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Update on Osaka University Twin Registry: An Overview of Multidisciplinary Research Resources and Biobank at Osaka University Center for Twin Research

  • Chika Honda (a1), Mikio Watanabe (a1) (a2), Rie Tomizawa (a1), Osaka Twin Research Group (a1) and Norio Sakai (a1) (a3)...

Abstract

The Osaka University Twin Registry was originally established as a registry of older twins but was subsequently expanded to include twins of all ages. The Center for Twin Research at Osaka University Graduate School of Medicine has been managing this registry, as well as collecting research information and bioresources from twin participants. Based on the resources, multidisciplinary research projects have been conducted in collaboration with researchers from institutions both inside and outside Japan. One of the main aims of the center is to collect research information as well as biological resources from registered twins, and to establish a biobank and databases of these data and bioresources. Although data availability may vary, the following data have been collected: physical data (e.g., height, body weight, blood pressure, theoretical visceral fat, pulse wave velocity and bone density); epidemiological data (e.g., medical history, lifestyle, quality of life, mood status, cognitive function and nutritional status); electrocardiography, ultrasonography (carotid artery and thyroid); dentistry, dermatological assessment; positron emission tomography; magnetoencephalographam; brain magnetic resonance imaging (MRI); and functional MRI. In addition to these in-person survey data, microbiome data have been collected from some participants. As for bioresources, peripheral blood is obtained from the participants for isolation of serum and extraction of DNA and RNA, then stored in deep freezers for further analyses. A variety of research projects are in progress and more are on the way both in Japan and internationally using these data.

