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FinnTwin12 Cohort: An Updated Review

  • Richard J. Rose (a1), Jessica E. Salvatore (a2), Sari Aaltonen (a3), Peter B. Barr (a2), Leonie H. Bogl (a3) (a4), Holly A. Byers (a2), Kauko Heikkilä (a3), Tellervo Korhonen (a3), Antti Latvala (a3) (a5), Teemu Palviainen (a3), Anu Ranjit (a6), Alyce M. Whipp (a3), Lea Pulkkinen (a7), Danielle M. Dick (a2) (a8) and Jaakko Kaprio (a3) (a6)...

Abstract

This review offers an update on research conducted with FinnTwin12 (FT12), the youngest of the three Finnish Twin Cohorts. FT12 was designed as a two-stage study. In the first stage, we conducted multiwave questionnaire research enrolling all eligible twins born in Finland during 1983–1987 along with their biological parents. In stage 2, we intensively studied a subset of these twins with in-school assessments at age 12 and semistructured poly-diagnostic interviews at age 14. At baseline, parents of intensively studied twins were administered the adult version of the interview. Laboratory studies with repeat interviews, neuropsychological tests, and collection of DNA were made of intensively studied twins during follow-up in early adulthood. The basic aim of the FT12 study design was to obtain information on individual, familial and school/neighborhood risks for substance use/abuse prior to the onset of regular tobacco and alcohol use and then track trajectories of use and abuse and their consequences into adulthood. But the longitudinal assessments were not narrowly limited to this basic aim, and with multiwave, multirater assessments from ages 11 to 12, the study has created a richly informative data set for analyses of gene–environment interactions of both candidate genes and genomewide measures with measured risk-relevant environments. Because 25 years have elapsed since the start of the study, we are planning a fifth-wave follow-up assessment.

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Copyright

This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.

