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The Danish Twin Registry: Linking Surveys, National Registers, and Biological Information

  • Axel Skytthe (a1), Lene Christiansen (a1) (a2), Kirsten Ohm Kyvik (a1) (a3) (a4), Frans L. Bødker (a1), Lars Hvidberg (a1), Inge Petersen (a1), Morten M. F. Nielsen (a1), Paul Bingley (a1) (a5), Jacob Hjelmborg (a1) (a6), Qihua Tan (a1) (a2), Niels V. Holm (a1) (a7), James W. Vaupel (a1) (a8), Matt McGue (a1) (a9) and Kaare Christensen (a1) (a2) (a10)...

Abstract

Over the last 60 years, the resources and the research in the Danish Twin Registry (DTR) have periodically been summarized. Here, we give a short overview of the DTR and a more comprehensive description of new developments in the twenty-first century. First, we outline our experience over the last decade of combining questionnaire and survey data with national demographic, social, and health registers in Statistics Denmark. Second, we describe our most recent data collection effort, which was conducted during the period 2008–2011 and included both in-person assessments of 14,000+ twins born 1931–1969 and sampling of biological material, hereby expanding and consolidating the DTR biobank. Third, two examples of intensively studied twin cohorts are given. The new developments in the DTR in the last decade have facilitated the ongoing research and laid the groundwork for new research directions.

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Copyright

Corresponding author

address for correspondence: Kaare Christensen, The Danish Twin Registry, Epidemiology, Institute of Public Health, University of Southern Denmark, J. B. Winsløws Vej 9B, DK-5000 Odense, Denmark. E-mail: kchristensen@health.sdu.dk

