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The Chinese National Twin Registry: A Unique Data Source for Systems Epidemiology of Complex Disease

  • Tao Huang (a1), Wenjing Gao (a1), Jun Lv (a1), Canqing Yu (a1), Tao Wu (a1), Shengfeng Wang (a1), Chunxiao Liao (a1), Lu Meng (a1), Dongmeng Wang (a1), Zhaonian Wang (a1), Zengchang Pang (a2), Min Yu (a3), Hua Wang (a4), Xianping Wu (a5), Zhong Dong (a6), Fan Wu (a7), Guohong Jiang (a8), Xiaojie Wang (a9), Yu Liu (a10), Jian Deng (a11), Lin Lu (a12), Weihua Cao (a1) and Liming Li (a1)...

Abstract

The Chinese National Twin Registry (CNTR), initiated in 2001, has now become the largest twin registry in Asia. From 2015 to 2018, the CNTR continued to receive Chinese government funding and had recruited 61,566 twin-pairs by 2019 to study twins discordant for specific exposures such as environmental factors, and twins discordant for disease outcomes or measures of morbidity. Omic data, including genetics, genomics, metabolomics, and proteomics, and gut microbiome will be tested. The integration of omics and digital technologies in public health will advance our understanding of precision public health. This review introduces the updates of the CNTR, including study design, sample size, biobank, zygosity assessment, advances in research and future systems epidemiologic research.

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Author for correspondence: Liming Li, Email: lmlee@vip.163.com

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These authors contributed equally to this work.

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References

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Keywords

The Chinese National Twin Registry: A Unique Data Source for Systems Epidemiology of Complex Disease

  • Tao Huang (a1), Wenjing Gao (a1), Jun Lv (a1), Canqing Yu (a1), Tao Wu (a1), Shengfeng Wang (a1), Chunxiao Liao (a1), Lu Meng (a1), Dongmeng Wang (a1), Zhaonian Wang (a1), Zengchang Pang (a2), Min Yu (a3), Hua Wang (a4), Xianping Wu (a5), Zhong Dong (a6), Fan Wu (a7), Guohong Jiang (a8), Xiaojie Wang (a9), Yu Liu (a10), Jian Deng (a11), Lin Lu (a12), Weihua Cao (a1) and Liming Li (a1)...

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