Corresponding author

Author for correspondence: Richard J. Rose, Email: rose@indiana.edu

References

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Aaltonen, S., Kaprio, J., Kujala, U. M., Pulkkinen, L., Rose, R. J., & Silventoinen, K. (2018). The interplay between genes and psychosocial home environment on physical activity. Medicine & Science in Sports & Exercise, 5, 691699.
Aaltonen, S., Latvala, A., Jalenkovic, A., Rose, R. J., Kujala, U. M., Kaprio, J., & Silventoinen, K. (2019). Physical activity and academic performance: Genetic and environmental associations. Medicine & Science in Sports & Exercise. Advance online publication. doi:10.1249/MSS 0000000000002124
Aaltonen, S., Latvala, A., Rose, R. J., Kujala, U. M., Kaprio, J., & Silventoinen, K. (2016). Leisure-time physical activity and academic performance: Cross-lagged associations from adolescence to young adulthood. Scientific Reports, 15, 39215.
Araneda, D., Korhonen, T., Laatikainen, T., Haukkala, A., Rose, R. J., & Kaprio, J. (2019). Association of snus experimentation in late adolescence with daily cigarette smoking in early adulthood: A longitudinal study among Finnish men. Scandinavian Journal of Public Health. Advance online publication. doi:10.1177/1403494819828868
Bartels, M., Hendriks, A., Mauri, M., Krapohl, E., Whipp, A., Bolhuis, K., … Boomsma, D. I. (2018). Childhood aggression and the co-occurrence of behavioural and emotional problems: Results across ages 3–16 years from multiple raters in six cohorts in the EU-ACTION project. European Child & Adolescent Psychiatry, 27, 11051121.
Barr, P. B., Kuo, S. I. C., Aliev, F., Latvala, A., Viken, R., Rose, R. J., & Dick, D. M. (2019). Polygenic risk for alcohol misuse is moderated by romantic relationships. Addiction, 24, 17531762. doi:10.1111/add.14712
Barr, P. B., Salvatore, J. E., Maes, H., Aliev, F., Latvala, A., Viken, R., & Dick, D. M. (2016). Education and alcohol use: A study of gene-environment interaction in young adulthood. Social Science & Medicine, 162, 158167.
Barr, P. B., Salvatore, J. E., Maes, H. H., Korhonen, T., Latvala, A., Aliev, F., & Dick, D. M. (2017). Social relationships moderate genetic influences on heavy drinking in young adulthood. Journal of Studies on Alcohol and Drugs, 78, 817826.
Bogl, L. H., Kaye, S. M., Ramo, J. T., Kangas, A. J., Soininen, P., Hakkarainen, A., & Pietiläinen, K. H. (2016). Abdominal obesity and circulating metabolites: A twin study approach. Metabolism, 65, 111121.
Bogl, L. H., Pietilainen, K. H., Rissanen, A., Kangas, A. J., Soininen, P., Rose, R. J., & Kaprio, J. l. (2013). Association between habitual dietary intake and lipoprotein subclass profile in healthy young adults. Nutrition, Metabolism & Cardiovascular Diseases, 23, 10711078.
Bucholz, K. K., Cadoret, R., Cloninger, C. R., Dinwiddie, S. H., Hesselbrock, V. M., & Schuckit, M. A. (1994). A new, semi-structured psychiatric interview for use in genetic linkage studies: A report on the reliability of the SSAGA. Journal of Studies on Alcohol, 55, 149158.
Chassin, L., Pillow, D. R., Curran, P. J., Molina, B. S. G., & Barrera, M. (1993). Relation of parental alcoholism to early adolescent substance use: A test of 3 mediating mechanisms. Journal of Abnormal Psychology, 102, 319.
Cooke, M., Meyers, J., Latvala, A., Korhonen, T., Rose, R. J., Kaprio, J., … Dick, D. M. (2015). Gene-environment interaction effects of peer deviance, parental knowledge and stressful life events on adolescent alcohol use. Twin Research and Human Genetics, 18, 507517.
Delis, D. C., Kaplan, E., & Kramer, J. H. (2001). Delis-Kaplan executive function system (D-KEFS). San Antonio, TX: Psychological Corporation.
Depue, R. (1987). General behavior inventory. Ithaca, NY: Department of Psychology, Cornell University.
Dick, D. M., Pagan, J. L., Holliday, C., Viken, R., Pulkkinen, L., Kaprio, J., & Rose, R. J. (2007). Gender differences in friends’ influences on adolescent drinking: A genetic epidemiological study. Alcoholism: Clinical and Experimental Research, 31, 20122019.
Dick, D. M., Pagan, J. L., Viken, R., Purcell, S., Kaprio, J., Pulkkinen, L., & Rose, R. J. (2007). Changing environmental influences on substance use across development. Twin Research and Human Genetics, 10, 315326.
Dick, D. M., Riley, B., & Kendler, K. S. (2010). Nature and nurture in neuropsychiatric genetics: Where do we stand? Dialogues in Clinical Neuroscience, 12, 723.
