexity of isolation/culture and tumorigenicity have hindered translation of laboratory findings to clinical practice.

Third stage practice, including the timing of cord clamping and its impact on neonatal health, has been comprehensively reviewed previously by Downey and Bewley, and this opinion will focus on the evidence about neonatal transition which has been published since. Many professional organisations and experts recommend at least a 30-second delay before clamping the umbilical cord, especially after preterm births.

The venous system is considered the main capacitor of the human body. Approximately 70% of the total blood volume resides in the venous bed, half of which circulates as venous return whereas the other half functions as reserve volume in the splanchnic veins. These veins are richly innervated and highly compliant, and communicate with the systemic circulation via capillaries (entrance) and portal vein and liver (exit). This constitution allows the venous compartment to balance circulating and stored blood volumes, and thus control cardiac output. Clinical conditions with reduced cardiac output are often associated with hampered venous return, resulting in visceral oedema, ascites or organ dysfunction. Organ dysfunction or failure may also result from (sub)obstructed venous outflow, as is illustrated in renal vein thrombosis or in the Nutcracker syndrome. Recently, the application of Doppler ultrasonography in the study of the maternal venous system illustrated that preeclampsia is another cardiovascular disorder with dysfunctional venous haemodynamics. In this opinion paper, we summarise results from Doppler studies of the maternal venous compartment, illustrating that performing venous haemodynamics function tests is to become a fundamental part of an integrated cardiovascular assessment of women with hypertension in pregnancy, facilitating an individualised diagnostic and therapeutic approach for every woman at risk for gestational hypertensive disease.