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Suppression of cone-driven responses by rods in the isolated frog retina

Published online by Cambridge University Press:  02 June 2009

Cun-Jian Dong ,
Hao-Hua Qian ,
John S. McReynolds ,
Xiong-Li Yang  and
Yu-Min Liu
Cun-Jian Dong
Affiliation:
Shanghai Institute of Physiology, Chinese Academy of Sciences, Shanghai, China Department of Physiology, The University of Michigan, Ann Arbor
Hao-Hua Qian
Affiliation:
Shanghai Institute of Physiology, Chinese Academy of Sciences, Shanghai, China
John S. McReynolds
Affiliation:
Department of Physiology, The University of Michigan, Ann Arbor
Xiong-Li Yang
Affiliation:
Shanghai Institute of Physiology, Chinese Academy of Sciences, Shanghai, China
Yu-Min Liu
Affiliation:
Shanghai Institute of Physiology, Chinese Academy of Sciences, Shanghai, China
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Abstract

The sensitivity of rod- and cone-driven responses was studied in the isolated frog retina during the period of rapid dark adaptation following a conditioning flash which bleached a negligible amount of visual pigment. Following a conditioning flash, cone-driven b-wave responses were first enhanced and then depressed. The time courses of the enhancement and subsequent depression of cone-drive responses varies greatly with the intensity and wavelength of the conditioning flash, but were identical when the conditioning' flashes were matched for equal excitation of 502 nm rods. These changes in cone-driven response sensitivity were correlated with the desensitization and recovery of rods following the conditioning flash. When signal transmission from rods to second-order cells was interrupted by the addition of L-glutamate, the conditioning flash did not produce the above-described enhancement and subsequent depression of long-wavelength receptor potential responses. The suppression of cone-driven response therefore appears to be due to a synaptically mediated influence from 502 nm rods which is maximal when the rods are in the dark-adapted state, with little or no contribution from 433 nm rods, and no involvement of the pigment epithelium.

Keywords

Isolated retinaRodConeRod-cone interactionFrogGlutamate
Type
Research Articles
Information
Visual Neuroscience , Volume 1 , Issue 4 , July 1988 , pp. 331 - 338
Copyright
Copyright © Cambridge University Press 1988

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References

Alexander, K.R. & Fishman, G.A. (1984). Rod-cone interaction in flicker perimetry. British Journal of Ophthalmology 68, 303–309.CrossRefGoogle ScholarPubMed
Arden, G.B. & Frumkes, T.E. (1986). Stimulation of rods can increase cone flicker ERGs in man. Vision Research 26, 711–721.CrossRefGoogle ScholarPubMed
Attwell, D.A., Werblin, F.S., Wilson, M. & Wu, S.M. (1983). A sign-reversing pathway from rods to double and single cones in the retina of the tiger salamander. Journal of Physiology 336, 313–333.CrossRefGoogle ScholarPubMed
Coletta, N.J. & Adams, A.J. (1984). Rod-cone interactions in flicker detection. Vision Research 24, 1330–1340.CrossRefGoogle ScholarPubMed
Dodt, E. & Jessen, K.H. (1960). Depression of cone sensitivity during dark adaptation. Experientia 16, 205–206.CrossRefGoogle ScholarPubMed
Dong, C.J., Qian, H.H., Liu, Y.M. & Yang, X.L. (1986). An investigation on the suppression of cone by rod in the isolated frog retina. Acta Physiologica Sinica 38, 555–564.Google Scholar
Fatechand, R. (1979). Attenuation of the frog's cone system during rapid dark adaptation. Vision Research 19, 279–286.CrossRefGoogle ScholarPubMed
Frumkes, T.E. & Eysteinsson, T. (1987). Suppressive rod-cone interaction in distal vertebrate retina: intracellular records from Xeno-pus and Necturus. Journal of Neurophysiology 53, 1361–1382.CrossRefGoogle Scholar
Goldberg, S.H., Frumkes, T.E. & Nygaard, R.W. (1983). Inhibitory influence of unstimulated rods in the human retina: evidence provided by examining cone flicker. Science 221, 180–182.CrossRefGoogle ScholarPubMed
Granit, R. (1947). Sensory Mechanisms of the Retina. New York: Oxford University Press.Google Scholar
Hassin, G. & Witkovsky, P. (1983). Intracellular recording from identified photoreceptors and horizontal cells of the Xenopus retina. Vision Research 23, 921–931.CrossRefGoogle ScholarPubMed
Hood, D.C. (1972 a). Suppression of the frog's cone system in the dark. Vision Research 12, 889–907.CrossRefGoogle ScholarPubMed
Hood, D.C. (1972 b). Adaptational changes in the cone system of the isolated frog retina. Vision Research 12, 875–888.CrossRefGoogle ScholarPubMed
Kuznetsova, L.P. (1960). Electrophysiological investigation of the threshold sensitivity of the dark-adapted eye of the frog and the influence on it of red and blue light. Biofizika 5, 404–411.Google Scholar
Kuznetsova, L.P. (1963). Effect of dark adaptation on the sensitivity of single elements of the frog retina to various monochromatic radiations. Biofizika 8, 234–237.Google Scholar
Liebman, P.A. (1972). Microspectrophotometry (MSP) of photoreceptors. In Handbook of Sensory Physiology, VII/I, ed. Dartnall, H.J.A., pp 481–528. Berlin: Springer-Verlag.Google Scholar
Pflug, R. & Nelson, R. (1987). Background enhancement of cone signals in cat horizontal cells. Investigative Ophthalmology and Visual Science (Suppl.) 28, 240.Google Scholar
Qian, H.H., Dong, C.J. & Liu, Y.M. (1986). Preparation of isolated retina of Rana nigromaculata and determination of photosensitivity of rhodopsin in situ. Acta Physiologica Sinica 38, 139–148.Google ScholarPubMed
Sillman, A.J., Ito, H., Tomita, T. (1969). Studies on the mass receptor potential of the isolated frog retina. Vision Research 9, 1435–1442.CrossRefGoogle ScholarPubMed