Skip to main content Accessibility help
×
×
Home

Viloxazine in the Treatment of Depressive Neurosis: A Controlled Clinical Study with Doxepin and Placebo

  • Joseph P. McEvoy (a1), William F. Sheridan (a1), W. R. C. Stewart (a1), Thomas A. Ban (a1), William H. Wilson (a1), William Guy (a1) and J. David Schaffer (a1)...

Summary

In a four-week, double-blind, clinical trial thirty-one patients with depressive neurosis were treated with viloxazine, doxepin, or placebo. There were no differences among the three groups in therapeutic effects. Many depressed out-patients improve on placebo. Viloxazine hydrochloride is one of a series of compounds developed to explore the central nervous system activity of the aryloxypropanolamine type of β-adreno-receptor antagonists. Initial clinical studies support the hypothesis that viloxazine has antidepressant properties in man (Bayliss et al, 1974; Bereen, 1973; Pichot et al, 1975; Tsegos and Ekdawi, 1974).

Copyright

References

Hide All
Amsterdam, J., Brunswick, D. & Mendels, J. (1980) The clinical application of tricyclic antidepressant pharmacokinetics and plasma levels. American Journal of Psychiatry, 137, 653–62.
Bayliss, P. F. C., Dewsbury, A. R., Donald, J. F., Harcup, J. W., Mayer, M., Million, R., Molla, A. L., Murphy, J. E., Plant, B. & Shaoul, E. (1974) A double-blind controlled trial of ‘vivalan’ (viloxazine hydrochloride) and imipramine hydrochloride in the treatment of depression in general practice. Journal of International Medical Research, 2 (4), 260–4.
Bereen, F. J. (1973) A new potential antidepressive. Lancet, i, 379–80.
Kiloh, L. G. & Garside, R. F. (1963) The independence of neurotic depression and endogenous depression. British Journal of Psychiatry, 109, 451–63.
Lasagna, L. (1971) Decision processes in establishing the efficacy and safety of psychoactive agents. In Principles and Problems in Establishing the Efficacy of Psychotropic Agents (eds. J. Levine, B. C. Schiele, and L. Bouthilet). Public Health Service Publication No. 2138.
Overall, J. E., Hollister, L. E., Pokorny, A. D., Casey, J. F. & Katz, G. (1962) Drug therapy in depressions. Controlled evaluation of imipramine, isocarboxazid, dextroamphetamine, amobarbital, and placebo. Clinical Pharmacology and Therapeutics, 3, 16.
Pichot, P., Guelfi, J. & Dreyfus, J. F. (1975) A controlled multicentre therapeutic trial of viloxazine (vivalan). Journal of International Medical Research, 3, Suppl 3, 80–6, 100.
Tsegos, I. K. & Ekdawi, M. Y. (1974) Double-blind controlled comparison of imipramine and viloxazine in depression. Current Medical Research and Opinion, 2, 455–60.
Uhlenhuth, E. G. & Park, L. C. (1964) The influence of medication (imipramine) and doctor in relieving depressed psychoneurotic outpatients. Journal of Psychiatric Research, 2, 101–22.
Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

The British Journal of Psychiatry
  • ISSN: 0007-1250
  • EISSN: 1472-1465
  • URL: /core/journals/the-british-journal-of-psychiatry
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Metrics

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed

Viloxazine in the Treatment of Depressive Neurosis: A Controlled Clinical Study with Doxepin and Placebo

  • Joseph P. McEvoy (a1), William F. Sheridan (a1), W. R. C. Stewart (a1), Thomas A. Ban (a1), William H. Wilson (a1), William Guy (a1) and J. David Schaffer (a1)...
Submit a response

eLetters

No eLetters have been published for this article.

×

Reply to: Submit a response


Your details


Conflicting interests

Do you have any conflicting interests? *