Skip to main content Accessibility help
×
Home

Depression, Neuroticism, and Urinary Incontinence in Premenopausal Women: A Nationwide Twin Study

  • Giorgio Tettamanti (a1), Daniel Altman (a1) (a2), Anastasia N. Iliadou (a1), Rino Bellocco (a1) (a3) and Nancy L. Pedersen (a1)...

Abstract

Previous studies have found that major depression and neuroticism are positively associated with urinary incontinence (UI). However, the genetic contribution to these associations has never been investigated. In 2005, a total of 14,094 female twins born 1959–1985 in the Swedish Twin Registry participated in a comprehensive survey on common exposures and complex diseases. Structured questions provided information on UI, depressive symptoms, major depression, and neuroticism. A logistic regression model based on generalized estimating equations (GEE) was used to estimate odds ratios (ORs) with 95% confidence intervals (CIs). Environmental and genetic influences were assessed in co-twin control analyses and quantitative genetic analyses, which were also used to determine the proportion of the phenotypic correlation explained by familial factors. Major depression, depressive symptoms, and neuroticism were positively associated with all UI subtypes (overall, stress, urge, and mixed UI). In a trivariate Cholesky model with neuroticism, depressive symptoms (or depression), and UI a modest genetic correlation was found between indicators of depression and overall, or stress, UI. The majority of this correlation was independent from neuroticism. In contrast, the genetic factors shared between indicators of depression and urge or mixed UI were entirely in common with neuroticism. In conclusion, depression and neuroticism are associated with UI among premenopausal women: the associations are in part determined by genetic factors in common to the disorders.

  • View HTML
    • Send article to Kindle

      To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      Depression, Neuroticism, and Urinary Incontinence in Premenopausal Women: A Nationwide Twin Study
      Available formats
      ×

      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Dropbox.

      Depression, Neuroticism, and Urinary Incontinence in Premenopausal Women: A Nationwide Twin Study
      Available formats
      ×

      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Google Drive.

      Depression, Neuroticism, and Urinary Incontinence in Premenopausal Women: A Nationwide Twin Study
      Available formats
      ×

Copyright

Corresponding author

address for correspondence: Giorgio Tettamanti, Department of Medical Epidemiology and Biostatistics, 171 77 Karolinska Institutet, Stockholm, Sweden. E-mail: giorgio.tettamanti@ki.se