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Corresponding author

Author for correspondence: Norio Sakai, Email: norio@sahs.med.osaka-u.ac.jp

References

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Araki, T., Hirata, M., Sugata, H., Yanagisawa, T., Onishi, M., Watanabe, Y., … Yorifuji, S. (2014). Genetic and environmental influences on motor function: A magnetoencephalographic study of twins. Frontiers in Human Neuroscience, 8, 455.
Araki, T., Hirata, M., Yanagisawa, T., Sugata, H., Onishi, M., Watanabe, Y., … Iwatani, Y. (2016). Language-related cerebral oscillatory changes are influenced equally by genetic and environmental factors. Neuroimage, 142, 241247.
Fujiwara, Y., Suzuki, H., Yasunaga, M., Sugiyama, M., Ijuin, M., Sakuma, N., … Ishii, K. (2010). Brief screening tool for mild cognitive impairment in older Japanese: Validation of the Japanese version of the Montreal Cognitive Assessment. Geriatrics & Gerontology International, 10, 225232.
Hayakawa, K., Kato, K., Onoi, M., Cai, Y. P., Kanamori, M., Doi, S., … Kadota, K. (2006). The Osaka University Aged Twin Registry: Epigenetics and identical twins discordant for aging-dependent diseases. Twin Research and Human Genetics, 9, 808810.
Hayakawa, K., Kato, K., Onoi, M., Hayashi, C., Cai, Y. P., Kanamori, M., … Kadota, K. (2006). The Japanese study of adult twins reared apart and growing old separately. Twin Research and Human Genetics, 9, 806807.
Hayakawa, K., Iwatani, Y., & Osaka Twin Research Group. (2013). An overview of multidisciplinary research resources at the Osaka University Center for Twin Research. Twin Research and Human Genetics, 16, 217220.
Hayakawa, K., Shimizu, T., Kato, K., Onoi, M., & Kobayashi, Y. (2002). A gerontological cohort study of aged twins: The Osaka University Aged Twin Registry. Twin Research, 5, 387388.
Hosomi, K., Ohno, H., Murakami, H., Natsume-Kitatani, Y., Tanisawa, K., Hirata, S., … Kunisawa, J. (2017). Method for preparing DNA from feces in guanidine thiocyanate solution affects 16S rRNA-based profiling of human microbiota diversity. Scientific Reports, 7, 4339.
Ichibori, R., Fujiwara, T., Tanigawa, T., Kanazawa, S., Shingaki, K., Torii, K., … Hosokawa, K. (2014). Objective assessment of facial skin aging and the associated environmental factors in Japanese monozygotic twins. Journal of Cosmetic Dermatology, 13, 158163.
Ikebe, K., Watkins, C. A., Ettinger, R. L., Sajima, H., & Nokubi, T. (2004). Application of short-form oral health impact profile on elderly Japanese. Gerodontology, 21, 167176.
Kanehisa, T., & Fukamachi, K. (1983). Cornell medical index — Health questionnaire (Japanese ed.). Kyoto, Japan: Sankyobo.
Kobayashi, S., Murakami, K., Sasaki, S., Okubo, H., Hirota, N., Notsu, A., … Date, C. (2011). Comparison of relative validity of food group intakes estimated by comprehensive and brief-type self-administered diet history questionnaires against 16 d dietary records in Japanese adults. Public Health Nutrition, 14, 12001211.
Kurushima, Y., Ikebe, K., Matsuda, K. I., Enoki, K., Ogata, S., Yamashita, M., … Maeda, Y. (2015a). Examination of the relationship between oral health and arterial sclerosis without genetic confounding through the study of older Japanese twins. PloS One, 10, e0127642.
Kurushima, Y., Ikebe, K., Matsuda, K., Enoki, K., Ogata, S., Yamashita, M., … Maeda, Y. (2015b). Influence of genetic and environmental factors on oral diseases and function in aged twins. Journal of Oral Rehabilitation, 42, 4956.
Lukies, M. W., Watanabe, Y., Tanaka, H., Takahashi, H., Ogata, S., Omura, K., … Osaka University Twin Research Group. (2017). Heritability of brain volume on MRI in middle to advanced age: A twin study of Japanese adults. PloS One, 12, e0175800.
Matsuda, O., Saito, M., & Sugishita, M. (1998). Cognitive deficits of mild dementia: A comparison between dementia of the Alzheimer’s type and vascular dementia. Psychiatry and Clinical Neurosciences, 52, 8791.
Ohno, Y., & Yoshimura, K. (2001). WHO-SUBI. Tokyo: Kanekoshobo.
Sasaki, S., Yanagibori, R., & Amano, K. (1998). Self-administered diet history questionnaire developed for health education: A relative validation of the test-version by comparison with 3-day diet record in women. Journal of Epidemiology, 8, 203215.
Sato, Y., Kaiba, Y., Yamaga, E., & Minakuchi, S. (2012). Reliability and validity of a Japanese version of the Oral Health Impact Profile for edentulous subjects. Gerodontology, 29, e1033e1037.
Sugishita, M., Hemmi, I., & Iwatsubo, T. (2010). Japanese versions equivalent to original English neuropsychological tests in ADNI. Alzheimer’s & Dementia, 6, S348.
Tazaki, M., & Nakane, Y. (1997). WHO QoL-26. Tokyo, Japan: Kanekoshobo.
Yokoyama, K., Araki, S., & Kawakami, N. (1990). Reliability and validity of the Japanese version of the Profile of Mood States. Japanese Journal of Public Health, 37, 913917.
Watanabe, M., Honda, C., Osaka Twin Research Group, & Iwatani, Y. (2016). Within-pair differences of DNA methylation levels between monozygotic twins are different between male and female pairs. BMC Medical Genomics, 9, 55.
Watanabe, S., Kato, H., Shimosegawa, E., & Hatazawa, J. (2013). Brain FDG-PET study in elderly twins: Metabolic similarities of brain glucose metabolism in monozygotic pairs. Journal of Nuclear Medicine, 54(Suppl. 2), 160160.
Watanabe, S., Kato, H., Shimosegawa, E., & Hatazawa, J. (2016). Genetic and environmental influences on regional brain uptake of 18F-FDG: A PET study on monozygotic and dizygotic twins. Journal of Nuclear Medicine, 57, 392397.
Watanabe, M., Takenaka, Y., Honda, C., & Iwatani, Y. (2018). Genotype-based epigenetic differences in monozygotic twins discordant for positive antithyroglobulin autoantibodies. Thyroid, 28, 110123.

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Update on Osaka University Twin Registry: An Overview of Multidisciplinary Research Resources and Biobank at Osaka University Center for Twin Research

  • Chika Honda (a1), Mikio Watanabe (a1) (a2), Rie Tomizawa (a1), Osaka Twin Research Group (a1) and Norio Sakai (a1) (a3)...

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