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Does early enucleation affect the decussation pattern of alpha cells in the ferret?

  • Benjamin E. Reese (a1) and Janal L. Urich (a1)

Abstract

Naturally occurring cell death has been hypothesized to sculpt various features of the organization of the mature visual pathways, including the recent proposal that the selective elimination of ganglion cells in the temporal retina shapes the formation of decussation patterns. Through a class-specific interocular competition, ganglion cells in the two temporal hemiretinae are selectively lost to produce the decussation patterns characteristic of each individual cell class (Leventhal et al., 1988). The present study has tested this hypothesis by asking whether the removal of one retina in newborn ferrets, which should disrupt binocular interactions at the level of the terminals, alters the decussation pattern of the alpha cells, a cell class that is entirely decussating in the normal adult ferret. Enucleation on the day of birth was found to increase the uncrossed projection by ≈50%, but not a single uncrossed alpha cell was found in the temporal retina. Either alpha cells never project ipsilaterally during development, or if they do, they cannot be rescued by early enucleation. While naturally occurring cell death plays many roles during development, creating the decussation pattern of the ferreth's alpha cell class via a binocular competition at the level of the targets is unlikely to be one of them.

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Baker, G.E. (1990). Prechiasmatic reordering of fibre diameter classes in the retinofugal pathway of ferrets. European Journal of Neuroscience 2, 2433.
Baker, G.E. & Reese, B.E. (1993). Chiasmatic course of temporal retinal axons in the developing ferret. Journal of Comparative Neurology 330, 95104.
Baker, G.E. & Stryker, M.P. (1991). Absence of a rapidly-conducting component from the ipsilateral retinofugal pathway of ferrets. Society for Neuroscience Abstracts 17, 111.
Chalupa, L.M. & Lia, B. (1991). The nasotemporal division of retinal ganglion cells with crossed and uncrossed projections in the fetal rhesus monkey. Journal of Neuroscience 11, 191202.
Chan, S.-O. & Jen, L.S. (1988). Enlargement of uncrossed retinal projections in the albino rat: Additive effects of neonatal eye removal and thalamectomy. Brain Research 461, 163168.
Cowan, W.M., Fawcett, J.W., O'Leary, D.D.M. & Stanfield, B.B. (1984). Regressive events in neurogenesis. Science 225, 12581265.
Cucchiaro, J. & Guillery, R.W. (1984). The development of the retinogeniculate pathways in normal and albino ferrets. Proceedings of the Royal Society B (London) 223, 141164.
Cucchiaro, J.B. (1991). Early development of the retinal line of decussation in normal and albino ferrets. Journal of Comparative Neurology 312, 193206,
Dreher, B. & Robinson, S.R. (1988). Development of the retinofugal pathway in birds and mammals: Evidence for a common timetable. Brain, Behavior, and Evolution 31, 369390.
Finlay, B.L. & Pallas, S.L. (1989). Control of cell number in the developing mammalian visual system. Progress in Neurobiology 32, 207234.
Godement, P., Salaun, J. & Metin, C. (1987). Fate of uncrossed retinal projections following early or late prenatal monocular enucleation in the mouse. Journal of Comparative Neurology 225, 97109.
Hanker, J.S., Yates, P.E., Metz, C.B. & Rustioni, A.J. (1977). A new, specific, and non-carcinogenic reagent for the demonstration of horseradish peroxidase. Histochemistry Journal 9, 789792.
Henderson, Z., Finlay, B.L. & Wikler, K.C. (1988). Development of ganglion cell topography in ferret retina. Journal of Neuroscience 8, 11941205.
Hsiao, K. (1984). Bilateral branching contributes minimally to the enhanced ipsilateral projection in monocular Syrian golden hamsters. Journal of Neuroscience 4, 368373.
Insausti, R., Blakemore, C. & Cowan, W.M. (1984). Ganglion cell death during development of ipsilateral retino-collicular projection in golden hamster. Nature 308, 362364.
Jeffery, G. (1984). Retinal ganglion cell death and terminal field retraction in the developing rodent visual system. Developmental Brain Research 13, 8197.
