Skip to main content Accessibility help
×
Hostname: page-component-8448b6f56d-c47g7 Total loading time: 0 Render date: 2024-04-20T00:57:46.007Z Has data issue: false hasContentIssue false

Chapter 14 - Ankle Biters

How to Use TIVA in Children

Published online by Cambridge University Press:  18 November 2019

Michael G. Irwin
Affiliation:
The University of Hong Kong
Gordon T. C. Wong
Affiliation:
The University of Hong Kong
Shuk Wan Lam
Affiliation:
The University of Hong Kong
Get access

Summary

Indications for TIVA in children are essentially the same as adults with the additional benefit of reducing emergence delirium and possibly cognitive dysfunction.[1,2] Fears that children may develop propofol infusion syndrome during routine anaesthesia have not eventuated.[3]

Type
Chapter
Information
Taking on TIVA
Debunking Myths and Dispelling Misunderstandings
, pp. 111 - 123
Publisher: Cambridge University Press
Print publication year: 2019

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Lerman, J..TIVA, TCI, and pediatrics: where are we and where are we going? Paediatr Anaesth 2010; 20: 273–8.Google Scholar
Chandler, J.R., Myers, D., Mehta, D., et al. Emergence delirium in children: a randomized trial to compare total intravenous anesthesia with propofol and remifentanil to inhalational sevoflurane anesthesia. Paediatr Anaesth 2013; 23: 309–15.CrossRefGoogle ScholarPubMed
Wolf, A.R., Potter, F.. Propofol infusion in children: when does an anesthetic tool become an intensive care liability? Paediatr Anaesth 2004; 14: 435–8.CrossRefGoogle ScholarPubMed
West, G.B., Brown, J.H., Enquist, B.J.. A general model for the origin of allometric scaling laws in biology. Science 1997; 276: 122–6.CrossRefGoogle ScholarPubMed
Anderson, B.J., Holford, N.H.. Mechanism-based concepts of size and maturity in pharmacokinetics. Annu Rev Pharmacol Toxicol 2008; 48: 303–32.CrossRefGoogle ScholarPubMed
Welzing, L., Ebenfeld, S., Dlugay, V., Wiesen, M.H., Roth, B., Mueller, C.. Remifentanil degradation in umbilical cord blood of preterm infants. Anesthesiology 2011; 114: 570–7.CrossRefGoogle ScholarPubMed
Rigby-Jones, A.E., Priston, M.J., Sneyd, J.R., et al. Remifentanil-midazolam sedation for paediatric patients receiving mechanical ventilation after cardiac surgery. Br J Anaesth 2007; 99: 252–61.CrossRefGoogle ScholarPubMed
Friis-Hansen, B.. Body water compartments in children: changes during growth and related changes in body composition. Pediatrics 1961; 28: 169–81.CrossRefGoogle ScholarPubMed
Wong, G.L., Morton, N.S.. Total intravenous anesthesia (TIVA) in pediatric cardiac anesthesia. Pediatr Anesth 2011; 21: 560–6.Google Scholar
Choi, B.M., Lee, H.G., Byon, H.J., et al. Population pharmacokinetic and pharmacodynamic model of propofol externally validated in children. J Pharmacokinet Pharmacodyn 2015; 42: 163–77.CrossRefGoogle ScholarPubMed
Chidambaran, V., Venkatasubramanian, R., Sadhasivam, S., et al. Population pharmacokinetic–pharmacodynamic modeling and dosing simulation of propofol maintenance anesthesia in severely obese adolescents. Paediatr Anaesth 2015; 25: 911–23.CrossRefGoogle ScholarPubMed
Jeleazcov, C., Ihmsen, H., Schmidt, J., et al. Pharmacodynamic modelling of the bispectral index response to propofol-based anaesthesia during general surgery in children. Br J Anaesth 2008; 100: 509–16.Google Scholar
Jones, R.D., Chan, K., Andrew, L.J.. Pharmacokinetics of propofol in children. Br J Anaesth 1990; 65: 661–7.Google Scholar
Eleveld, D.J., Colin, P., Absalom, A.R., Struys, M.. Pharmacokinetic–pharmacodynamic model for propofol for broad application in anaesthesia and sedation. Br J Anaesth 2018; 120: 942–59.CrossRefGoogle ScholarPubMed
