Hostname: page-component-8448b6f56d-c4f8m Total loading time: 0 Render date: 2024-04-24T14:55:51.582Z Has data issue: false hasContentIssue false
  • English
  • Français

Effect of anti-PMSG on distribution of estrogen receptor alpha and progesterone receptor in mouse ovary, oviduct and uterus

Published online by Cambridge University Press:  02 September 2014

Zi Li Lin ,
He Min Ni ,
Yun Hai Liu ,
Xi Hui Sheng ,
Xiang Shun Cui ,
Nam Hyung Kim  and
Yong Guo
Zi Li Lin
Affiliation:
Department of Animal Sciences, Chungbuk National University, Cheongju, Korea.
He Min Ni
Affiliation:
College of Animal Science and Technology, Beijing University of Agriculture, Beijing, China.
Yun Hai Liu
Affiliation:
College of Animal Science and Technology, Beijing University of Agriculture, Beijing, China.
Xi Hui Sheng
Affiliation:
College of Animal Science and Technology, Beijing University of Agriculture, Beijing, China.
Xiang Shun Cui
Affiliation:
Department of Animal Sciences, Chungbuk National University, Cheongju, Korea.
Nam Hyung Kim
Affiliation:
Department of Animal Sciences, Chungbuk National University, Cheongju, Korea.
Yong Guo*
Affiliation:
College of Animal Science and Technology, Beijing University of Agriculture, Beijing, China.
*
All correspondence to: Yong Guo. College of Animal Science and Technology, Beijing University of Agriculture, Beijing, China. Tel: +86 10 80799133. Fax: +86 10 80799468. e-mail: y63guo@126.com
Get access Rights & Permissions [Opens in a new window]

Summary

It is well established that estrogen and progesterone are critical endogenous hormones that are essential for implantation and pregnancy in females. However, the distribution of estrogen receptor α (ERα) and progesterone receptor (PR) in female reproductive tracts is elusive. Herein, we report that after serial treatments with pregnant mare's serum gonadotrophin (PMSG) with or without anti-PMSG (AP), mice could regulate the distribution of ERα and PR in the murine ovary, oviduct and uterus and the level of estradiol in serum. ERα and PR regulation by PMSG and anti-PMSG was estrous cycle-dependent and critical for promoting the embryo-implantation period. Furthermore, our results suggested that AP-42 h treatment is more effective than the other treatments. In contrast, other treatment groups also affected the distribution of ERα and PR in mouse reproductive tracts. Thus, we found that anti-PMSG has the potential to restore the distribution of ERα and PR, which could effectively reduce the negative impact of residual estrogen caused by the normal superovulation effect of PMSG in mice.