Jeffery, G. & Perry, V.H. (1982). Evidence for ganglion cell death during development of the ipsilateral retinal projection in the rat. Developmental Brain Research 2, 176180.
Kirby, M.A. & Chalupa, L.M. (1986). Retinal crowding alters the morphology of alpha ganglion cells. Journal of Comparative Neurology 251, 532541.
Leventhal, A.G., Schall, J.D., Ault, S.J., Provis, J.M. & Vitek, D.J. (1988). Class-specific cell death shapes the distribution and pattern of central projection of cat retinal ganglion cells. Journal of Neuroscience 8, 20112027.
Linden, D.C., Guillery, R.W. & Cucchiaro, J. (1981). The dorsal lateral geniculate nucleus of the normal ferret and its postnatal development. Journal of Comparative Neurology 203, 189211.
Linden, R. & Perry, V.H. (1982). Ganglion cell death within the developing retina: A regulatory role for retinal dendrites? Neuroscience 7, 28132837.
Linden, R. & Serfaty, C.A. (1985). Evidence for differential effects of terminal and dendritic competition upon developmental neuronal death in the retina. Neuroscience 15, 853868.
Ng, A.Y.K. & Stone, J. (1982). The optic nerve of the cat: Appearance and loss of axons during normal development. Developmental Brian Research 5, 263271.
Provis, J.M. & Penfold, P.L. (1988). Cell death and the elimination of retinal axons during development. Progress in Neurobiology 31, 331347.
Ramoa, A.S., Campbell, G. & Shatz, C.J. (1988). Dendritic growth and remodeling of cat retinal ganglion cells during fetal and postnatal development. Journal of Neuroscience 8, 42394261.
Reese, B.E. & Baker, G.E. (1990). The course of fibre diameter classes through the chiasmatic region in the ferret. European Journal of Neuroscience 2, 3449.
Reese, B.E. & Cowey, A. (1986). Large retinal ganglion cells in the rat: Their distribution and laterality of projection. Experimental Brain Research 61, 375385.
Reese, B.E., Guillery, R.W. & Mallarino, C. (1992). Time of ganglion cell genesis in relation to the chiasmatic pathway choice of retinofugal axons. Journal of Comparative Neurology 324, 336342.
Reese, B.E., Guillery, R.W., Marzi, C.A. & Tassinari, G. (1991). Position of axons in the cat's optic tract in relation to their retinal origin and chiasmatic pathway. Journal of Comparative Neurology 306, 539553.
Reese, B.E., Thompson, W.F. & Peduzzi, J.D. (1994). Birthdates of neurons in the retinal ganglion cell layer of the ferret. Journal of Comparative Neurology 341, 464475.
Robinson, S.R. (1991). Development of the mammalian retina. In Neuroanatomy of the Visual Pathways and Their Development, ed. Dreher, B. & Robinson, S.R., pp. 69128. London: Macmillan.
Thompson, I.D. & Morgan, J.E. (1993). The development of retinal ganglion cell decussation patterns in postnatal pigmented and albino ferrets. European Journal of Neuroscience 5, 341356.
Thompson, I.D., Morgan, J.E. & Henderson, Z. (1993). The effects of monocular enucleation on ganglion cell number and terminal distribution in the ferret's retinal pathway. European Journal of Neuroscience 5, 357367.
Vitek, D.J., Schall, J.D. & Leventhal, A.G. (1985). Morphology, central projections, and dendritic field orientation of retinal ganglion cells in the ferret. Journal of Comparative Neurology 241, 111.
Walsh, C. & Polley, E.H. (1985). The topography of ganglion cell production in the cat's retina. Journal of Neuroscience 5, 741750.
Walsh, C, Polley, E.H., Hickey, T.L. & Guillery, R.W. (1983). Generation of cat retinal ganglion cells in relation to central pathways. Nature 302, 611614.
Williams, R.W., Bastiani, M.J., Lia, B. & Chalupa, L.M. (1986). Growth cones, dying axons, and developmental fluctuations in the fiber populations of the cat's optic nerve. Journal of Comparative Neurology 246, 3269.
Wingate, R.J.T., FitzGibbon, T. & Thompson, I.D. (1992). Lucifer yellow, retrograde tracers, and fractal analysis characterise adult ferret retinal ganglion cells. Journal of Comparative Neurology 323, 449474.

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Does early enucleation affect the decussation pattern of alpha cells in the ferret?

  • Benjamin E. Reese (a1) and Janal L. Urich (a1)

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