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Relationships between Müller cells and neurons in a primitive tetrapod, the Australian lungfish

  • Stephen R. Robinson (a1)

Abstract

We recently proposed a model of cytogenesis which assumes that primitive ancestral mammals and premammalian vertebrates had a retinal composition that consisted of about seven neurons per Müller cell, comprising 1–2 cone photoreceptors, 1–2 rod photoreceptors, 2–3 bipolar cells, 1–2 amacrine cells, less than 1 ganglion cell, and less than 1 horizontal cell (Reichenbach & Robinson, 1995). The Australian lungfish (Neoceratodus forsten) closely resembles the lobe-finned ancestors of land vertebrates, and has an extremely plesiomorphic nervous system. The present study, therefore, has examined the relative frequencies of retinal neurons and Müller cells (identified by immunolabelling for glutamine synthetase) in the lungfish retina. It was found that for each Müller cell there is an average of 1.9 cone photoreceptors, 1.7 rod photoreceptors, 3.1 amacrine/bipolar/horizontal cells, and 0.6 ganglion cells; amounting to a ratio of 7.3 neurons per Müller cell. These results support our conjecture that the sequence of cytogenesis in mammals is constrained by a developmental program that predates the evolution of mammals. The study also provides the first detailed morphological descriptions of lungfish Müller cells and their relationship with adjacent neurons. It was found that individual Müller cells in lungfish have a volume (more than 12,000 μm3) that is an order of magnitude higher than in mammals, yet the proportion of total retinal volume occupied by these cells (20%) is very similar.

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Coates, M.I. & Clack, J.A. (1991). Fish-like gills and breathing in the earliest known tetrapod. Nature 352, 234236.
Dreher, Z., Robinson, S.R. & Distier, C. (1992). Müller cells in vascular and avascular retinae: A survey of seven mammals. Journal of Comparative Neurology 323, 5980.
Kemp, A. (1991). Australian Mesozoic and Camozoic lungfish. In Verte brate Palaeontology of Australasia, ed. Vickers-Rich, P., Monaghan, J.M., Baird, R.F. & Rich, T.H., pp. 465496. Melbourne, Australia: Pioneer Design Studio.
Linser, P.J. (1991). Comparative immunocytochemistry of elasmobranch retina Muller cells and horizontal cells. Journal of Experimental Zoology (Suppl.) 5, 8896.
Linser, P.J., Sorrentimg, M. & Moscona, A.A. (1984). Cellular compartmentalization of carbonic anhydrase-C and glutamine synthetase in developing and mature mouse neural retina. Developmental Brain Research 13, 6573.
Linser, P.J., Smith, K. & Angelides, K. (1985). A comparative analysis of glial and neuronal markers in the retina of fish: Variable character of horizontal cells. Journal of Comparative Neurology 237, 264272.
Locket, N.A. (1970). Landolt's club in the retina of the African lungfish. Protopterus aethiopicus. Heckel. Vision Research 10, 299306
Marshall, C.R. (1986). A list of fossil and extant Dipnoans. Journal of Morphology (Suppl.) 1, 1524.
Northcutt, R.G. (1986). Lungfish neural characters and their bearing on Sarcopterygian phylogeny. Journal of Morphology (Suppl.) 1, 277297.
Pow, D.V. (1994). Taurine, amino acid transmitters, and related molecules in the retina of the Australian lungfish Neoceratodus forsteri: A light microscopic immunocytochemical and electron-microscopic study. Cell and Tiissue Research 278, 311326.
Rasmussen, K.-E. (1975). A morphometric study of the Muller cell in rod and cone retinas with and uithout retinal vessels. Experimenial Eve Research 20, 151166.
Reichenbach, A., Hagen, E., Schippei, K. & Eberhardi, W. (1988). Quantitative electron microscopy of rabbit Muller (ghal) cells in dependence on retinal topography. Zeitschrift fur Mikroskopisch-Anatomische Forschung 102, 721755.
Reichenbach, A., Schneider, H., Leibneiz, L., Reichell, P., Schaae, P., & Schumann, R., (1989). The structure of rabbit retinal Muller (ghal) cells is adapted to the surrounding retinal layers. Anatomy and Embryology 180, 7179.
Reichenbach, A. & Robinson, S.R. (1995). Phylogenetic constraints on retinal organisation and development. Progress in Retinal and Eye Research 15, 139171.
Robinson, S.R. (1991). Development of the mammalian retina. In Neuroanatomy of the Visual Pathways and Their Development, ed. Dreher, B. & Robinson, S.R., pp. 69128. UK: Macmillan Press.
Robinson, S.R. (1994). Early vertebrate colour vision. Nature 367, 121.
Robinson, S.R. (1996). A glimpse into the past: Müller cells in a primitive tetrapod. Journal for Brain Research 37, 226.
Robinson, S.R. & Dreher, Z. (1990). Müller cells in adult rabbit retinae: Morphology, distribution and implications for function and development. Journal of Comparative Neurology 292, 178192.
Sassoé Pognetto, M., Panzanelli, P., Atero, C., Fasolo, A. & Cantino, D. (1992). Comparative study of glial fibrillary acidic protein (GFAP)-like immunoreactivity in the retina of some representative vertebrates. European Journal of Histochemistry 36, 467477.
Vaughan, D.K. & Lasater, E.M. (1990). Glial and neuronal markers in bass retinal horizontal and Müller cells. Brain Research 537, 131140.

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Relationships between Müller cells and neurons in a primitive tetrapod, the Australian lungfish

  • Stephen R. Robinson (a1)

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