Skip to main content Accessibility help
×
Home
Hostname: page-component-56f9d74cfd-hg4f7 Total loading time: 0.287 Render date: 2022-06-26T05:34:28.043Z Has data issue: true Feature Flags: { "shouldUseShareProductTool": true, "shouldUseHypothesis": true, "isUnsiloEnabled": true, "useRatesEcommerce": false, "useNewApi": true }

The Association Between Early Membrane Rupture, Latency, Clinical Chorioamnionitis, Neonatal Infection, and Adverse Perinatal Outcomes in Twin Pregnancies Complicated by Preterm Prelabour Rupture of Membranes

Published online by Cambridge University Press:  21 February 2012

Peter von Dadelszen*
Affiliation:
Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynaecology, University of British Columbia,Vancouver. pvd@cw.bc.ca
Sari Kives
Affiliation:
Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynaecology, University of British Columbia,Vancouver.
Marie-France Delisle
Affiliation:
Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynaecology, University of British Columbia,Vancouver.
R. Douglas Wilson
Affiliation:
Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynaecology, University of British Columbia,Vancouver.
Ruth Joy
Affiliation:
Clinical Research Support Unit, British Columbia Research Institute for Children's and Women's Health,Vancouver and Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynaecology, University of Toronto, Canada.
Laurie Ainsworth
Affiliation:
Clinical Research Support Unit, British Columbia Research Institute for Children's and Women's Health,Vancouver and Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynaecology, University of Toronto, Canada.
Lamya Al Kharusi
Affiliation:
Clinical Research Support Unit, British Columbia Research Institute for Children's and Women's Health,Vancouver and Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynaecology, University of Toronto, Canada.
Marilynne Oskamp
Affiliation:
Clinical Research Support Unit, British Columbia Research Institute for Children's and Women's Health,Vancouver and Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynaecology, University of Toronto, Canada.
Jon F.R. Barrett
Affiliation:
Clinical Research Support Unit, British Columbia Research Institute for Children's and Women's Health,Vancouver and Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynaecology, University of Toronto, Canada.
Greg Ryan
Affiliation:
Clinical Research Support Unit, British Columbia Research Institute for Children's and Women's Health,Vancouver and Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynaecology, University of Toronto, Canada.
Dan Farine
Affiliation:
Clinical Research Support Unit, British Columbia Research Institute for Children's and Women's Health,Vancouver and Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynaecology, University of Toronto, Canada.
P. Gareth R. Seaward
Affiliation:
Clinical Research Support Unit, British Columbia Research Institute for Children's and Women's Health,Vancouver and Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynaecology, University of Toronto, Canada.
*
*Address for correspondence: Dr Peter von Dadelszen, Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynaecology, Children's and Women's Health Centre of British Columbia, Suite 2H30, 4500 Oak Street, Vancouver, British Columbia, Canada V6H 3N1.

Abstract

HTML view is not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

The objective of this study was to evaluate associations between adverse outcomes in twin pregnancies and preterm prelabour rupture of membranes (PPROM). A chart review of 246 consecutive twin pregnancies with confirmed PPROM was conducted. Regression analysis (β [natural log of the odds ratio] and odds ratio [OR]) was performed to identify independent predictors. Two hundred and forty-six twin pregnancies, 492 liveborns, and 20 neonatal deaths. Mean (SD) PPROM gestational age (GA): 31.3 (3.8) wk; delivery GA: 32.0 (3.3) wk. PPROM < 30wk was associated with increased parity (OR: 2.66), and log (admission leukocyte count) (OR: 9.99). Shortened latency was associated with PPROM GA (β = −0.17) and chorioamnionitis (β = 0.95). Neonatal sepsis was predicted by lower delivery GA (OR: 2.04). Adverse perinatal outcomes were protected against by older GA at PPROM (OR 0.53) and shortened latency (OR 0.73). It was concluded that increased leukocytosis and parity implies an infectious aetiology in earlier PPROM. Increased risk for neonatal sepsis at earlier delivery GA is consistent with gestation-dependent fetal immunocompetence. Early PPROM and long latencies were associated with increased adverse perinatal outcomes.

Type
Articles
Copyright
Copyright © Cambridge University Press 2003
You have Access

Save article to Kindle

To save this article to your Kindle, first ensure coreplatform@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

The Association Between Early Membrane Rupture, Latency, Clinical Chorioamnionitis, Neonatal Infection, and Adverse Perinatal Outcomes in Twin Pregnancies Complicated by Preterm Prelabour Rupture of Membranes
Available formats
×

Save article to Dropbox

To save this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you used this feature, you will be asked to authorise Cambridge Core to connect with your Dropbox account. Find out more about saving content to Dropbox.

The Association Between Early Membrane Rupture, Latency, Clinical Chorioamnionitis, Neonatal Infection, and Adverse Perinatal Outcomes in Twin Pregnancies Complicated by Preterm Prelabour Rupture of Membranes
Available formats
×

Save article to Google Drive

To save this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you used this feature, you will be asked to authorise Cambridge Core to connect with your Google Drive account. Find out more about saving content to Google Drive.

The Association Between Early Membrane Rupture, Latency, Clinical Chorioamnionitis, Neonatal Infection, and Adverse Perinatal Outcomes in Twin Pregnancies Complicated by Preterm Prelabour Rupture of Membranes
Available formats
×
×

Reply to: Submit a response

Please enter your response.

Your details

Please enter a valid email address.

Conflicting interests

Do you have any conflicting interests? *