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Two-locus Linkage Analysis Applied to Putative Quantitative Trait Loci for Lipoprotein(a) Levels

  • Marian Beekman (a1), Bastiaan T. Heijmans (a2), Nicholas G. Martin (a3), John B. Whitfield (a4), Nancy L. Pedersen (a5), Ulf DeFaire (a6), Harold Snieder (a7), Nico Lakenberg (a8), Peter de Knijff (a9), Rune R. Frants (a10), Gert Jan B. van Ommen (a11), Cornelis Kluft (a12), George P. Vogler (a13), P. Eline Slagboom (a14) and Dorret I. Boomsma (a15)...

Abstract

Plasma levels of lipoprotein(a) — Lp(a) — are associated with cardiovascular risk (Danesh et al., 2000) and were long believed to be influenced by the LPA locus on chromosome 6q27 only. However, a recent report of Broeckel et al. (2002) suggested the presence of a second quantitative trait locus on chromosome 1 influencing Lp(a) levels. Using a two-locus model, we found no evidence for an additional Lp(a) locus on chromosome 1 in a linkage study among 483 dizygotic twin pairs.

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Copyright

Corresponding author

*Address for correspondence: Marian Beekman, Section of Molecular Epidemiology, Leiden University Medical Center, PO Box 9503, 2300 RA, Leiden, The Netherlands.

Two-locus Linkage Analysis Applied to Putative Quantitative Trait Loci for Lipoprotein(a) Levels

  • Marian Beekman (a1), Bastiaan T. Heijmans (a2), Nicholas G. Martin (a3), John B. Whitfield (a4), Nancy L. Pedersen (a5), Ulf DeFaire (a6), Harold Snieder (a7), Nico Lakenberg (a8), Peter de Knijff (a9), Rune R. Frants (a10), Gert Jan B. van Ommen (a11), Cornelis Kluft (a12), George P. Vogler (a13), P. Eline Slagboom (a14) and Dorret I. Boomsma (a15)...

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