Eleveld, D.J., Proost, J.H., Cortinez, L.I., Absalom, A.R., Struys, M.M.. A general purpose pharmacokinetic model for propofol. Anesth Analg 2014; 118: 1221–37.CrossRefGoogle ScholarPubMed
Anderson, B.J.. Pediatric models for adult target-controlled infusion pumps. Paediatr Anaesth 2010; 20: 223–32.CrossRefGoogle ScholarPubMed
Iwakiri, H., Nishihara, N., Nagata, O., Matsukawa, T., Ozaki, M., Sessler, D.I.. Individual effect-site concentrations of propofol are similar at loss of consciousness and at awakening. Anesth Analg 2005; 100: 107–10.CrossRefGoogle ScholarPubMed
McCormack, J., Mehta, D., Peiris, K., et al. The effect of a target controlled infusion of propofol on predictability of recovery from anesthesia in children. Paediatr Anaesth 2010; 20: 5662.Google Scholar
Hill, A.V.. The possible effects of the aggregation of the molecules of haemoglobin on its dissociation curves. J Physiol 1910; 14: ivvii.Google Scholar
Coppens, M.J., Eleveld, D.J., Proost, J.H., et al. An evaluation of using population pharmacokinetic models to estimate pharmacodynamic parameters for propofol and bispectral index in children. Anesthesiology 2011; 115: 8393.Google Scholar
Fuentes, R., Cortinez, I., Ibacache, M., Concha, M., Munoz, H.. Propofol concentration to induce general anesthesia in children aged 3–11 years with the Kataria effect-site model. Paediatr Anaesth 2015; 25: 554–9.Google Scholar
Lerman, J., Heard, C., Steward, D.J.. Neonatal tracheal intubation: an imbroglio unresolved. Paediatr Anaesth 2010; 20: 585–90.Google ScholarPubMed
Rochette, A., Hocquet, A.F., Dadure, C., et al. Avoiding propofol injection pain in children: a prospective, randomized, double-blinded, placebo-controlled study. Br J Anaesth 2008; 101: 390–4.CrossRefGoogle ScholarPubMed
Aun, C.S., Sung, R.Y., O’Meara, M.E., Short, T.G., Oh, T.E.. Cardiovascular effects of i.v. induction in children: comparison between propofol and thiopentone. Br J Anaesth 1993; 70: 647–53.CrossRefGoogle ScholarPubMed
Wodey, E., Chonow, L., Beneux, X., Azzis, O., Bansard, J.Y., Ecoffey, C.. Haemodynamic effects of propofol vs thiopental in infants: an echocardiographic study. Br J Anaesth 1999; 82: 516–20.CrossRefGoogle ScholarPubMed
Short, S.M., Aun, C.S.. Haemodynamic effects of propofol in children. Anaesthesia 1991; 46: 783–5.Google Scholar
Wolf, A., Weir, P., Segar, P., Stone, J., Shield, J.. Impaired fatty acid oxidation in propofol infusion syndrome. Lancet 2001; 357: 606–7.CrossRefGoogle ScholarPubMed
Eleveld, D.J., Proost, J.H., Vereecke, H., et al. An allometric model of remifentanil pharmacokinetics and pharmacodynamics. Anesthesiology 2017; 126: 1005–18.CrossRefGoogle ScholarPubMed
Ross, A.K., Davis, P.J., Dear, G.L., et al. Pharmacokinetics of remifentanil in anesthetized pediatric patients undergoing elective surgery or diagnostic procedures. Anesth Analg 2001; 93: 1393–401.CrossRefGoogle ScholarPubMed
Sam, W.J., Hammer, G.B., Drover, D.R.. Population pharmacokinetics of remifentanil in infants and children undergoing cardiac surgery. BMC Anesthesiology 2009; 9: 5.CrossRefGoogle ScholarPubMed
Michelsen, L.G., Holford, N.H., Lu, W., Hoke, J.F., Hug, C.C., Bailey, J.M.. The pharmacokinetics of remifentanil in patients undergoing coronary artery bypass grafting with cardiopulmonary bypass. Anesth Analg 2001; 93: 1100–5.CrossRefGoogle ScholarPubMed
Davis, P.J., Wilson, A.S., Siewers, R.D., Pigula, F.A., Landsman, I.S.. The effects of cardiopulmonary bypass on remifentanil kinetics in children undergoing atrial septal defect repair. Anesth Analg 1999; 89: 904–8.Google Scholar
Minto, C.F., Schnider, T.W., Egan, T.D., et al. Influence of age and gender on the pharmacokinetics and pharmacodynamics of remifentanil. Anesthesiology 1997; 86: 1023.CrossRefGoogle ScholarPubMed
