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Effect of milrinone on the meiosis resumption and cytoplasm maturation of buffalo oocytes

Published online by Cambridge University Press:  11 May 2022

Guihua Bian Open the ORCID record for Guihua Bian [Opens in a new window] ,
Wen Shi ,
Linwei Duan ,
Yungan Zhu ,
Laiba Shafique ,
Qingyou Liu ,
Deshun Shi  and
Wenhua Xiao
Guihua Bian
Affiliation:
Jiangsu Agri-animal Husbandry Vocational College, Taizhou, 225300, China
Wen Shi
Affiliation:
Animal Reproduction Institute, State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources, Guangxi University, Nanning, 530005, China
Linwei Duan
Affiliation:
Animal Reproduction Institute, State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources, Guangxi University, Nanning, 530005, China
Yungan Zhu
Affiliation:
Jiangsu Agri-animal Husbandry Vocational College, Taizhou, 225300, China
Laiba Shafique
Affiliation:
Animal Reproduction Institute, State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources, Guangxi University, Nanning, 530005, China
Qingyou Liu
Affiliation:
Animal Reproduction Institute, State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources, Guangxi University, Nanning, 530005, China
Deshun Shi*
Affiliation:
Animal Reproduction Institute, State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources, Guangxi University, Nanning, 530005, China
Wenhua Xiao*
Affiliation:
Jiangsu Agri-animal Husbandry Vocational College, Taizhou, 225300, China
*
Authors for correspondence: Deshun Shi. Jiangsu Agri-animal Husbandry Vocational College, Taizhou, 225300, China. E-mail: ardsshi@gxu.edu.cn.Wenhua Xiao. Jiangsu Agri-animal Husbandry Vocational College, Taizhou, 225300, China. E-mail: bkxwh2006@126.com
Authors for correspondence: Deshun Shi. Jiangsu Agri-animal Husbandry Vocational College, Taizhou, 225300, China. E-mail: ardsshi@gxu.edu.cn.Wenhua Xiao. Jiangsu Agri-animal Husbandry Vocational College, Taizhou, 225300, China. E-mail: bkxwh2006@126.com
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Summary

Buffalo has many excellent economic traits and it is one of the greatest potential livestock. Compared with cattle, buffalo has poorer reproductivity, it is of great significance to improve the development potential of oocytes. Buffalo oocyte in vitro maturation (IVM) has been widely used in production, but the poor development ability of bovine oocytes IVM limits the development of buffalo reproductivity. Milrinone as a phosphodiesterase inhibitor could affect the maturation of oocytes in goat and mice, but there have been few reported studies in water buffalo. To optimize buffalo oocyte in vitro maturation systems, the effects of phosphodiesterase inhibitor (milrinone) on pre-maturation culture of buffalo oocytes were investigated in this study. Buffalo cumulus–oocyte complexes (COCs) were cultured in medium with different concentrations (0, 12, 25, 50 and 100 mol/l) of milrinone for different times (0, 4, 8, 12, 16, 22 and 24 h). The results showed that the buffalo COCs nuclear maturation process could be inhibited by milrinone (25–100 mol/l) in a dose-dependent manner. The inhibitory effect of milrinone on in vitro maturation of buffalo oocytes did not decrease with the extension of time. This indicated that milrinone can be used as a nuclear maturation inhibitor during the maturation process in buffalo oocytes. In addition, milrinone can inhibit the effect of follicle stimulating hormone (FSH)-induced IVM of buffalo oocytes, but with time FSH partially eliminated the inhibition. Therefore, inhibition of milrinone on the nuclear maturation of buffalo oocytes was reversible, and buffalo oocytes can mature normally after the inhibition is lessened.

Keywords

BuffaloIVFIVMMilrinoneOocyte
Type
Research Article
Information
Zygote , Volume 30 , Issue 4 , August 2022 , pp. 571 - 576
Copyright
© The Author(s), 2022. Published by Cambridge University Press

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Footnotes

*

Equivalent contributor authors.

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