P fimbriae and other adhesins enhance intestinal persistence of Escherichia coli in early infancy

I. ADLERBERTH; C. SVANBORG; B. CARLSSON; L. MELLANDER; L.-Å. HANSON; F. JALIL; K. KHALIL; A. E. WOLD

doi:10.1017/S0950268898001137

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Resident and transient Escherichia coli strains were identified in the rectal flora of 22 Pakistani infants followed from birth to 6 months of age. All strains were tested for O-antigen expression, adhesin specificity (P fimbriae, other mannose-resistant adhesins or type 1 fimbriae) and adherence to the colonic cell line HT-29. Resident strains displayed higher mannose- resistant adherence to HT-29 cells, and expressed P fimbriae (P=0·0036) as well as other mannose-resistant adhesins (P=0·012) more often than transient strains. In strains acquired during the first month of life, P fimbriae were 12 times more frequent in resident than in transient strains (P=0·0006). The O-antigen distribution did not differ between resident and transient strains, and none of the resident P-fimbriated strains belonged to previously recognized uropathogenic clones. The results suggest that adhesins mediating adherence to intestinal epithelial cells, especially P fimbriae, enhance the persistence of E. coli in the large intestine of infants.

Crossref Citations

This article has been cited by the following publications. This list is generated based on data provided by Crossref.

Adlerberth, Marina Cerquetti, Isabe, Ingegerd 2000. Mechanisms of Colonisation and Colonisation Resistance of the Digestive Tract Part 1: Bacteria/host Interactions. Microbial Ecology in Health and Disease, Vol. 12, Issue. 2, p. 223.

Herı́as, Veronica M. Robertson, Anna-Karin Midtvedt, Tore and Wold, Agnes E. 2001. Escherichia coli S fimbriae do not contribute to intestinal colonization or translocation in the gnotobiotic rat. Microbial Pathogenesis, Vol. 31, Issue. 2, p. 103.

Wold, A. E. and Adlerberth, I. 2002. Short and Long Term Effects of Breast Feeding on Child Health. Vol. 478, Issue. , p. 77.

Nowrouzian, F.L. Monstein, H.-J. Wold, A.E. and Adlerberth, I. 2005. Effect of human milk on type 1 and P-fimbrial mRNA expression in intestinal Escherichia coli strains. Letters in Applied Microbiology, Vol. 40, Issue. 1, p. 74.

Nowrouzian, Forough L. Adlerberth, Ingegerd and Wold, Agnes E. 2006. Enhanced persistence in the colonic microbiota of Escherichia coli strains belonging to phylogenetic group B2: role of virulence factors and adherence to colonic cells. Microbes and Infection, Vol. 8, Issue. 3, p. 834.

Nowrouzian, Forough L. Friman, Vanda Adlerberth, Ingegerd and Wold, Agnes E. 2007. Reduced Phase Switch Capacity and Functional Adhesin Expression of Type 1-Fimbriated Escherichia coli from Immunoglobulin A-Deficient Individuals . Infection and Immunity, Vol. 75, Issue. 2, p. 932.

Nowrouzian, F.L. Östblom, A.E. Wold, A.E. and Adlerberth, I. 2009. Phylogenetic group B2 Escherichia coli strains from the bowel microbiota of Pakistani infants carry few virulence genes and lack the capacity for long-term persistence. Clinical Microbiology and Infection, Vol. 15, Issue. 5, p. 466.

Wold, Agnes E. and Adlerberth, Ingegerd 2014. Persistent Bacterial Infections. p. 115.

2014. Bacterial Adhesion to Animal Cells and Tissues. p. 177.

Štaudová, Barbora Micenková, Lenka Bosák, Juraj Hrazdilová, Kristýna Slaninková, Eva Vrba, Martin Ševčíková, Alena Kohoutová, Darina Woznicová, Vladana Bureš, Jan and Šmajs, David 2015. Determinants encoding fimbriae type 1 in fecal Escherichia coli are associated with increased frequency of bacteriocinogeny. BMC Microbiology, Vol. 15, Issue. 1,

Micenková, Lenka Bosák, Juraj Štaudová, Barbora Kohoutová, Darina Čejková, Darina Woznicová, Vladana Vrba, Martin Ševčíková, Alena Bureš, Jan and Šmajs, David 2016. Microcin determinants are associated with B2 phylogroup of human fecal Escherichia coli isolates. MicrobiologyOpen, Vol. 5, Issue. 3, p. 490.

Sokurenko, Evgeni Mulvey, Matthew A. Stapleton, Ann E. and Klumpp, David J. 2016. Pathoadaptive Mutations in Uropathogenic Escherichia coli . Microbiology Spectrum, Vol. 4, Issue. 2,

Sokurenko, Evgeni 2016. Urinary Tract Infections. p. 331.

Porse, Andreas Gumpert, Heidi Kubicek-Sutherland, Jessica Z. Karami, Nahid Adlerberth, Ingegerd Wold, Agnes E. Andersson, Dan I. and Sommer, Morten O. A. 2017. Genome Dynamics of Escherichia coli during Antibiotic Treatment: Transfer, Loss, and Persistence of Genetic Elements In situ of the Infant Gut. Frontiers in Cellular and Infection Microbiology, Vol. 7, Issue. ,

Patel, Seema Mathivanan, Nithya and Goyal, Arun 2017. Bacterial adhesins, the pathogenic weapons to trick host defense arsenal. Biomedicine & Pharmacotherapy, Vol. 93, Issue. , p. 763.

Nowrouzian, Forough L. Clermont, Olivier Edin, Mona Östblom, Anna Denamur, Erick Wold, Agnes E. Adlerberth, Ingegerd and Elkins, Christopher A. 2019. Escherichia coli B2 Phylogenetic Subgroups in the Infant Gut Microbiota: Predominance of Uropathogenic Lineages in Swedish Infants and Enteropathogenic Lineages in Pakistani Infants. Applied and Environmental Microbiology, Vol. 85, Issue. 24,

Article contents

P fimbriae and other adhesins enhance intestinal persistence of Escherichia coli in early infancy

Abstract

Save article to Kindle

Save article to Dropbox

Save article to Google Drive

Reply to: Submit a response

Your details

You have entered the maximum number of contributors

Conflicting interests