References

Hide All
Abrams, P., Cardozo, L., Fall, M., Griffiths, D., Rosier, P., Ulmsten, U., . . . Wein, A. (2003). The standardisation of terminology in lower urinary tract function: Report from the standardisation sub-committee of the International Continence Society. Urology, 61, 3749.
Abrams, P., Cardozo, L., Khoury, S., & Wein, A. (Eds.). (2009). Incontinence: 4th international consultation on incontinence, Paris July 5–8, 2008. Plymouth, UK: Health Publications Ltd.
Altman, D., Forsman, M., Falconer, C., & Lichtenstein, P. (2008). Genetic influence on stress urinary incontinence and pelvic organ prolapse. European Urology, 54, 918922.
American Psychiatric Association (APA). (2000). Diagnostic and statistical manual of mental disorders: DSM-IV-TR. Washington DC: Author.
Bouchard, T. J. (2004). Genetic influence on human psychological traits — A survey. Current Directions in Psychological Science, 13, 148151.
Floderus, B. (1974). Psycho-social factors in relation to coronary heart disease and associated risk factors. Nordisk Hygienisk Tidskrift (Monograph, Suppl. 6), 1148.
Hannestad, Y. S., Lie, R. T., Rortveit, G., & Hunskaar, S. (2004). Familial risk of urinary incontinence in women: Population based cross sectional study. BMJ, 329, 889891.
Hannestad, Y. S., Rortveit, G., Sandvik, H., & Hunskaar, S. (2000). A community-based epidemiological survey of female urinary incontinence: The Norwegian EPINCONT study. Epidemiology of incontinence in the county of Nord-Trondelag. Journal of Clinical Epidemiology, 53, 11501157.
Kessler, R. C., Andrews, G., Mroczek, D. Z., Ustun, B., & Wittchen, H.-U. (1998). The World Health Organization Composite International Diagnostic Interview short-form (CIDI-SF). International Journal of Methods in Psychiatric Research, 7, 171185.
Kessler, R. C., McGonagle, K. A., Zhao, S., Nelson, C. B., Hughes, M., Eshleman, S., . . . Kendler, K. S. (1994). Lifetime and 12-month prevalence of DSM-III-R psychiatric disorders in the United States. Results from the National Comorbidity Survey. Archives of General Psychiatry, 51, 819.
Kohout, F. J., Berkman, L. F., Evans, D. A., & Cornoni-Huntley, J. (1993). Two shorter forms of the CES-D (Center for Epidemiological Studies Depression) depression symptoms index. Journal of Aging and Health, 5, 179193.
Lichtenstein, P., De Faire, U., Floderus, B., Svartengren, M., Svedberg, P., & Pedersen, N. L. (2002). The Swedish Twin Registry: A unique resource for clinical, epidemiological and genetic studies. Journal of Internal Medicine, 252, 184205.
Lichtenstein, P., Sullivan, P. F., Cnattingius, S., Gatz, M., Johansson, S., Carlstrom, E., . . . Pedersen, N. L. (2006). The Swedish Twin Registry in the third millennium: An update. Twin Research and Human Genetics, 9, 875882.
Loehlin, J. C. (1992). Genes and environment in personality development. Newbury Park, CA: Sage Publications.
Melville, J. L., Fan, M. Y., Rau, H., Nygaard, I. E., & Katon, W. J. (2009). Major depression and urinary incontinence in women: Temporal associations in an epidemiologic sample. American Journal of Obstetrics and Gynecology, 201, 490.e491497.
Melville, J. L., Katon, W., Delaney, K., & Newton, K. (2005). Urinary incontinence in US women: A population-based study. Archives of Internal Medicine, 165, 537542.
Moghaddas, F., Lidfeldt, J., Nerbrand, C., Jernstrom, H., & Samsioe, G. (2005). Prevalence of urinary incontinence in relation to self-reported depression, intake of serotonergic antidepressants, and hormone therapy in middle-aged women: A report from the Women's Health in the Lund Area study. Menopause, 12, 318324.
Morrison, L. M., Eadie, A. S., McAlister, A., Glen, E. S., Taylor, J., & Rowan, D. (1986). Personality testing in 226 patients with urinary incontinence. British Journal of Urology, 58, 387389.
Neale, M. C., Bocker, S. M., Xie, G., & Maes, H. H. (1999). Mx: Statistical modeling (5th edition). Richmond, VI: Department of Psychiatry, Medical College of Virginia, Virginia Commonwealth University.
Neale, M. C., & Cardon, L. R. (1992). Methodology for genetic studies of twins and families. Dordrecht, the Netherlands: Kluwer Academic.
Nemeroff, C. B. (1998). The neurobiology of depression. Scientific American, 278, 4249.
Radloff, L. S. (1977). The CES-D Scale: A self-report depression scale for research in the general population. Applied Psychological Measurement, 1, 385401.
Rohr, G., Kragstrup, J., Gaist, D., & Christensen, K. (2004). Genetic and environmental influences on urinary incontinence: A Danish population-based twin study of middle-aged and elderly women. Acta Obstetricia et Gynecologica Scandinavica, 83, 978982.
Spector, T. (2000). Advances in twin and sib-pair analysis. London: Greenwich Medical Media.
Steers, W. D., & Lee, K. S. (2001). Depression and incontinence. World Journal of Urology, 19, 351357.
Sullivan, P. F., Neale, M. C., & Kendler, K. S. (2000). Genetic epidemiology of major depression: Review and meta-analysis. American Journal of Psychiatry, 157, 15521562.
Thom, D. H., Haan, M. N., & Van Den Eeden, S. K. (1997). Medically recognized urinary incontinence and risks of hospitalization, nursing home admission and mortality. Age and Ageing, 26, 367374.
Wennberg, A. L., Altman, D., Lundholm, C., Klint, A., Iliadou, A., Peeker, R., . . . Milsom, I. (2011). Genetic influences are important for most but not all lower urinary tract symptoms: A population-based survey in a cohort of adult Swedish twins. European Urology, 59, 10321038.
Yarnell, J. W., Voyle, G. J., Sweetnam, P. M., Milbank, J., Richards, C. J., & Stephenson, T. P. (1982). Factors associated with urinary incontinence in women. Journal of Epidemiology and Community Health, 36, 5863.
Zorn, B. H., Montgomery, H., Pieper, K., Gray, M., & Steers, W. D. (1999). Urinary incontinence and depression. Journal of Urology, 162, 8284.

Keywords

Related content

Powered by UNSILO
Type Description Title
WORD
Supplementary materials

Tettamanti Supplementary Material
Table

 Word (16 KB)
16 KB
WORD
Supplementary materials

Tettamanti Supplementary Material
Table

 Word (19 KB)
19 KB
WORD
Supplementary materials

Tettamanti Supplementary Material
Table

 Word (15 KB)
15 KB

Depression, Neuroticism, and Urinary Incontinence in Premenopausal Women: A Nationwide Twin Study

  • Giorgio Tettamanti (a1), Daniel Altman (a1) (a2), Anastasia N. Iliadou (a1), Rino Bellocco (a1) (a3) and Nancy L. Pedersen (a1)...

Metrics

Altmetric attention score

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed.