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Use of acetylsalicylic acid as a feed additive in poultry nutrition

  • M. ALAGAWANY (a1), M.R. FARAG (a2), M.E. ABD EL-HACK (a1), K. DHAMA (a3) and J. FOWLER (a4)...


Salicylate plays an important role as a non-steroid, anti-inflammatory drug. In poultry, those used most commonly are sodium salicylate (SS) and acetylsalicylic acid (ASA), due to their immunomodulatory, analgesic, antipyretic, and anti-inflammatory activities. Other effects have been reported such as minimising the effects of heat stress, allostatic load, ascites, leg disorders, reducing respiratory and digestive disorders, as well as enhancing growth performance, feed utilisation, nutrient digestion and absorption, egg production and the quality of meat and eggs. Furthermore, ASA plays a key role in lowering cholesterol and triglycerides in blood, meat and eggs, and improvements in immune functions and antioxidant enzymes have been noted in birds. This paper reviews the different characteristics and beneficial applications of ASA in poultry nutrition for improving immunity, production, and safeguarding health, especially under heat stress conditions.


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ABDEL-FATTAH, S.A. (2006) Physiological and immunological adjustments of dietary ascorbic acid and acetyl salicylic acid in heat stressed Japanese quail. Egyptian Poultry Science 26: 1395-1418.
ABOU EL-SOUD, , SABRIEA, B., EBEID, T.A. and EID, Y. Z. (2006) Physiological and antioxidative effects of dietary acetyl salicylic acid in laying Japanese quail (coturnix japonica) under high ambient temperature. Journal of Poultry Science 43: 255-265.
ADAMS, R. and ROGLER, J.C. (1968) The effects of dietary aspirin and humidity on the performance of light and heavy breed chicks. Poultry Science 47: 1348-1368.
AL-MASHHADANI, E.H., PITAN, M.H. and AHMED, K.H. (1988) Effect of dietary aspirin on performance and deposition of abdominal fat in broilers. International Journal of Poultry Science 23: 18-21.
AL-OBAIDI, F.A. and AL-SHADEEDI, S.M. (2010) Effect of dietary aspirin for reducing ascites and enhancing productive performance of broilers reared in high density. Al-Qadisiya Journal of Veterinary Medicine Science 9: 20-25.
ANWAR, B., KHAN, S.A., ASLAM, A., MAQBOOL, A. and KHAN, K.A. (2004) Effects of ascorbic acid and acetylsalicylic acid supplementation on the performance of broiler chicks exposed to heat stress. Pakistan Veterinary Journal 24: 109-112.
BAERT, K.V. and DE BACKER, P. (2003) Comparative pharmacokinetics of three non-steroidal anti-inflammatory drugs in five bird species. Comparative Biochemistry and Physiology C 134: 25-33.
BALOG, J.M. and HESTER, P.Y. (1991) The effect of dietary acetyl salicylic acid on egg shell quality. Poultry Science 70: 624-630.
BRAKE, J., FERKET, P., GRIMES, J., BALNAVE, D., GORMAN, J. and DIBNER, J.J. (1994) Optimum arginine:lysine ratio changes in hot weather. P. 82-104 in Proc. 21st Annual Carolina Poultry Nutrition Conference, Charlotte, NC. USA.
DARGAN, P.I., WALLACE, C.I. and JONES, A.L. (2002) An evidence-based flowchart to guide the management of acute salicylate (aspirin) overdose. Emergency Medicine Journal 19: 206-209.
DE BOEVER, S., NEIRINCKX, E.A., MEYER, E., DE BAERE, S., BEYAERT, R. and DE BACKER, P. (2010) Pharmacodynamics of tepoxalin, sodium-salicylate and ketoprofen in an intravenous lipopolysaccharide inflammation model in broiler chickens. Journal of Veterinary Pharmacology and Therapeutics 33: 564-572.
DEI, H.K. (2014) Egg production response of laying chickens to feather clipping, cool water and aspirin during hot weather conditions. Tropical Animal Health and Production 46: 1523-1526.
DERAKHSHANFAR, A., KHEIRANDISH, R., ALIDADI, S. and BIDADKOSH, A. (2013) Study of long effects of administration of aspirin (acetylsalicylic acid) on bone in broiler chickens. Comparative Clinical Pathology 22: 1201-1204.
EL-KHOLY, M.S. (2013) Physiological studies on Japanese quail as affected by some nutritional treatments. Ph.D. Thesis, Department of Poultry, Faculty of Agriculture, Zagazig University, Zagazig, Egypt.
GILBERT, A.B., MITCHELL, G.G., DAVIDSON, M.F., LAUGHLIN, K.F. and HUGHES, B.O. (1982) Effect of administering two prostaglandin synthetase inhibitors (indomethacin and aspirin) on egg production in the domestic fowl (Gallus domesticus). Research Veterinary Science 33: 216-220.
GLICK, B. (1963) Influence of acetylsalicylic acid on the body temperature of heat-stressed chickens. Nature 200: 603.
HASSAN, S.M., MADY, M.E., CARTWRIGHT, A.L., SABRI, H.M. and MOBARAK, M.S. (2003) Effect of acetyl salicylic acid in drinking water on reproductive performance of Japanese quail (Coturnix coturnix japonica). Poultry Science 82: 1174-1180.
HOCKING, P.M., ROBERTSON, G.W. and GENTLE, M.J. (2005) Effects of non-steroidal anti-inflammatory drugs on painrelated behaviour in a model of articular pain in the domestic fowl. Research in Veterinary Science 78: 69-75.
MAY, J.D. and MCNAUGHTON, J.L. (1980) Effects of dietary ascorbic acid, aspirin, lysine and thiouracil on thyroid activity. Poultry Science 59: 893-899.
MCDANIEL, C.D. and PARKER, H.M. (2004) The effect of acetylsalicylic acid on heat stress infertility of broiler breeder males. International Journal of Poultry Science 9: 570-577.
MCDANIEL, C.D., BALOG, J.M., FREED, M., ELKIN, R.G., WELLENREITER, R.H., KUCZEK, T. and HESTER, P.Y. (1993a) Response of layer breeder to dietary acetyl salicylic acid. 1. Effects on hen performance and eggshell quality. Poultry Science 72: 1084-1092.
MCDANIEL, C.D., BALOG, J.M., FREED, M., ELKIN, R.G., WELLENREITER, R.H., KUCZEK, T. and HESTER, P.Y. (1993b) Response of layer breeder to dietary acetyl salicylic acid. 3. Effect on fertility and hatchability of embryos exposed to control and alleviated incubation temperatures. Poultry Science 72: 1100-1108.
MCNEAL, W.D., FLETCHER, D.L. and BUHR, R.J. (2003) Effects of stunning and decapitation on broiler activity during bleeding, blood loss, carcass and breast meat quality. Poultry Science 82:163-168.
MOHAMMAD, F.K., MANSOOR, A.S. and AL-ZUBAIDY, M.H.I. (2012) Comparative single intraperitoneal dose pharmacokinetics of aspirin and acetaminophen in chicks. Veterinari Medicina 57: 121-124.
MOHAMMED, A.A. (2010) Effect of acetyl salicylic acid (ASA) in drinking water on productive performance and blood characteristic of layer hens during heat stress. International Journal of Poultry Science 9: 382-385.
NAKAUE, H.S., WEBER, C.W. and REED, B.L. (1967) The influence of acetyl salicylic acid on growth and some respiratory enzymes in broiler chicks. Proceedings of the Society for Experimental Biology and Medicine 125: 663-664.
NASEEM, S., YOUNUS, M., BILAL, A., AAMIR, G., ASIM, A. and AKHTER, S. (2005) Effect of ascorbic acid and acetylsalicylic acid supplementation on performance of broiler chicks exposed to heat stress. International Journal of Poultry Science 4: 900-904.
OLUYEMI, J.A. and ADEBANJO, A. (1979) Measures applied to combat thermal stress in poultry under practical tropical environment. Poultry Science 58: 767-773.
POŹNIAK, B., YUAN, H., YI, J.E., GUO, C.Z., DENG, S.J., ZHU, L., YANG, Y. and S´WITALA, M. (2010) Influence of salicylate administration on weight gain and serum biochemical parameters in broiler chickens. Medycyna Weterynaryjna 66: 675-679.
POŹNIAK, B., GRABOWSKI, T., MOTYKIEWICZ-PERS, K., BOBREK, K., RAK, L. and BOBUSIA, K. (2015) Pharmacokinetics of repeated sodium salicylate administration to laying hens: evidence for time dependent increase in drug elimination from plasma and eggs. PloS One 10: e0123526. doi:10.1371/journal.pone.0123526.
POŹNIAK, B., ŚWITAŁA, M., JAWORSKI, K., OKONIEWSKI, P. and NIEWIŃSKI, P. (2013) Comparative pharmacokinetics of acetylsalicylic acid and sodium salicylate in chickens and turkeys. British Poultry Science 54: 538-544.
POŹNIAK, B., SWITALA, M., BOBREK, K., GRACZYK, S. and DZIMIRA, S. (2012) Adverse effects associated with high-dose acetylsalicylic acid and sodium salicylate treatment in broilers. British Poultry Science 53: 777-783.
REID, B.L., KURNICK, A.A., THOMAS, J.M. and HULETT, B.J. (1964) Effect of acetyl salicylic acid and oxytetracycline on the performance of White Leghorn breeders and broiler chicks. Poultry Science 43: 880-884.
REYNOLDS, E.F. (1982) Aspirin and similar analgesic and anti-inflammatory agents. Martindale: the extra pharmacopoeia (28th ed), pp. 234-82.
RICHARD, L.M. (2007) The 100 most important chemical compounds: a reference guide. ABC-CLIO. p. 10. ISBN 978-0-313-33758-1.