Standing, J.F., Hammer, G.B., Sam, W.J., Drover, D.R.. Pharmacokinetic–pharmacodynamic modeling of the hypotensive effect of remifentanil in infants undergoing cranioplasty. Paediatr Anaesth 2011; 20: 718.CrossRefGoogle Scholar
Galinkin, J.L., Davis, P.J., McGowan, F.X., et al. A randomized multicenter study of remifentanil compared with halothane in neonates and infants undergoing pyloromyotomy. II. Perioperative breathing patterns in neonates and infants with pyloric stenosis. Anesth Analg 2001; 93: 1387–92.Google Scholar
Yu, E.H., Tran, D.H., Lam, S.W., Irwin, M.G.. Remifentanil tolerance and hyperalgesia: short-term gain, long-term pain? Anaesthesia 2016; 71: 1347–62.CrossRefGoogle ScholarPubMed
Barker, N., Lim, J., Amari, E., Malherbe, S., Ansermino, J.M.. Relationship between age and spontaneous ventilation during intravenous anesthesia in children. Paediatr Anaesth 2007; 17: 948–55.CrossRefGoogle ScholarPubMed
Litman, R.S.. Conscious sedation with remifentanil during painful medical procedures. J Pain Symptom Manage 2000; 19: 468–71.CrossRefGoogle ScholarPubMed
Choong, K., AlFaleh, K., Doucette, J., et al. Remifentanil for endotracheal intubation in neonates: a randomised controlled trial. Arch Dis Child 2010; 95: F804.Google Scholar
Marsh, B., White, M., Morton, N., Kenny, G.N.. Pharmacokinetic model driven infusion of propofol in children. Br J Anaesth 1991; 67: 41–8.Google Scholar
Gepts, E., Camu, F., Cockshott, I.D., Douglas, E.J.. Disposition of propofol administered as constant rate intravenous infusions in humans. Anesth Analg 1987; 66: 1256–63.CrossRefGoogle ScholarPubMed
Kataria, B.K., Ved, S.A., Nicodemus, H.F., et al. The pharmacokinetics of propofol in children using three different data analysis approaches Anesthesiology 1994; 80: 104–22.CrossRefGoogle ScholarPubMed
Absalom, A., Amutike, D., Lal, A., White, M., Kenny, G.N.. Accuracy of the ‘Paedfusor’ in children undergoing cardiac surgery or catheterization. Br J Anaesth 2003; 91: 507–13.CrossRefGoogle ScholarPubMed
Sepulveda, P., Cortinez, L.I., Saez, C., et al. Performance evaluation of paediatric propofol pharmacokinetic models in healthy young children. Br J Anaesth 2011; 107: 593600.CrossRefGoogle ScholarPubMed
Rigouzzo, A., Servin, F., Constant, I.. Pharmacokinetic–pharmacodynamic modeling of propofol in children. Anesthesiology 2010; 113: 343–52.CrossRefGoogle ScholarPubMed
Marsh, D.F., Hodkinson, B.. Remifentanil in paediatric anaesthetic practice. Anaesthesia 2009; 64: 301–8.Google Scholar
Davidson, A.J.. Measuring anesthesia in children using the EEG. Paediatr Anaesth 2006; 16: 374–87.CrossRefGoogle ScholarPubMed
Davidson, A.J., Huang, G.H., Rebmann, C.S., Ellery, C.. Performance of entropy and Bispectral Index as measures of anaesthesia effect in children of different ages. Br J Anaesth 2005; 95: 674–9.CrossRefGoogle ScholarPubMed
Davidson, A.J., Sale, S.M., Wong, C., et al. The electroencephalograph during anesthesia and emergence in infants and children. Paediatr Anaesth 2008; 18: 6070.Google Scholar
Jeleazcov, C., Schmidt, J., Schmitz, B., Becke, K., Albrecht, S.. EEG variables as measures of arousal during propofol anaesthesia for general surgery in children: rational selection and age dependence. Br J Anaesth 2007; 99: 845–54.Google Scholar
Panchatsharam, S., Callaghan, M., Day, R., Sury, M.R.. Measured versus predicted blood propofol concentrations in children during scoliosis surgery. Anesth Analg 2014; 119: 1150–7.CrossRefGoogle ScholarPubMed
Eleveld, D.J., Absalom, A.R.. Does it matter how you get from D (drug dose) to E (clinical effect)? Paediatr Anaesth 2015; 25: 544–5.CrossRefGoogle Scholar
Schuttler, J., Ihmsen, H.. Population pharmacokinetics of propofol: a multicenter study. Anesthesiology 2000; 92: 727–38.CrossRefGoogle ScholarPubMed