Dick, D. M., Rose, R. J., Pulkkinen, L., & Kaprio, J. (2001). Measuring puberty and understanding its impact: A longitudinal study of adolescent twins. Journal of Youth and Adolescence, 30, 385399.
Dick, D. M., Rose, R. J., Viken, R. J., & Kaprio, J. (2000). Pubertal timing and substance use: Associations between and within families across late adolescence. Developmental Psychology, 36, 180189.
Dick, D. M., Rose, R. J., Viken, R. J., Kaprio, J., & Koskenvuo, M. (2001). Exploring gene-environment interactions: Socioregional moderation of alcohol use. Journal of Abnormal Psychology, 110, 625632.
Dick, D. M., Viken, R., Purcell, S., Kaprio, J., Pulkkinen, L., & Rose, R. J. (2007). Parental monitoring moderates the importance of genetic and environmental influences on adolescent smoking. Journal of Abnormal Psychology, 116, 213218.
Eriksson, C. J. P., Kaprio, J., Pulkkinen, L., & Rose, R. J. (2005). Testosterone and alcohol use among adolescent male twins: Testing between-family associations in within-family comparisons. Behavior Genetics, 35, 359–268.
Huizink, A., Levälahti, E., Korhonen, T., Dick, D., Pulkkinen, L., & Kaprio, J. (2010). Tobacco and cannabis and other illicit drug use among Finnish adolescent twins: Causal relationship or correlated liabilities? Journal of Studies on Alcohol and Drugs, 71, 514.
Jelenkovic, A., Bogl, L. H., Rose, R. J., Kangas, A. J., Soininen, P., Ala-Korpela, M., & Silventoinen, K. (2013). Association of height and pubertal timing with lipoprotein subclass profile: Exploring the role of genetic and environmental effects. American Journal of Human Biology, 25, 465472,
Jelenkovic, A., Bogl, L. H., Rose, R. J., Kangas, A. J., Soininen, P., Ala-Korpela, M., & Silventoinen, K. (2014). Association between serum fatty acids and lipoprotein subclass profile in healthy young adults: Exploring common genetic and environmental factors. Atherosclerosis, 233, 394402.
Kaprio, J. (2013). The Finnish twin cohort study: An update. Twin Research and Human Genetics, 16, 157162.
Kaprio, J., Bollepalli, S., Buchwald, J., Iso-Markku, P., Korhonen, T., Kovanen, V., & Waller, K. (2019). The Older Finnish Twin Cohort – Forty-five years of follow-up. Twin Research and Human Genetics. Advance online publication.
Kiecolt-Glaser, J. K., & Wilson, S. J. (2017). Lovesick: How couples’ relationships influence health. Annual Review of Clinical Psychology, 13, 421443.
Klinteberg, B., Magnusson, D., & Schalling, D. (1986). Self-report assessment of personality traits: Data from the KSP inventory on a representative sample of normal male and female subjects within a developmental project. Stockholm, Sweden: Department of Psychology, University of Stockholm.
Korhonen, T., Huizink, A., Dick, D. M., Pulkkinen, L., Rose, R. J., & Kaprio, J. (2008). Role of individual, peer and family factors in the use of cannabis and other illicit drugs: A longitudinal analysis among Finnish adolescent twins. Drug and Alcohol Dependence, 97, 3343.
Korhonen, T., Latvala, A., Dick, D. M., Pulkkinen, L., Rose, R. J., Kaprio, J., & Huizink, A. (2012). Genetic and environmental influences underlying externalizing behaviors, cigarette smoking and illicit drug use across adolescence. Behavior Genetics, 42, 614625.
Korhonen, T., Levälahti, E., Dick, D. M., Pulkkinen, L., Rose, R. J., Kaprio, J., & Huizink, A. (2010). Externalizing behaviours and cigarette smoking as predictors for use of illicit drugs: A longitudinal study among Finnish adolescent twins. Twin Research and Human Genetics, 13, 550558.
Korhonen, T., Sihvola, E., Latvala, A., Dick, D. M., Pulkkinen, L., Nurnberger, J., & Kaprio, J. (2018). Early-onset tobacco use and suicide-related behavior – A prospective study from adolescence to young adulthood. Addictive Behaviors, 79, 3238.
Korsoff, P., Bogl, L. H., Korhonen, P., Kangas, A. J., Soininen, P., Ala-Korpela, M., & Kaprio, J. (2014). A comparison of anthropometric, metabolic, and reproductive characteristics of young adult women from opposite-sex and same-sex twin pairs. Frontiers in Endocrinology, 5, 28.
Kovacs, M. (1991). The child’s depression inventory (CDI). North Tonawanda, NY: Multi Health Systems.
Kristenson, H., & Trell, E. (1982). Indicators of alcohol consumption: comparisons between a questionnaire (Mm-MAST), interviews and serum y-Glutamyl Transferase (GGT) in a health survey of middle-aged males. British Journal of Addiction, 77, 297304.
