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Identification of sodium channel subtypes induced in cultured retinal pigment epithelium cells

Published online by Cambridge University Press:  02 June 2009

Heather Dawes ,
Gail Mandel  and
Gary Matthews
Heather Dawes
Affiliation:
Department of Neurobiology and Behavior, State University of New York, Stony Brook
Gail Mandel
Affiliation:
Department of Neurobiology and Behavior, State University of New York, Stony Brook
Gary Matthews
Affiliation:
Department of Neurobiology and Behavior, State University of New York, Stony Brook
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Abstract

Recent electrophysiological experiments have shown that retinal pigment epithelium (RPE) cells begin to produce neuronal-type voltage-dependent sodium currents when placed in dissociated cell culture. In this study, the sodium channel types induced in cultured rat RPE cells were identified. Sodium channel mRNAs encoding two distinct alpha subunits were detected in the cultured RPE cells, brain type II/IIA, and a novel rat mRNA which we have termed RET1. These two sodium channel types may correspond to the TTX-sensitive and TTX-insensitive components of sodium current reported previously in cultured rat RPE cells.

Keywords

Sodium channelRetinal pigment epitheliumMolecular biologyRetina
Type
Short Communications
Information
Visual Neuroscience , Volume 12 , Issue 5 , September 1995 , pp. 1001 - 1005
Copyright
Copyright © Cambridge University Press 1995

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