References

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Bathum, L., Fagnani, C., Christiansen, L., & Christensen, K. (2004). Heritability of biochemical kidney markers and relation to survival in the elderly: Results from a Danish population-based twin study. Clinica Chimica Acta, 349, 143150.
Benyamin, B., Sorensen, T. I., Schousboe, K., Fenger, M., Visscher, P. M., & Kyvik, K. O. (2007). Are there common genetic and environmental factors behind the endophenotypes associated with the metabolic syndrome? Diabetologia, 50, 18801888.
Christensen, K., Bathum, L., & Christiansen, L. (2008). Biological indicators and genetic information in Danish twin and oldest-old surveys. In Weinstein, M., Vaupel, J. W. & Wachter, K. W. (Eds.), Biosocial surveys (pp. 1541). Washington DC: The National Academies Press.
Christensen, K., Holm, N. V., McGue, M., Corder, L., & Vaupel, J. W. (1999). A Danish population-based twin study on general health in the elderly. Journal of Aging and Health, 11, 4964.
Christensen, K., Kyvik, K. O., Holm, N. V., & Skytthe, A. (2011). Register-based research on twins. Scandinavian Journal of Public Health, 39, 185190.
Christensen, K., Petersen, I., Skytthe, A., Herskind, A. M., McGue, M., & Bingley, P. (2006). Comparison of academic performance of twins and singletons in adolescence: Follow-up study. BMJ, 333, 10951097.
Christiansen, L., Frederiksen, H., Schousboe, K., Skytthe, A., von Wurmb-Schwark, N., Christensen, K., & Kyvik, K. (2003). Age- and sex-differences in the validity of questionnaire-based zygosity in twins. Twin Research, 6, 275278.
Fenger, M., Benyamin, B., Schousboe, K., Sorensen, T. I., & Kyvik, K. O. (2007). Variance decomposition of apolipoproteins and lipids in Danish twins. Atherosclerosis, 191, 4047.
Frost, M., Petersen, I., Brixen, K., Beck-Nielsen, H., Holst, J. J., Christiansen, L., . . . Christensen, K. (in press-a). Adult glucose metabolism in extremely birth weight discordant monozygotic twins. Diabetologia. doi:10.1007/s00125-012-2695-x. First published online 07 Sept 2012.
Frost, M., Petersen, I., Hegedus, L., Christiansen, L., Heiberg, B. T., & Christensen, K. (in press-b). Regulation of the pituitary-thyroid axis in adulthood is not related to birth weight. Evidence from extremely birth weight discordant monozygotic danish twin pairs. Thyroid. doi:10.1089/thy.2012-0095.
Gaist, D., Bathum, L., Skytthe, A., Jensen, T. K., McGue, M., Vaupel, J. W., & Christensen, K. (2000). Strength and anthropometric measures in identical and fraternal twins: No evidence of masculinization of females with male co-twins. Epidemiology, 11, 340343.
Harvald, B., & Hauge, G. (1999). The early history of the Danish twin registry. Dansk Medicinhistorisk Aarbog/Årbog., 81106.
Harvald, B., Hauge, G., Kyvik, K. O., Christensen, K., Skytthe, A., & Holm, N. V. (2004). The Danish Twin Registry: Past and present. Twin Research, 7, 318335.
Hasselbalch, A. L., Benyamin, B., Visscher, P. M., Heitmann, B. L., Kyvik, K. O., & Sorensen, T. I. (2008). Common genetic components of obesity traits and serum leptin. Obesity (Silver.Spring), 16, 27232729.
Hauge, M. (1981). The Danish Twin Registry. In Mednick, S. A., Baert, A. E. & Bachmann, B. P. (Eds.), Prospective longitudinal research. An empirical basis for the primary prevention of psychosocial disorders (pp. 217221). Oxford: Oxford University Press.
Kettunen, J., Perola, M., Martin, N. G., Cornes, B. K., Wilson, S. G., Montgomery, G. W., . . . Peltonen, L. (2009). Multicenter dizygotic twin cohort study confirms two linkage susceptibility loci for body mass index at 3q29 and 7q36 and identifies three further potential novel loci. International Journal of Obesity, 33, 12351242.
Kyvik, K. O., Christensen, K., Skytthe, A., Harvald, B., & Holm, N. V. (1996). The Danish Twin Register. Danish Medical Bulletin, 43, 467470.
Lachman, M. E. (2001). Handbook of midlife development. New York: John Wiley and Sons.
Madsen, M., Andersen, A. M., Christensen, K., Andersen, P. K., & Osler, M. (2010). Does educational status impact adult mortality in Denmark? A twin approach. American Journal of Epidemiology, 172, 225234.
McGue, M., & Christensen, K. (2007). Social activity and healthy aging: A study of aging Danish twins. Twin Research & Human Genetics, 10, 255265.
McGue, M., Osler, M., & Christensen, K. (2010). Causal inference and observational research: The utility of twins. Perspectives on Psychological Science, 5, 546556.
Oksuzyan, A., Petersen, I., Stovring, H., Bingley, P., Vaupel, J. W., & Christensen, K. (2009). The male-female health-survival paradox: A survey and register study of the impact of sex-specific selection and information bias. Annals of Epidemiology, 19, 504511.
Petersen, I., Martinussen, T., McGue, M., Bingley, P., & Christensen, K. (2011a). Lower marriage and divorce rates among twins than among singletons in Danish birth cohorts 1940-1964. Twin Research & Human Genetics, 14, 150157.
Petersen, I., Nielsen, M. M., Beck-Nielsen, H., & Christensen, K. (2011b). No evidence of a higher 10 year period prevalence of diabetes among 77,885 twins compared with 215,264 singletons from the Danish birth cohorts 1910–1989. Diabetologia, 54, 20162024.
Roth, M., Tym, E., Mountjoy, C. Q., Huppert, F. A., Hendrie, H., Verma, S., & Goddard, R. (1986). CAMDEX. A standardised instrument for the diagnosis of mental disorder in the elderly with special reference to the early detection of dementia. British Journal of Psychiatry, 149, 698709.
Schousboe, K., Visscher, P. M., Erbas, B., Kyvik, K. O., Hopper, J. L., Henriksen, J. E., . . . Sørensen, T. I. (2004). Twin study of genetic and environmental influences on adult body size, shape, and composition. International Journal of Obesity and Related Metabolic Disorders, 28, 3948.
Schousboe, K., Visscher, P. M., Henriksen, J. E., Hopper, J. L., Sorensen, T. I., & Kyvik, K. O. (2003). Twin study of genetic and environmental influences on glucose tolerance and indices of insulin sensitivity and secretion. Diabetologia, 46, 12761283.
Skytthe, A., Kyvik, K. O., Holm, N. V., & Christensen, K. (2011). The Danish Twin Registry. Scandinavian Journal of Public Health, 39, 7578.
Skytthe, A., Kyvik, K., Holm, N. V., Vaupel, J. W., & Christensen, K. (2002). The Danish Twin Registry: 127 birth cohorts of twins. Twin Research, 5, 352357.
Svendsen, A. J., Hjelmborg, J. V., Wiik, A., Houen, G., Kyvik, K. O., & Junker, P. (2011). Autoantibodies in twins discordant for rheumatoid arthritis. Annals of the Rheumatic Diseases, 70, 708709.

Keywords

The Danish Twin Registry: Linking Surveys, National Registers, and Biological Information

  • Axel Skytthe (a1), Lene Christiansen (a1) (a2), Kirsten Ohm Kyvik (a1) (a3) (a4), Frans L. Bødker (a1), Lars Hvidberg (a1), Inge Petersen (a1), Morten M. F. Nielsen (a1), Paul Bingley (a1) (a5), Jacob Hjelmborg (a1) (a6), Qihua Tan (a1) (a2), Niels V. Holm (a1) (a7), James W. Vaupel (a1) (a8), Matt McGue (a1) (a9) and Kaare Christensen (a1) (a2) (a10)...

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