Latendresse, S. J., Rose, R. J., Pulkkinen, L., Kaprio, J., & Dick, D. M. (2010). Examining the etiology of associations between perceived parenting and adolescents’ alcohol use: Common genetic and/or environmental liabilities? Journal of Studies on Alcohol and Drugs, 71, 313325.
Latendresse, S. J., Rose, R. J., Viken, R. J., Pulkkinen, L., Kaprio, J., & Dick, D. M. (2008). Parenting mechanisms in links between parents’ and adolescents’ alcohol use behaviors. Alcoholism: Clinical and Experimental Research, 32, 322330.
Latendresse, S. J., Rose, R. J., Viken, R. J., Pulkkinen, L., Kaprio, J., & Dick, D. M. (2009). Parental socialization and adolescents’ alcohol use behaviors: Predictive disparities in parents’ versus adolescents’ perceptions of the parenting environment. Journal of Clinical Child and Adolescent Psychology, 38, 232244.
Latvala, A., Dick, D. M., Tuulio-Henriksson, A., Suvisaari, J., Viken, R. J., Rose, R. J., & Kaprio, J. (2011). Genetic correlation and gene-environment interaction between alcohol problems and educational level in young adulthood. Journal of Studies on Alcohol and Drugs, 72, 210220.
Latvala, A., Rose, R. J., Pulkkinen, L., Dick, D. M., Korhonen, T., & Kaprio, J. (2014). Drinking, smoking, and educational achievement: Cross-lagged associations from adolescence to adulthood. Drug and Alcohol Dependence, 137, 106113.
Li, J. J., Savage, J. E., Kendler, K. S., Hickman, M., Mahedy, L., Macleod, J., & Dick, D. M. (2017). Polygenic risk, personality dimensions, and adolescent alcohol use problems: A longitudinal study. Journal of Studies on Alcohol and Drugs, 78, 442451.
Meyers, J. L., Salvatore, J. E., Vuoksimaa, E., Korhonen, T., Pulkkinen, L., Rose, R. J., & Dick, D. M. (2014). Genetic influences on alcohol use behaviors have diverging trajectories: A prospective study among male and female twins. Alcoholism: Clinical & Experimental Research, 38, 28692877.
Närhi, V., Räsänen, P., Metsäpelto, R., & Ahonen, T. (1997). Trail making test in assessing children with reading disabilities: A test of executive functions or content information. Perceptual and Motor Skills, 84, 13551362.
Pagan, J. L., Rose, R. J., Viken, R. J., Pulkkinen, L., Kaprio, J., & Dick, D. M. (2006). Genetic and environmental influences on stages of alcohol use across adolescence and into young adulthood. Behavior Genetics, 36, 483497.
Pulkkinen, L. (1987). Offensive and defensive aggression inhuman: A longitudinal perspective. Aggressive Behavior, 13, 373391.
Pulkkinen, L. (2017). Human development from middle childhood to middle adulthood: Growing up to be middle-aged. London: Routledge.
Pulkkinen, L., Kaprio, J., & Rose, R. J. (1999). Peers, teachers and parents as assessors of the behavioural and emotional problems of twins and their adjustment: The Multidimensional Peer Nomination Inventory. Twin Research, 2, 274285.
Ranjit, A., Korhonen, T., Buchwald, J., Heikkilä, K., Tuulio-Henriksson, A., Rose, R. J., & Latvala, A. (2019). Testing the reciprocal association between smoking and depressive symptoms from adolescence to adulthood: A longitudinal twin study. Drug and Alcohol Dependence, 200, 6470.
Reitan, R. M., & Wolfson, D. (1993). The Halstead-Reitan neuropsychological test battery: Theory and clinical applications. Tucson, AZ: Neuropsychology Press.
Rose, R. J. (1998). A developmental behavior-genetic perspective on alcoholism risk. Alcohol Health & Research World, 22, 131143.
Rose, R. J., Dick, D. M., Viken, R. J., & Kaprio, J. (2001). Gene-environment interaction in patterns of adolescent drinking: Regional residency moderates longitudinal influences on alcohol use. Alcoholism: Clinical & Experimental Research, 25, 637643.
Rose, R. J., Dick, D. M., Viken, R. J., Pulkkinen, L., & Kaprio, J. (2001). Drinking or abstaining at age 14? A genetic epidemiological study. Alcoholism: Clinical and Experimental Research, 25, 15941604.
Rose, R. J., Viken, R. J., Dick, D. M., Bates, J., Pulkkinen, L, & Kaprio, J. (2003). It does take a village: Non-familial environments and children’s behavior. Psychological Science, 14, 273277.
Salvatore, J. E., Aliev, F., Bucholz, K., Agrawal, A., Hesselbrock, V., Hesselbrock, M., & Dick, D. M. (2015). Polygenic risk for externalizing disorders: Gene-by-development and gene-by-environment effects in adolescents and young adults. Clinical Psychological Science, 3, 189201.
