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Prepulse inhibition of the startle reflex in schizophrenia remains stable with short-term quetiapine

Published online by Cambridge University Press:  16 April 2020

V. Molina ,
D.E. López ,
R. Villa ,
J. Pérez ,
C. Martín ,
A. Ballesteros ,
A. Cardoso  and
C. Sancho
V. Molina*
Affiliation:
Department of Psychiatry, Hospital Clínico Universitario de Salamanca, Paseo de San Vicente, 58–182, 37007Salamanca, Spain Institute for Neuroscience of Castilla y León, Spain
D.E. López
Affiliation:
Institute for Neuroscience of Castilla y León, Spain
R. Villa
Affiliation:
Department of Psychiatry, Hospital Clínico Universitario de Salamanca, Paseo de San Vicente, 58–182, 37007Salamanca, Spain
J. Pérez
Affiliation:
Department of Psychiatry, Hospital Clínico Universitario de Salamanca, Paseo de San Vicente, 58–182, 37007Salamanca, Spain
C. Martín
Affiliation:
Department of Psychiatry, Hospital Clínico Universitario de Salamanca, Paseo de San Vicente, 58–182, 37007Salamanca, Spain
A. Ballesteros
Affiliation:
Department of Psychiatry, Hospital Clínico Universitario de Salamanca, Paseo de San Vicente, 58–182, 37007Salamanca, Spain
A. Cardoso
Affiliation:
Institute for Neuroscience of Castilla y León, Spain
C. Sancho
Affiliation:
Department of Physiology and Pharmacology, Universidad de Salamanca, Salamanca, Spain
*
*Corresponding author. Fax: +34 923 291448. E-mail address: vmolina@usal.es (V. Molina).
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Abstract

Purpose

To study the short-term effect of treatment with quetiapine on prepulse inhibition (PPI) deficits of the startle reflex in schizophrenia patients.

Subjects and methods

Using PPI, we studied a group of 21 schizophrenia patients and 16 controls. Seventeen of the patients were re-tested with PPI after 21 days of treatment with quetiapine.

Results

At baseline, an almost significant decrease in PPI was found in the patients as compared to the controls. PPI measurements did not change in the patients after 21 days of treatment with quetiapine, despite their clinical improvement.

Conclusion

Our results suggest that short-term quetiapine treatment may not modify PPI measures in schizophrenia patients.

Keywords

QuetiapinePrepulse inhibitionSchizophrenia
Type
Original article
Information
European Psychiatry , Volume 26 , Issue 5 , August 2011 , pp. 271 - 275
Copyright
Copyright © Elsevier Masson SAS 2011

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