Steur, R.J., Perez, R.S., De Lange, J.J.. Dosage scheme for propofol in children under 3 years of age. Paediatr Anaesth 2004; 14: 462–7.CrossRefGoogle ScholarPubMed
Malherbe, S., Whyte, S., Singh, P., Amari, E., King, A., Ansermino, J.M.. Total intravenous anesthesia and spontaneous respiration for airway endoscopy in children: a prospective evaluation. Paediatr Anaesth 2010; 20: 434–8.CrossRefGoogle ScholarPubMed
McFarlan, C.S., Anderson, B.J., Short, T.G.. The use of propofol infusions in paediatric anaesthesia: a practical guide. Paediatr Anaesth 1999; 9: 209–16.CrossRefGoogle ScholarPubMed
Engelhardt, T., McCheyne, A.J., Morton, N., et al. Clinical adaptation of a pharmacokinetic model of Propofol plasma concentrations in children. Paediatr Anaesth 2008; 18: 235–9.Google Scholar
Anderson, B.J., Holford, N.H.. Getting the dose right for obese children. Arch Dis Child 2017; 102: 54–5.CrossRefGoogle ScholarPubMed
Anderson, B.J., Holford, N.H.. What is the best size predictor for dose in the obese child? Paediatr Anaesth 2017; 27: 1176–84.Google Scholar
Cortinez, L.I., Anderson, B.J., Penna, A., et al. Influence of obesity on propofol pharmacokinetics: derivation of a pharmacokinetic model. Br J Anaesth 2010; 105: 448–56.Google Scholar
Janmahasatian, S., Duffull, S.B., Ash, S., Ward, L.C., Byrne, N.M., Green, B.. Quantification of lean bodyweight. Clin Pharmacokinet 2005; 44: 1051–65.Google Scholar
Holford, N.H.G., Anderson, B.J.. Allometric size: The scientific theory and extension to normal fat mass. Eur J Pharm Sci 2017; 109S: S59S64.Google Scholar
Rhodin, M.M., Anderson, B.J., Peters, A.M., et al. Human renal function maturation: a quantitative description using weight and postmenstrual age. Pediatr Nephrol 2009; 24: 6776.CrossRefGoogle ScholarPubMed
Munoz, H.R., Cortinez, L.I., Ibacache, M.E., Altermatt, F.R.. Remifentanil requirements during propofol administration to block the somatic response to skin incision in children and adults. Anesth Analg 2007; 104: 7780.Google ScholarPubMed
Dennhardt, N., Boethig, D., Beck, C., et al. Optimization of initial propofol bolus dose for EEG Narcotrend Index-guided transition from sevoflurane induction to intravenous anesthesia in children. Paediatr Anaesth 2017; 27: 425–32.CrossRefGoogle ScholarPubMed
Roberts, F.L., Dixon, J., Lewis, G.T., Tackley, R.M., Prys Roberts, C.. Induction and maintenance of propofol anaesthesia. A manual infusion scheme. Anaesthesia 1988; 43 Suppl: 1417.CrossRefGoogle ScholarPubMed
Morse, J., Hannam, J.A., Cortinez, L.I., et al. A manual propofol infusion regimen for neonates and infants. Pediatr Anaesth 2019; EPub 21 July. doi 10.1111/pan.13706Google Scholar
Coulter, F.L., Hannam, J.A., Anderson, B.J.. Ketofol dosing simulations for procedural sedation. Pediatr Emerg Care 2014; 30: 621–30Google Scholar
Andolfatto, G., Abu-Laban, R.B., Zed, P.J., et al. Ketamine–propofol combination (ketofol) versus propofol alone for emergency department procedural sedation and analgesia: a randomized double-blind trial. Ann Emerg Med 2012; 59: 504–12.Google Scholar
Hui, T.W., Short, T.G., Hong, W., Suen, T., Gin, T., Plummer, J.. Additive interactions between propofol and ketamine when used for anesthesia induction in female patients. Anesthesiology 1995; 82: 641–8.Google Scholar
Coulter, F.L., Hannam, J.A., Anderson, B.J.. Ketofol simulations for dosing in pediatric anesthesia. Paediatr Anaesth 2014; 24: 806–12.Google Scholar
Dallimore, D., Anderson, B.J., Short, T.G., Herd, D.W.. Ketamine anesthesia in children–exploring infusion regimens. Paediatr Anaesth 2008; 18: 708–14.Google Scholar

Save book to Kindle

To save this book to your Kindle, first ensure coreplatform@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Available formats
×

Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

Available formats
×