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The effect of morphology and oxygen uptake on penicillin production by Aspergillus nidulans in submerged culture

Published online by Cambridge University Press:  01 October 1997

J. MOORE  and
M. E. BUSHELL
J. MOORE
Affiliation:
Microbial Products Laboratory, School of Biological Sciences, University of Surrey, Guildford, Surrey GU2 5XH, U.K.
M. E. BUSHELL
Affiliation:
Microbial Products Laboratory, School of Biological Sciences, University of Surrey, Guildford, Surrey GU2 5XH, U.K.
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Abstract

Penicillin was not detected in Aspergillus nidulans liquid cultures with pelleted morphology (pellets 1–5 mm diam.) but production was observed in cultures with homogeneous filamentous morphologies. Adenylate Energy Charge (AEC) and Oxygen Uptake Rates (OUR) were measured in cultures exhibiting the two morphologies and it was shown that the values of both parameters were lowest in pelleted cultures and highest in cultures with a filamentous morphology. In addition, a third morphological form, ‘micropellets’ with intermediate properties between the other two types was encountered. We propose that oxygen limitation brought about by the mass transfer restrictions of pelleted growth inhibits penicillin production.

Type
Research Article
Information
Mycological Research , Volume 101 , Issue 10 , October 1997 , pp. 1237 - 1241
Copyright
The British Mycological Society 1997

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