Historical analysis can contribute to the study of suicide as a form of human behaviour by providing perspective. Examining suicide in relation to changing social conditions, value systems, institutions and ideologies at different periods and in various societies may suggest ways of looking at suicide in our society. Materials presented here also indicate possibilities for further investigation.

Disordered amine metabolism is frequently suggested as being of aetiological significance in schizophrenia. The present study investigates the effects of loading doses of the cate-cholamine precursor L-tyrosine in this illness. Groups of schizophrenic and control subjects were given loading doses of L-tyrosine after which plasma tyrosine levels and excretion of some tyrosine metabolities were measured. In only one parameter, excretion of free p-hydroxyphenylacetic acid, was any significant difference observed between the groups. The study is discussed in relation to some of the biochemical theories advanced from time to time for schizophrenia.

Four patients with ‘developmental dyscalculia’ are described who were initially identified on the basis of clinical tests, reports of longstanding and severe difficulties in arithmetic, and psychological test results. Descriptive psychological testing indicated (1) that the arithmetical deficits could not be accounted for on the basis of a generally low level of intellectual functioning; (2) that of the four basic arithmetical processes that of multiplication was relatively more deficient; (3) that this relative deficiency in multiplication stemmed from a faulty grasp of basic multiplication tables; that this was a real difficulty, experienced subjectively by the patient, and one that could not be accounted for simply by carelessness; and finally, that the degree of difficulty experienced varied with the multiplication table involved. Two kinds of attempt were made to improve arithmetical functioning. The first involved brief remedial coaching programmes directed at the basic multiplication tables: relatively little success was obtained with this method. The second kind of attempt involved methods of bypassing the necessity for learning multiplication tables: some success was obtained with these methods. The discussion concentrates on some of the features which may provide possibly useful cues for identifying ‘developmental dyscalculia’: these are classified in terms of: (1) pattern of deficit displayed; (2) qualitative features of arithmetical performance; and (3) response to remedial teaching. Some suggestions are made concerning further lines of investigation.

Each of 16 phobic patients was treated by six sessions of flooding and six sessions of desensitization in a balanced crossover design. Clinical and physiological measurements were made before treatment and after the sixth and 12th sessions of treatment. Physiological measures were made of increase in heart rate and in spontaneous fluctuations and maximum change in level of skin conductance during neutral and phobic imagery. Patients estimated subjective anxiety during the imagery. Heart rate, skin conductance, and subjective anxiety ratings all differentiated significantly between phobic and neutral imagery. Increase in autonomic activity during imagery was roughly proportional to the intensity of the imagery in a phobic hierarchy. Autonomic changes during imagery imagined in silence did not produce autonomic changes considerably different from those during imagery stimulated by a running commentary from the therapist. Clinical ratings correlated significantly with measures of skin conductance, so that autonomic measures can be useful indicators of change after treatment. However, heart rate, skin conductance, and subjective anxiety during brief periods of imagery did not usually correlate significantly with one another. This supports the view of emotion as a System of responses linked imperfectly across several Systems.

The 8th revision of the International Classification of Diseases (ICD) favoured classification of mental disorders by a combination of predominant syndrome and predominant aetiology. However, this important principle has been carried through incompletely, to the disadvantage of diagnostic flexibility and innovation. In addition, too much work is required for the retrieval of cases with the same aetiology irerspective of the syndromes they exhibit, or of cases with the same syndrome whether in the setting of a personality disorder, a neurosis, or a psychosis. The present paper suggests certain simplifications by which the principle of combined classification can hopefully be applied to develop a more comprehensive and flexible instrument.

A sample of general practitioner referrals to a Psychiatric teaching centre was investigated by means of standard interviews, first with the practitioners and subsequently with the patients. Hospital treatment and disposal were examined in the light of the doctors' reasons for referral, and of the expectations which they and the patients had held of the hospital service. The findings are related to previous work in this field, and the implications for service planning discussed.

Probands with schizophrenia of good and poor prognosis were selected according to defined criteria. Families were investigated blindly. The families with poor prognosis contained significantly more schizophrenia, neurosis, and overall illness, but less affective disorder than the families with good prognosis.

The scores of 269 depressed patients on the Depressive Category-Type Scale were analysed. The distributions of component and total scores were found to be bimodal, indicating that most depressed patients can be divided into an endogenous group and another characterized by the presence of neurotic features and the absence of endogenous ones. These findings were discussed in relation to those of other investigators. The relationship between the differentiation of syndromes and the classification of patients into corresponding diagnostic groups was considered. Finally, it was suggested that it should be interesting to try to estimate, from published data, the correlation between endogenous and neurotic depression in the general population.

The use of a technique of Declining-dose Drug Desensitization (DDDD) in phobic patients is described. An anti-anxiety drug is used (diazepam), the blood level declining during each treatment session and the starting dose for each treatment session being gradually reduced. Some relevant animal work on state-dependent learaing in the drugged-state is briefly reviewed. Despite the multiplicity of other treatments available this method would appear to have some advantages.

A questionnaire concerned with dependency, mainly in the mother–child relationship, and intended for use in child psychiatry, is described. It was administered to the mothers of 116 randomly selected junior and secondary school children in the general population, stratified into age, sex, social class, and school groupings. Two meaningful dimensions were revealed by principal component factor analyses: one concerned with reliance on mother and the other reflecting sociability. Reliability and validity were found to be satisfactory.