Keywords

Anti-PMSGDistribution of ERα and PRPMSG
Type
Research Article
Information
Zygote , Volume 23 , Issue 5 , October 2015 , pp. 695 - 703
Copyright
Copyright © Cambridge University Press 2014 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Alexiadis, M., Eriksson, N., Jamieson, S., Davis, M., Drummond, AE., Chu, S., Clyne, C.D., Muscat, G.E. & Fuller, P.J. (2011). Nuclear receptor profiling of ovary granulosa cell tumors. Horm. Cancer 2, 157–69.CrossRefGoogle ScholarPubMed
Das, S.K., Wang, X.N., Paria, B.C., Damm, D., Abraham, J.A., Klagsbrun, M., Andrews, G.K. & Dey, S.K. (1994). Heparin-binding EGF-like growth factor gene is induced in the mouse uterus temporally by the blastocyst solely at the site of its apposition: a possible ligand for interaction with blastocyst EGF-receptor in implantation. Development 120, 1071–83.CrossRefGoogle ScholarPubMed
Dehdashti, F., Mortimer, J.E., Trinkaus, K., Naughton, M.J., Ellis, M., Katzenellenbogen, J.A., Welch, M.J. & Siegel, B.A. (2009). PET-based estrogen challenge as a predictive biomarker of response to endocrine therapy in women with estrogen-receptor positive breast cancer. Breast Cancer. Res. Treat, 113, 509–17.CrossRefGoogle ScholarPubMed
Dey, S.K., Lim, H., Das, S.K., Reese, J., Paria, B.C., Daikoku, T. & Wang, H.B. (2004). Molecular cues to implantation. Endocr. Rev. 25, 341–73.CrossRefGoogle ScholarPubMed
Halachmi, S., Marden, E., Martin, G., MacKay, H., Abbondanza, C. & Brown, M. (1994). Estrogen receptor-associated proteins: possible mediators of hormone-induced transcription. Science 264, 1455–8.CrossRefGoogle ScholarPubMed
Lessey, B.A., Palomino, W.A., Apparao, K.B.C., Young, S.L. & Lininger, R.A. (2006). Estrogen receptor-alpha (ER-alpha) and defects in uterine receptivity in women. Reprod. Biol. Endocrinol. 4, 2–9.CrossRefGoogle ScholarPubMed
Lim, H.J. & Wang, H.B. (2010). Uterine disorders and pregnancy complications: insights from mouse models. J. Clin. Invest. 120, 1004–15.CrossRefGoogle ScholarPubMed
Linden, H.M., Stekhova, S.A., Link, J.M., Gralow, J.R., Livingston, R.B. & Ellis, G.K. (2006). Quantitative fluoroestradiol positron emission tomography imaging predicts response to endocrine treatment in breast cancer. J. Clin. Oncol. 24, 2793–9.CrossRefGoogle ScholarPubMed
Linden, H.M., Kurland, B.F., Peterson, L.M., Schubert, E.K., Gralow, J.R. & Specht, J.M. (2011). Fluoroestradiol positron emission tomography reveals differences in pharmaco-dynamics of aromatase inhibitors, tamoxifen, and fulvestrant in patients with metastatic breast cancer. Clin. Cancer Res. 17, 4799–805.CrossRefGoogle Scholar
Ma, W.G., Song, H.S., Das, S.K., Paria, B.C. & Dey, S.K. (2003). Estrogen is a critical determinant that specifies the duration of the window of uterine receptivity for implantation. Proc. Natl. Acad. Sci. USA 100, 2963–8.CrossRefGoogle ScholarPubMed
Miura, C., Higashino, T. & Miura, T. (2007). A progestin and an estrogen regulate early stages of oogenesis in fish. Biol. Reprod. 77, 822–8.CrossRefGoogle Scholar
Naglera, J.J., Cavileera, T.D., Verduccic, J.S., Schultzd, I.R., Hooke, S.E. & Haytonf, W.L. (2012). Estrogen receptor mRNA expression patterns in the liver and ovary of female rainbow trout over a complete reproductive cycle. Gen. Comp. Endocrinol. 178, 556–61.CrossRefGoogle Scholar
Ng, E.H.Y., Lau, E.Y.L., Yeung, W.S.B. & Ho, P.C. (2001). HMG is as good as recombinant human FSH in terms of oocyte and embryo quality: a prospective randomized trial. Hum. Reprod. 16, 319–25.CrossRefGoogle ScholarPubMed
Palstra, A.P., Schnabel, D., Nieveen, M.C. & Spaink, H.P. (2010). Temporal expression of hepatic estrogen receptor 1, vitellogenin1 and vitellogenin2 in European silver eels. Gen. Comp. Endocrinol. 166, 1–11.CrossRefGoogle ScholarPubMed
Simón, C., Velasco, J.G., Valbuena, D., Peinado, J.A., Moreno, C., Remohí, J. & Pellicer, A. (1998). Increasing uterine receptivity by decreasing estradiol levels during the preimplantation period in high responders with the use of a follicle-stimulating hormone step-down regimen. Fertil. Steril. 70, 234–9.CrossRefGoogle ScholarPubMed
Vitt, U.A., Hayashi, M., Klein, C. & Hsueh, A.J.W. (2000). Growth differentiation factor-9 stimulates proliferation but suppresses the follicle-stimulating hormone-induced differentiation of cultured granulosa cells from small antral and preovulatory rat follicles. Biol. Reprod. 62, 370–7.CrossRefGoogle ScholarPubMed
Wang, H.B. & Dey, S.K. (2006). Roadmap to embryo implantation: clues from mouse models. Nat. Rev. Genet. 7, 185–99.CrossRefGoogle ScholarPubMed
Wang, H.B., Guo, Y., Wang, D.Z., Kingsley, P.J., Marnett, L.J., Das, S.K., DuBois, R. & Dey, S.K. (2004). Aberrant cannabinoid signaling impairs oviductal transport of embryos. Nat. Med. 10, 1074–80.CrossRefGoogle ScholarPubMed