Hostname: page-component-76fb5796d-r6qrq Total loading time: 0 Render date: 2024-04-25T08:41:03.974Z Has data issue: false hasContentIssue false
  • English
  • Français

Outcomes of definitive radiotherapy for early laryngeal cancer in terms of survival and patterns of failure

Published online by Cambridge University Press:  03 December 2019

M Adeel ,
M Faisal ,
A Rashid ,
S Rasheed ,
R Hussain ,
K I Malik ,
M Y Hameed  and
A Jamshed
M Adeel
Affiliation:
Surgical Oncology Department, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan
M Faisal*
Affiliation:
Surgical Oncology Department, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan
A Rashid
Affiliation:
Radiation Oncology Department, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan
S Rasheed
Affiliation:
Radiation Oncology Department, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan
R Hussain
Affiliation:
Surgical Oncology Department, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan
K I Malik
Affiliation:
Surgical Oncology Department, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan
M Y Hameed
Affiliation:
Rhodes College, Memphis, USA
A Jamshed
Affiliation:
Radiation Oncology Department, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan
*
Author for correspondence: Dr Muhammad Faisal, Institute of Head and Neck Disease, Evangelisches Krankenhaus, Hans Sachs Gasse 10-12, Vienna1180, Austria E-mail: maxfas@live.com
Get access Rights & Permissions [Opens in a new window]

Abstract

Background

Early laryngeal cancer treated with definitive radiotherapy or surgery has a high cure rate. This study evaluated the patterns of treatment failure and long-term results of early laryngeal cancers treated with definitive radiotherapy.

Method

From January 2002 to December 2014, a total of 242 patients with early-stage laryngeal cancers were treated with radical radiotherapy.

Results

All patients had squamous cell carcinoma of the larynx (92 per cent male and 8 per cent female). Median follow-up was 4.5 years. The majority of patients were smokers (57.4 per cent). Local failure was seen in 12.5 per cent of stage I patients and 22.8 per cent of stage II patients. The 5-year overall survival and disease specific survival were 84 per cent and 91 per cent, respectively.

Conclusion

In summary, radiotherapy is a suitable treatment modality for patients with early-stage laryngeal cancer, with an overall locoregional control rate of 84 per cent. Patients who fail radiotherapy may still undergo salvage laryngectomy.

Keywords

Laryngeal NeoplasmsHead And Neck Neoplasms
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 133 , Issue 12 , December 2019 , pp. 1087 - 1091
Copyright
Copyright © JLO (1984) Limited, 2019

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Footnotes

Dr M Faisal takes responsibility for the integrity of the content of the paper

References

1Jemal, A, Siegel, R, Ward, E, Murray, T, Xu, J, Thun, MJ.Cancer statistics, 2007. CA Cancer J Clin 2007;57:43–66CrossRefGoogle ScholarPubMed
2Ferlay, J, Bray, F, Pisani, P, Parkin, D.Cancer Incidence, Prevalence and Mortality Worldwide. Lyon: IARCPress, 2001Google Scholar
3Hoffman, HT, Porter, K, Karnell, LH, Cooper, JS, Weber, RS, Langer, CJ et al. Laryngeal cancer in the United States: changes in demographics, patterns of care, and survival. Laryngoscope 2006;116:1–13CrossRefGoogle Scholar
4American Society of Clinical Oncology, Pfister, DG, Laurie, SA, Weinstein, GS, Mendenhall, WM, Adelstein, DJ et al. American Society of Clinical Oncology clinical practice guideline for the use of larynx-preservation strategies in the treatment of laryngeal cancer. J Clin Oncol 2006;24:3693–704CrossRefGoogle Scholar
5Mendenhall, WM, Parsons, JT, Million, RR, Fletcher, GH.T1–T2 squamous cell carcinoma of the glottic larynx treated with radiation therapy: relationship of dose-fractionation factors to local control and complications. Int J Radiat Oncol Biol Phys 1988;15:1267–73CrossRefGoogle ScholarPubMed
6van der Voet, JC, Keus, RB, Hart, AA, Hilgers, FJ, Bartelink, H.The impact of treatment time and smoking on local control and complications in T1 glottic cancer. Int J Radiat Oncol Biol Phys 1998;42:247–55CrossRefGoogle ScholarPubMed
7Slavicek, A.Larynx cancer. Postgraduate medicine 2002;4:900–7Google Scholar
8Franchin, G, Minatel, E, Gobitti, C, Talamini, R, Vaccher, E, Sartor, G et al. Radiotherapy for patients with early-stage glottic carcinoma: univariate and multivariate analyses in a group of consecutive, unselected patients. Cancer 2003;98:765–72CrossRefGoogle Scholar
9Fujita, M, Rudoltz, MS, Canady, DJ, Patel, P, Machtay, M, Pittard, MQ et al. Second malignant neoplasia in patients with T1 glottic cancer treated with radiation. Laryngoscope 1998;108:1853–5CrossRefGoogle ScholarPubMed
10Frata, P, Cellai, E, Magrini, SM, Bonetti, B, Vitali, E, Tonoli, S et al. Radical radiotherapy for early glottic cancer: results in a series of 1087 patients from two Italian radiation oncology centers. II. The case of T2N0 disease. Int J Radiat Oncol Biol Phys 2005;63:1387–94CrossRefGoogle Scholar
11Cellai, E, Frata, P, Magrini, SM, Paiar, F, Barca, R, Fondelli, S et al. Radical radiotherapy for early glottic cancer: results in a series of 1087 patients from two Italian radiation oncology centers. I. The case of T1N0 disease. Int J Radiat Oncol Biol Phys 2005;63:1378–86CrossRefGoogle Scholar
12Khan, MK, Koyfman, SA, Hunter, GK, Reddy, CA, Saxton, JP.Definitive radiotherapy for early (T1-T2) glottic squamous cell carcinoma: a 20 year Cleveland Clinic experience. Radiat Oncol 2012;7:193CrossRefGoogle ScholarPubMed
13Johansen, LV, Grau, C, Overgaard, J.Glottic carcinoma and patterns of failure and salvage treatment after curative radiotherapy in 861 consecutive patients. Radiother Oncol 2002;63:257–67CrossRefGoogle ScholarPubMed
14Rudoltz, MS, Benammar, A, Mohiuddin, M.Prognostic factors for local control and survival in T1 squamous cell carcinoma of the glottis. Int J Radiat Oncol Biol Phys 1993;26:767–72CrossRefGoogle ScholarPubMed
15Hartl, DM, De Mones, E, Hans, S, Janot, F, Brasnu, D.Treatment of early-stage glottic cancer by transoral laser resection. Ann Otol Rhinol Laryngol 2007;116:832–6CrossRefGoogle ScholarPubMed
16Mendenhall, WM, Werning, JW, Hinerman, RW, Amdur, RJ, Villaret, DB.Management of T1–T2 glottic carcinomas. Cancer 2004;100:1786–92CrossRefGoogle ScholarPubMed