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No Association of the Genetic Polymorphisms of Endothelial Nitric Oxide Synthase, Dimethylarginine Dimethylaminohydrolase, and Vascular Endothelial Growth Factor With Preeclampsia in Korean Populations

Published online by Cambridge University Press:  21 February 2012

Young Ju Kim*
Affiliation:
Department of Obstetrics and Gynecology, Ewha Womans University, Seoul, Korea; Medical Research Institute, Ewha Global Challenge for Medicine, Ewha Womans University, Seoul, Korea. kkyj@ewha.ac.kr
Bo Hyun Park
Affiliation:
Department of Preventive Medicine, Ewha Womans University, Seoul, Korea; Medical Research Institute, Ewha Global Challenge for Medicine, Ewha Womans University, Seoul, Korea.
Hyesook Park
Affiliation:
Department of Preventive Medicine, Ewha Womans University, Seoul, Korea; Medical Research Institute, Ewha Global Challenge for Medicine, Ewha Womans University, Seoul, Korea.
Sung-Chul Jung
Affiliation:
Department of Biochemistry, Ewha Womans University, Seoul, Korea; Medical Research Institute, Ewha Global Challenge for Medicine, Ewha Womans University, Seoul, Korea.
Myung-Geol Pang
Affiliation:
Department of Animal Science and Technology, College of Industrial Sciences, Chung-Ang University, Gyungki-Do, Korea.
Hyun-Mee Ryu
Affiliation:
Department of Obstetrics and Gynecology, Cheil General Hospital and Women's Healthcare Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Kwang-Soo Lee
Affiliation:
Division of Cardiovascular Diseases, Center for Biomedical Sciences, National Institute of Health, Seoul, Korea.
Sang-Mi Eom
Affiliation:
Division of Cardiovascular Diseases, Center for Biomedical Sciences, National Institute of Health, Seoul, Korea.
Hyun-Young Park
Affiliation:
Division of Cardiovascular Diseases, Center for Biomedical Sciences, National Institute of Health, Seoul, Korea.
*
*Address for correspondence: Young Ju Kim, M.D., Department of Obstetrics and Gynecology, Ewha Womans University, MokDong Hospital, Seoul 158-051, Korea.

Abstract

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The purpose of this study was to investigate whether there is any association between preeclampsia and eNOS, DDAH, and VEGF gene polymorphisms, and also to search for a possible association between haplotypes in eNOS, DDHA, and VEGF genes and the risk for preeclampsia. DNA was extracted from whole blood of 223 preeclampsia patients and 237 healthy pregnant women. The genotypes were analyzed by a single base primer extension assay using a SNaPShot assay kit. Results were analyzed with the Student's t-test, Chi-square test, and Logistic regression analysis. Haplotype analyses were performed using Haploview 3.2 version. There were no significant differences in genotype or allele frequencies of eNOS, DDAH, and VEGF gene polymorphisms between preeclampsia patients and controls. No increase in the risk of preeclampsia for those genes was observed under any model of inheritance and there were no statistically significant associations between any haplotypes and preeclampsia risk. Polymorphisms in eNOS, DDAH, and VEGF gene do not seem to be risk factors for preeclampsia.

Type
Articles
Copyright
Copyright © Cambridge University Press 2008