RIDDELL, C. (1975) The development of tibial dyschondroplasia. Avian Diseases 19: 443-462.
ROHLEDER, N. (2008) Preventing acute stress-induced inflammatory disinhibition by aspirin: What does it tell us about the mechanism? Brain, Behavior and Immunity 22: 148-149.
ROUSSAN, D.A., KHWALDEH, G.Y., HADDAD, R.R., SHAHEEN, I.A., SALAMEH, G. and AL RIFAI, R. (2008) Effect of ascorbic acid, acetylsalicylic acid, sodium bicarbonate, and potassium chloride supplementation in water on the performance of broiler chickens exposed to heat stress. Journal of Applied and Poultry Research 17: 141-144.
RUBIO-GARCIA, M.E., RUBIO-LOZANO, M.S., PONCE-ALQUICIRA, E., ROSARIO-CORTES, C., NAVA, G.M. and CASTANEDA-SERRANO, M.P. (2015) Improving appearance and microbiologic quality of broiler carcasses with an allostatic modulator. Poultry Science 94: 1957-1963.
SHARMA, M.L. and BHATTI, J.S. (1998) Mechanical and chemical control of heat stress in growing White Leghorn pullets. Indian Journal of Animal Production and Management 14: 102-105.
STILBORN, H.L. (Jr), HARRIS, G.C., BOTTJE, W.G. and WALDROUP, P.W. (1988) Ascorbic acid and acetyl salicylic acid (Aspirin) in the diet of broilers maintained under heat stress conditions. Poultry Science 67: 1183-1187.
THOMAS, J.M., NAKAUE, H.S. and REID, B.L. (1966) Effect of increasing levels of dietary acetyl salicylic acid on performance and cecal microbial counts of White Leghorn pullets. Poultry Science 45: 1313-1317.
TRAŞ, B., INAL, F., BAŞ, A., ALTUNOK, V.L., ELMAS, M. and YAZAR, E. (2000) Effect of continuous supplementation of ascorbic acid, aspirin, vitamin E and selenium on some haematological parameters and serum superoxide dismutase level in broiler chickens. British Poultry Science 41: 664-666.
TRUONG, A., SAYAGO, M.M., KUTTEH, W.H. and KE, R.W. (2016) Subchorionic hematomas are increased in early pregnancy in women taking low-dose aspirin. Fertility and Sterility 105: 1241-1246.
UHRIKOVA, I., SCHEER, P., HLOZKOVA, J., SUCHY, P. (Jr) and SEPSI, M. (2016) Effects of acetylsalicylic acid on coagulation tests and haptoglobin concentrations in rabbits with permanent transvenous pacing. Veterinarni Medicina 61: 528-532.
VECEREK, V., GRBALOVA, S., VOSLAROVA, E., JANACKOVA, B. and MALENA, M. (2006) Effects of travel distance and the season of the year on death rates of broilers transported to poultry processing plants. Poultry Science 85: 1881-1884.
WANG, X., HUANG, L.L., CHEN, D.M., IHSAN, A. and YUAN, Z.H. (2010) Analytical determination and pharmacokinetics of major metabolites of carbasalate calcium in broilers following oral administration. Journal of Veterinary Pharmacology and Therapeutics 34: 410-416.
WEISSMANN, G. (1991) Aspirin. Science American 264: 84-90.
WHITING, T.L., DRAIN, M.E. and RASALI, D.P. (2007) Warm weather transport of broiler chickens in Manitoba. II. Truck management factors associated with death loss in transit to slaughter. Canadian Veterinary Journal 48: 148-154.
WU, D., ZHANG, M., LU, Y., TANG, S., KEMPER, N., HARTUNG, J. and BAO, E. (2016a) Aspirin-induced heat stress resistance in chicken myocardial cells can be suppressed by BAPTA-AM in vitro. Cell Stress Chaperones 21: 817-827.
WU, D., ZHANG, M., XU, J., SONG, E., LV, Y., TANG, S., ZHANG, X., KEMPER, N., HARTUNG, J. and BAO, E. (2016b) In vitro evaluation of aspirin-induced HspB1 against heat stress damage in chicken myocardial cells. Cell Stress Chaperones 21: 405-413.
WU, D., XU, J., SONG, E., TANG, S., ZHANG, X., KEMPER, N., HARTUNG, J. and BAO, E. (2015) Acetyl salicylic acid protected against heat stress damage in chicken myocardial cells and may associate with induced Hsp27 expression. Cell Stress Chaperones 20: 687-696.
ZHANG, X., QIAN, Z., ZHU, H., TANG, S., WU, D., ZHANG, M., KEMPER, N., HARTUNG, J. and BAO, E. (2016) HSP90 gene expression induced by aspirin is associated with damage remission in a chicken myocardial cell culture exposed to heat stress. British Poultry Science 57:462-73.


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Use of acetylsalicylic acid as a feed additive in poultry nutrition

  • M. ALAGAWANY (a1), M.R. FARAG (a2), M.E. ABD EL-HACK (a1), K. DHAMA (a3) and J. FOWLER (a4)...


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