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Is there an omitted stimulus response in the human cone flicker electroretinogram?

  • J. JASON McANANY (a1) and KENNETH R. ALEXANDER (a1) (a2) (a3)


Omitting a stimulus from a train of repetitive stimuli, by either interrupting or terminating the train, can elicit an electrophysiological response that occurs at the time appropriate for the omitted stimulus. This study investigated whether such an omitted stimulus response (OSR) is present in the flicker electroretinogram (ERG) of the human cone system. ERGs were recorded from 11 visually normal subjects in response to full-field sinusoidal flicker trains presented against a rod-desensitizing adapting field at frequencies ranging from 12.5 to 100 Hz. Recordings were synchronized with the onset of the stimulus trains, and the amplitude and relative delay of any additional ERG responses following the offset of the flicker train were analyzed. At stimulus frequencies below 35 Hz, the number of ERG responses always equaled the number of stimulus cycles. However, over the frequency range of 38.5 to 100 Hz, the ERG contained an extra response following flicker train offset. At stimulus frequencies from 38.5 to 62.5 Hz, there was a constant delay between the peak of the extra ERG response and the time at which the next stimulus would have occurred had the flicker train continued. This constant delay is characteristic of an OSR. In addition, an extra ERG response was apparent at these same stimulus frequencies if the flicker train was interrupted by omitting stimulus cycles from the middle of the train. The pattern of ERG findings is consistent with a recently proposed model of the OSR that attributes the phenomenon to a resonant oscillation in retinal bipolar cells.


Corresponding author

*Address correspondence and reprint requests to: Kenneth R. Alexander, Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, 1855 W. Taylor Street, Chicago, IL 60612. E-mail:


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Alexander, K.R., Raghuram, A. & McAnany, J.J. (2008). Comparison of spectral measures of period doubling in the cone flicker electroretinogram. Documenta Ophthalmologica 117, 197203.
Alexander, K.R., Rajagopalan, A.S., Raghuram, A. & Fishman, G.A. (2006). Activation phase of cone phototransduction and the flicker electroretinogram in retinitis pigmentosa. Vision Research 46, 27732785.
Bullock, T.H., Karamürsel, S., Achimowicz, J.Z., McClune, M.C. & Başar-Eroglu, C. (1994). Dynamic properties of human visual evoked and omitted stimulus potentials. Electroencephalography and Clinical Neurophysiology 91, 4253.
Crevier, D.W. & Meister, M. (1998). Synchronous period-doubling in flicker vision of salamander and man. Journal of Neurophysiology 79, 18691878.
Kondo, M. & Sieving, P.A. (2001). Primate photopic sine-wave flicker ERG: Vector modeling analysis of component origins using glutamate analogs. Investigative Ophthalmology and Visual Science 42, 305312.
Kremers, J. (2003). The assessment of L- and M-cone specific electroretinographical signals in the normal and abnormal human retina. Progress in Retinal and Eye Research 22, 579605.
Krishna, V.R., Alexander, K.R. & Peachey, N.S. (2002). Temporal properties of the mouse cone electroretinogram. Journal of Neurophysiology 87, 4248.
Schwartz, G. & Berry, M.J. (2008). Sophisticated temporal pattern recognition in retinal ganglion cells. Journal of Neurophysiology 99, 17871798.
Schwartz, G., Harris, R., Shrom, D. & Berry, M.J. (2007). Detection and prediction of periodic patterns by the retina. Nature Neuroscience 10, 552554.
Viswanathan, S., Frishman, L.J. & Robson, J.G. (2002). Inner-retinal contributions to the photopic sinusoidal flicker electroretinogram of macaques. Documenta Ophthalmologica 105, 223242.
Wu, S. & Burns, S.A. (1996). Analysis of retinal light adaptation with the flicker electroretinogram. Journal of the Optical Society of America A 13, 649657.
Wu, S., Burns, S.A. & Elsner, A.E. (1995). Effects of flicker adaptation and retinal gain control on the flicker ERG. Vision Research 35, 29432953.


Is there an omitted stimulus response in the human cone flicker electroretinogram?

  • J. JASON McANANY (a1) and KENNETH R. ALEXANDER (a1) (a2) (a3)


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