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Expression patterns of histone deacetylases in bovine oocytes and early embryos, and the effect of their inhibition on embryo development

  • Hanna Segev (a1), Erdogan Memili (a1) and Neal L. First (a1)

Abstract

Gene expression at the onset of bovine embryogenesis is developmentally regulated and histone deacetylases (HDACs) have been shown to play a key role in the control of gene expression during this period of development in other species. We determined expression pattern(s) of powerful repressors, namely histone deacetylase-1, -2 and -3, that may in part regulate gene expression during bovine oogenesis and early embryogenesis at the mRNA and protein levels. Detected fragments of the hdac genes were sequenced and comparison of the sequences showed very high homologies between DNA and amino acid sequences of bovine HDACs and those of human and mouse. RPD3, a yeast global regulator of transcription, was also detected in bovine oocytes and embryos. Results suggest that HDACs may be operative in regulation of zygotic/embryonic gene expression in cattle.

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Corresponding author

All correspondence to: Erdogan Memili. Current address: Harvard Institute of Human Genetics, Room 441A, Harvard Medical School, 4 Blackfan Circle, Boston MA 02115, USA. Fax: +1 (617) 432 3698. e-mail: memili@hihg.med.harvard. edu

Keywords

Expression patterns of histone deacetylases in bovine oocytes and early embryos, and the effect of their inhibition on embryo development

  • Hanna Segev (a1), Erdogan Memili (a1) and Neal L. First (a1)

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