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Barnyardgrass is a problem in winter wheat fields in the central Great Plains following harvest. Glyphosate plus 2,4-D efficacy on barnyardgrass with or without atrazine was investigated under various watering events at three sites in west central Nebraska. Two experiments were initiated at each site. One experiment dealt with rainfall and the other rainfall plus irrigation. Main plots in stubble fields infested with barnyardgrass were sprayed with glyphosate plus 2,4-D at 0.4 plus 0.7, 0.5 plus 0.8, and 0.6 plus 1.0 kg ae ha−1 alone and with 2.2 kg ai ha−1 atrazine. Barnyardgrass was under drought stress in unwatered areas in 1991 at two sites, but the 1993 site was waterlogged. Glyphosate plus 2,4-D at 0.6 plus 1.0 kg ha1 controlled 62, 99, and 100% of the barnyardgrass at the three sites 30 DAT. Nevertheless, control was reduced to 48, 88, and 35% when atrazine was combined with glyphosate plus 2,4-D. Poorest control came when plants were under stress from drought or waterlogging and atrazine was included in the spray solution. In subplots barnyardgrass plants in a 0.8 m2 area were watered 6, 3, or 1 d before spraying and 1, 4, 7, or 11 d after spraying. By watering drought-stressed barnyardgrass 6 d before spraying, control generally was similar or better than with later watering dates. Watering 6 d before spraying with glyphosate plus 2,4-D plus atrazine at 0.6 plus 1.0 plus 2.2 kg ha−1 reduced but did not eliminate antagonism from atrazine.