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ECT: there is more than just unilateral or bilateral selection!

Published online by Cambridge University Press:  02 January 2018

Mukesh Kripalani
Affiliation:
Northern Deanery, Tees, Esk and Wear Valleys NHS Foundation Trust, email: drmukesh@doctors.org.uk
Vinod Chaugule
Affiliation:
Esk and Wear Valleys NHS Foundation Trust
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Abstract

Type
The columns
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
Copyright © Royal College of Psychiatrists, 2009

The assumption that all doctors are well informed about the latest arguments regarding the pros and cons of unilateral or bilateral electroconvulsive therapy (ECT) may not be right. We would like to take this opportunity to update readers of current developments that may potentially revolutionise or even significantly modify our thinking about this controversial treatment.

As the author says, the UK ECT review group in 2003 had an important shortcoming of inclusion of all stimulus intensities, leading to a dubious conclusion in favour of the advantages of bilateral ECT. 1 Although we do believe that the uncertainty in evidence exists, the emerging evidence base, particularly in the USA and Australia, may tilt the balance of opinion and attitudes, more in favour of right unilateral (RUL) ECT with the ultra-brief type of pulse width.

Sackeim et al Reference Sackeim, Prudic, Nobler, Fitzsimmons, Lisanby and Payne2 and Loo et al Reference Loo, Sainsbury, Sheehan and Lyndon3 have in 2008 published research indicating that ultra-brief pulse width right unilateral ECT is likely as effective as the conventional one (brief pulse RUL), in addition to being significantly better in terms of cognitive disability. This is an exciting new development as we believe cognitive disability has consistently been underplayed in studies on ECT over the years. Robertson & Pryor Reference Robertson and Pryor4 as well as Mangaoang & Lucey Reference Mangaoang and Lucey5 cite extensive relevant body of research suggesting a lot more cognitive damage and disability, undetected by conventional testing. Additionally, if the patients were to be made aware of a potential modality of treatment with significantly less cognitive disability, they may actually make a more completely informed decision.

Although it is not difficult to adapt current practice to using ultra-brief pulse width RUL ECT by slight modification of the ‘programmes’ settings available on current machines in the UK, this detail is clearly beyond the scope of this letter.

In conclusion, we posit that the need for faster recovery by using bilateral ECT may be more than balanced by the need to deliver the treatment that is less disabling (in terms of cognitive disability) and possibly equally effective.

References

1 The UK ECT Review Group. Electroconvulsive therapy: systematic review and meta-analysis of efficacy and safetly in depressive disorders. Lancet 2003; 361: 799808.Google Scholar
2 Sackeim, HA, Prudic, P, Nobler, MS, Fitzsimmons, L, Lisanby, SH, Payne, N, et al. Effects of pulse width and electrode placement on the efficacy and cognitive effects of electroconvulsive therapy. Brain Stimulat 2008; 1: 7183.Google Scholar
3 Loo, CK, Sainsbury, K, Sheehan, P, Lyndon, B. A comparison of RUL ultrabrief pulse (0.3 ms) ECT and standard RUL ECT. Int J Neuropsychopharmacol 2008; 11: 883–90.Google Scholar
4 Robertson, H, Pryor, R. Memory and cognitive effects of ECT: informing and assessing patients. Advan Psychiatr Treat 2006; 12: 228–37.Google Scholar
5 Mangaoang, MA, Lucey, JV. Cognitive rehabilitation: assessment and treatment of persistent memory impairments following ECT. Advan Psychiatr Treat 2007; 13: 90100.Google Scholar
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