Salvatore, J. E., Aliev, F., Edwards, A. C., Evans, D. M., Macleod, J., Hickman, M., & Dick, D. M. (2014). Polygenic scores predict alcohol problems in an independent sample and show moderation by the environment. Genes, 5, 330346.
Salvatore, J. E., Meyers, J. L., Yan, J., Aliev, F., Lansford, J. E., Pettit, G. S., & Dick, D. M. (2015). Intergenerational continuity in parents’ and adolescents’ externalizing problems: The role of life events and their interaction with GABRA2. Journal of Abnormal Psychology, 124, 709728.
Salvatore, J. E., Savage, J. E., Barr, P. B., Wolen, A. R., Aliev, F., Vuoksimaa, E., & Dick, D. M. (2018). Incorporating functional genomic information to enhance polygenic signal and identify variants involved in gene-by-environment interaction for young adult alcohol problems. Alcoholism: Clinical and Experimental Research, 42, 413423.
Savage, J. E., Kaprio, J., Korhonen, T., Pulkkinen, L., Rose, R. J., Verhulst, B., & Dick, D. M. (2016). The effects of social anxiety on alcohol and cigarette use across adolescence: Results from a longitudinal twin study in Finland. Psychology of Addictive Behaviors, 30, 462474.
Savage, J. E., Rose, R. J., Pulkkinen, L., Silventoinen, K., Korhonen, T., Kaprio, J., … Dick, D. M. (2018). Early maturation and substance use across adolescence and young adulthood: A longitudinal study of Finnish twins. Development and Psychopathology, 30, 7992.
Savage, J. E., Salvatore, J. E., Aliev, F., Edwards, A. C., Hickman, M., Kendler, K. S., & Dick, D. M. (2018). Polygenic risk score prediction of alcohol dependence symptoms across population-based and clinically ascertained samples. Alcoholism: Clinical and Experimental Research, 42, 520530.
Schulenberg, J. E., Patrick, M. E., Kloska, D. D., Maslowsky, J., Maggs, J. L., & O’Malley, P. M. (2015). Substance use disorder in early midlife: A national prospective study on health and well-being correlates and long-term predictors. Substance Abuse, 9(Suppl. 1), 4157.
Shanahan, M. J., & Hofer, S. M. (2005). Social context in gene-environment interactions: retrospect and prospect. Journals of Gerontology Series B-Psychological Sciences and Social Sciences, 60, 6576.
Silventoinen, K., Posthuma, D., Lahelma, E., Rose, R. J., & Kaprio, J. (2007). Genetic and environmental factors affecting self-rated health from age 16–25: a longitudinal study of Finnish twins. Behavior Genetics, 37, 326333.
Silventoinen, K., Su, J., Barr, P. B., Rose, R. J., Dick, D. M., & Kaprio, J. (2019). Genetics of perceived family interaction from 12 to 17 years of age. Behavior Genetics, 49, 366375.
Verhulst, B., Neale, M. C., & Kendler, K. S. (2015). The heritability of alcohol use disorders: A meta-analysis of twin and adoption studies. Psychological Medicine, 45, 10611072.
Verweij, K. J. H., Creemers, H. E., Korhonen, T., Latvala, A., Dick, D. M., Rose, R. J., … Kaprio, J. (2016). Role of overlapping genetic and environmental factors in the relationship between early adolescent conduct problems and substance use in young adulthood. Addiction, 111, 10361045.
Wechsler, D. (1987). Wechsler memory scale – revised manual. San Antonio, TX: Psychological Corporation.
Wechsler, D. (1997). WAIS-3: Wechsler Adult Intelligence Scale: Administration and scoring manual. San Antonio, TX: Psychological Corporation.
Whipp, A., Vuoksimaa, E., Bolhuis, K., de Zeeuw, E. L., Korhonen, T., Mauri, M., & Boomsma, D. I. (2019). Teacher-rated aggression and co-occurring behaviors among schoolchildren: A comparison of four population-based European cohorts, in review.
Whipp, A. M., Korhonen, T., Raevuori, A., Heikkilä, K., Pulkkinen, L., Rose, R. J., … Vuoksimaa, E. (2019). Early adolescent aggression predicts antisocial personality disorder in young adults: A population-based study. European Child & Adolescent Psychiatry, 28, 341350.
Windle, M. (2010). A multilevel developmental contextual approach to substance use and addiction. Biosocieties, 5, 124136.

Keywords

FinnTwin12 Cohort: An Updated Review

  • Richard J. Rose (a1), Jessica E. Salvatore (a2), Sari Aaltonen (a3), Peter B. Barr (a2), Leonie H. Bogl (a3) (a4), Holly A. Byers (a2), Kauko Heikkilä (a3), Tellervo Korhonen (a3), Antti Latvala (a3) (a5), Teemu Palviainen (a3), Anu Ranjit (a6), Alyce M. Whipp (a3), Lea Pulkkinen (a7), Danielle M. Dick (a2) (a8) and Jaakko Kaprio (a3) (a6)...

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