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Development of a linear transient model for stimulation of isolated cardiac cells*

Published online by Cambridge University Press:  15 December 2000

P. Pham ,
G. Cauffet ,
A. Bardou ,
J. Olivares  and
E. Novakov
P. Pham*
Affiliation:
Laboratoire d'Instrumentation Micro-Informatique et d'Electronique, LIME/UJFG, BP 53X, 38041 Grenoble, France
G. Cauffet
Affiliation:
Laboratoire d'Instrumentation Micro-Informatique et d'Electronique, LIME/UJFG, BP 53X, 38041 Grenoble, France
A. Bardou
Affiliation:
INSERM - Cardiologie Théorique - CHU Pitié Salpétrière, 91 boulevard de l'Hôpital, 75634 Paris Cedex 13, France
J. Olivares
Affiliation:
LBFA/UJFG, BP 53, 38041 Grenoble Cedex 9, France
E. Novakov
Affiliation:
Laboratoire d'Instrumentation Micro-Informatique et d'Electronique, LIME/UJFG, BP 53X, 38041 Grenoble, France
*
pascale.pham@cea.frcauffet@leg.ensieg.inpg.fr
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Abstract

Isolated cardiac cells stimulators design can be aided by numerical tools based on the behavior model. The linear model (RC circuit) is the most straightforward model for describing the electrical membrane cell behavior for an external electrical stimulation: however, an adjustment is necessary to make it competent to describe correctly the different types of excitation variability experimentally observed. A Linear Transient Model is presented, solved by the Finite Element Method.

Keywords

Type
Research Article
Information
The European Physical Journal - Applied Physics , Volume 12 , Issue 3 , December 2000 , pp. 217 - 222
Copyright
© EDP Sciences, 2000

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Footnotes

*

This paper has been presented at NUMELEC 2000.

References

M.R. Mulligan, R.J. O'Neill, P.C. Zei, L. Tung, Graded effects of pulsed electric fields on contractility of single heart cells, 10th Annual International Conference of IEEE Engineering in Medecine & Biology Society, 1988.
Bardou, A.L., Chesnais, J.M., Birkui, P.J., Govaere, M.C., Auger, P.M., Von Euw, D., Degonde, J., PACE 13, 1590 (1990). CrossRef
Barr, R.C., Plonsey, R., IEEE Trans. Biol. Eng. 42, 1185 (1995). CrossRef
J. Cronin, Mathematical aspects of Hodgkin-Huxley neural theory (Cambridge University Press, 1987), ISBN 0-521-33482-9.
V. Poulbot, Contribution à l'étude des champs électriques très basses fréquences en milieux océaniques, Thèse de l'école Centrale de Lyon, France, 1993.
Ranjan, R., Takhor, N.V., Ann. Biomed. Eng. 23, 812 (1995). CrossRef
Rogers, J.M., McCulloch, A.D., IEEE Trans. Biomed. Eng. 41, 734 (1994). CrossRef