CGA-43089 [α-(cyanomethoximino)-benzacetonitrile] seed treatment was evaluated at three Nebraska locations during 1979 and 1980 for grain sorghum [Sorghum bicolor (L.) Moench] protection from injury by metolachlor [2-chloro-N-(2-ethyl-6-methylphenyl)-N-(2-methoxy-1-methylethyl)acetamide], four other chloroacetanilide herbicides, and three metolachlor + s-triazine combinations. Acetochlor [2-chloro-N-(ethoxymethyl)-6′-ethyl-o-acetotoluidide] caused the most frequent and severest injury to unprotected and protected sorghum. Soilincorporated metolachlor produced more consistent injury than preemergence application to unprotected sorghum, but placement did not affect CGA-43089 protection. Sorghum-stand reduction was the type of injury most frequently encountered, but crop yield was least affected. CGA-43089 always protected the grain sorghum from yield reduction with these herbicides.