Skip to main content Accessibility help
×
Home

Treatment Responses to Tooth Whitening in Twins

  • Patricia M. A. Corby (a1), Aaron Biesbrock (a2), Robert Gerlach (a2), Andrea L. Corby (a3), Alexandre Moreira (a3), Nicholas J. Schork (a4) and Walter A. Bretz (a1)...

Abstract

The aim of this study was to determine heritability estimates of treatment responses to a 10% hydrogen peroxide strip-based whitening system in twins. Eighty-five twin pairs were randomly assigned to 10% hydrogen peroxide whitening strips or placebo strips without peroxide. Both twins (monozygotic or dizygotic) received the same treatment. Maxillary teeth were treated for 30 minutes twice daily for 7 days. Efficacy was measured objectively as L* (light–dark), a* (red–green), and b* (yellow–blue) color change from digital images at baseline (∆) and day 8. Heritability estimates for tooth whitening treatment responses for changes from day 8 to baseline were obtained using variance-component methodologies. Whitening treatment responses were highly heritable (h2 = 71.0) for ∆b* and ∆a*(p < .0001), but not for ∆L* (h2 = 27.0), which was essentially modulated by environmental factors. This study has demonstrated that both genetic and environmental factors significantly contributed to seven-day whitening treatment responses achieved with 10% hydrogen peroxide strips.

  • View HTML
    • Send article to Kindle

      To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      Treatment Responses to Tooth Whitening in Twins
      Available formats
      ×

      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Dropbox.

      Treatment Responses to Tooth Whitening in Twins
      Available formats
      ×

      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Google Drive.

      Treatment Responses to Tooth Whitening in Twins
      Available formats
      ×

Copyright

Corresponding author

address for correspondence: Walter A. Bretz, New York University College of Dentistry, 345 East 24th Street, New York, NY 10010, USA. E-mail: wb36@nyu.edu

References

Hide All
Almasy, L., & Blangero, J. (1998). Multipoint quantitative-trait linkage analysis in general pedigrees. American Journal of Human Genetics, 62, 11981211.
Everett, E. T. (2011). Fluoride's effects on the formation of teeth and bones, and the influence of genetics. Journal of Dental Research, 90, 552560.
Ferrari, M., Kugel, G., Cagidiaco, M. C., Barker, M. L., & Gerlach, R. W. (2004). Clinical trial evaluating the peroxide concentration response of whitening strips over 28 days. American Journal of Dentistry, 17, 291294.
Gerlach, R. W., Barkerm, M. L., & Sagel, P. A. (2002). Objective and subjective whitening response of two self-directed bleaching systems. American Journal of Dentistry, 15, 712.
Gerlach, R. W., Gibb, R. D., & Sagel, P. A. (2000). A randomized clinical trial comparing a novel 5.3% hydrogen peroxide bleaching strip to 10%, 15% and 20% carbamide peroxide tray-based bleaching systems. Compendium of Continuing Education in Dentistry, 21, 2228.
Höhler, T., Reuss, E., Evers, N., Dietrich, E., Rittner, C., Freitag, C. M., . . . Fimmers, R. (2002). Differential genetic determination of immune responsiveness to hepatitis B surface antigen and to hepatitis A virus: A vaccination study in twins. Lancet, 360, 991995.
Joyner, A. (2004). Tooth colour: A review of the literature. Journal of Dentistry, 32(Suppl. 1), 312.
Luk, K., Tam, L., & Hubert, M. (2004). Effect of light energy on peroxide tooth bleaching. Journal of the American Dental Association, 135, 194201.
Odioso, L. L., Gibb, R. D., & Gerlach, R. W. (2000). Impact of demographic, behavioural, and dental care utilization parameters on tooth color and personal satisfaction. Compendium of Continuing Education in Dentistry, 21(Suppl. 29), 3541.
Qualtrough, A. J. E., & Burke, F. J. T. (1994). A look at dental esthetics. Quintessence International, 25, 714.
Simmer, J. P., & Hu, J. C.-C. (2001). Dental enamel formation and its impact on clinical dentistry. Journal of Dental Education, 65, 896905.
Simmer, J. P., Papagerakis, P., Smith, C. E., Fisher, D. C., Rountrey, A. N., Zheng, L., & Hu, J. C. (2010). Regulation of dental enamel shape and hardness. Journal of Dental Research, 89, 10241038.
Watts, A., & Addy, M. (2001). Tooth discoloration and staining: A review of the literature. British Dental Journal, 190, 309316.
Yanagawa, T., Itoh, K., Uwayama, J., Shibata, Y., Yamaguchi, A., Sano, T., . . . Yamamoto, M. (2004). Nrf2 deficiency causes tooth decolourization due to iron transport disorder in enamel organ. Gene Cells, 9, 641651.
Zhang, Y., Lundgren, T., Renvert, S., Tatakis, D. N., Firatli, E., Uygur, C., . . . Hart, T. C. (2001). Evidence of a founder effect for four cathepsin C gene mutations in Papillon-Lefevre syndrome patients. Journal of Medical Genetics, 38, 96101.

Keywords

Treatment Responses to Tooth Whitening in Twins

  • Patricia M. A. Corby (a1), Aaron Biesbrock (a2), Robert Gerlach (a2), Andrea L. Corby (a3), Alexandre Moreira (a3), Nicholas J. Schork (a4) and Walter A. Bretz (a1)...

Metrics

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed