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Dendritic cell harmonised immunity to poultry pathogens; a review

Published online by Cambridge University Press:  03 July 2017

Z.U. REHMAN ,
S. UMAR ,
C. MENG ,
Z. ULLAH ,
F. RIAZ ,
S.U. REHMAN  and
C. DING
Z.U. REHMAN
Affiliation:
Shanghai Veterinary Research Institute (SHVRI), Chinese Academy of Agricultural Sciences (CAAS), Shanghai, China Faculty of Veterinary and Animal Sciences, PMAS Arid Agriculture University, Rawalpindi, Pakistan
S. UMAR
Affiliation:
Faculty of Veterinary and Animal Sciences, PMAS Arid Agriculture University, Rawalpindi, Pakistan
C. MENG
Affiliation:
Shanghai Veterinary Research Institute (SHVRI), Chinese Academy of Agricultural Sciences (CAAS), Shanghai, China
Z. ULLAH
Affiliation:
Department of Animal Sciences, University of Sargodha, Sargodha, Pakistan
F. RIAZ
Affiliation:
Shanghai Veterinary Research Institute (SHVRI), Chinese Academy of Agricultural Sciences (CAAS), Shanghai, China
S.U. REHMAN
Affiliation:
Faculty of Veterinary and Animal Sciences, PMAS Arid Agriculture University, Rawalpindi, Pakistan
C. DING*
Affiliation:
Shanghai Veterinary Research Institute (SHVRI), Chinese Academy of Agricultural Sciences (CAAS), Shanghai, China
*
Corresponding author: shoveldeen@shvri.ac.cn
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Abstract

Dendritic cells (DCs) are antigen-presenting cells (APCs) with the unique ability to induce both innate immune responses and a highly specific acquired immunity. DCs are crucial to induce immunity, and their maturation and functions are influenced by microbial and environmental stimuli. Chicken DCs are composed of several subtypes including bursal secretory dendritic cells (BSDCs), follicular dendritic cells (FDCs), and thymic dendritic cells (TDCs). DC maturation depends on the nature of the perturbation and permits unique and efficient immune responses for each pathogen. DCs differentially recognise the viruses, bacteria, parasite and fungi and specifically regulate the immune response. Dendritic cells (DCs) are ‘nature's adjuvants’ and, as such represent an essential component of any vaccination strategy. The understanding of DC regulatory mechanisms opens a new horizon for the development of new vaccines and their targeting with the vaccination for elicitation of better immunity levels. The following review summarises the current state of knowledge of DCs and their specific functions during host pathogens interaction.

Keywords

dendritic cellsimmunityvirusbacteriaparasitevaccinespoultry
Type
Reviews
Information
World's Poultry Science Journal , Volume 73 , Issue 3 , September 2017 , pp. 581 - 590
Copyright
Copyright © World's Poultry Science Association 2017 

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