Baldessarini, R, Henk, H, Sklar, A, Chang, J, Leahy, L. Psychotropic medications for patients with bipolar
disorder in the United States: polytherapy and adherence.
2008; 59: 1175–83.
Pope, HG Jr, McElroy, SL, Keck, PE Jr, Hudson, JI. Valproate in the treatment of acute mania. A
placebo-controlled study. Arch Gen
1991; 48: 62–8.
Bowden, CL, Brugger, AM, Swann, AC, Calabrese, JR, Janicak, PG, Petty, F, et al. Efficacy of divalproex vs lithium and placebo
in the treatment of mania. The Depakote Mania Study
1994; 271: 918–24.
Bowden, CL, Swann, AC, Calabrese, JR, Rubenfaer, LM, Wozniak, PJ, Collins, MA, et al. A randomized, placebo-controlled, multicenter
study of divalproex sodium extended release in the treatment of acute
mania. J Clin Psychiatry
2006; 67: 1501–10.
Bowden, C, Gogus, A, Grunze, H, Haggstrom, L, Rybakowski, J, Vieta, E. A 12-week, open, randomized trial comparing sodium
valproate to lithium in patients with bipolar I disorder suffering from a
manic episode. Int Clin Psychopharmacol
2008; 23: 254–62.
Freeman, TW, Clothier, JL, Pazzaglia, P, Lesem, MD, Swann, AC. A double-blind comparison of valproate and lithium
in the treatment of acute mania. Am J
1992; 149: 108–11.
Macritchie, K, Geddes, JR, Scott, J, Haslam, D, de, LM, Goodwin, G. Valproate for acute mood episodes in bipolar
disorder. Cochrane Database Syst Rev
Grunze, H, Vieta, E, Goodwin, GM, Bowden, C, Licht, RW, Möller, HJ, et al. The World Federation of Societies of
Biological Psychiatry (WFSBP) Guidelines for the Biological Treatment of
Bipolar Disorders: Update 2010 on the treatment of acute bipolar
depression. World J Biol Psychiatry
Bowden, CL, Calabrese, JR, McElroy, SL, Gyulai, L, Wassef, A, Petty, F, et al. A randomized, placebo-controlled 12-month
trial of divalproex and lithium in treatment of outpatients with bipolar
I disorder. Divalproex Maintenance Study Group.
Arch Gen Psychiatry
2000; 57: 481–9.
Geddes, JR, Goodwin, GM, Rendell, J, Azorin, JM, Cipriani, A, Ostacher, MJ, et al. Lithium plus valproate combination therapy
versus monotherapy for relapse prevention in bipolar I disorder
(BALANCE): a randomised open-label trial.
2010; 375: 385–95.
Lauer, MS, Collins, FS. Using science to improve the nation's health system:
NIH's commitment to comparative effectiveness research.
2010; 303: 2182–3.
Baldessarini, RJ. Treatment research in bipolar disorder: issues and
recommendations. CNS Drugs
2002; 16: 721–9.
Calabrese, JR, Kemp, DE. Bipolar drug development: are we getting closer to
the real world?
Am J Psychiatry
2008; 165: 1234–6.
Citrome, L. Interpreting and applying the CATIE results: with
CATIE, context is key when sorting out Phases 1, 1A, 1B, 2E, and
2007; 4: 23–9.
Licht, RW. Limitations in randomised controlled trials
evaluating drug effects in mania. Eur Arch
Psychiatry Clin Neurosci
2001; 251 (suppl 2):
Reed, C, Novick, D, Gonzalez-Pinto, A, Bertsch, J, Haro, JM. Observational study designs for bipolar disorder –
what can they tell us about treatment in acute mania?
Prog Neuropsychopharmacol Biol Psychiatry
2009; 33: 715–21.
Malig, C. The Civil Registration System in Denmark. (IIVRS Technical
Paper no. 66). International Institute for Vital
Registration and Statistics,
Munk-Jorgensen, P, Mortensen, PB. The Danish Psychiatric Central
Register. Dan Med Bull
1997; 44: 82–4.
Juel, K, Helweg-Larsen, K. The Danish registers of causes of
death. Dan Med Bull
1999; 46: 354–7.
Andersen, TF, Madsen, M, Jorgensen, J, Mellemkjaer, L, Olsen, JH. The Danish National Hospital Register. A valuable
source of data for modern health sciences. Dan
1999; 46: 263–8.
World Health Organization. Klassifikation af
Sygdomme. Systematisk Del. [International Statistical Classification of
Diseases and Health Related Problems (10th revision, Danish
edn)]. Munksgaard, Copenhagen,
WHO Collaborating Centre for Drug Statistics Methodology.
ATC index with DDDs. WHO Collaborating
Centre for Drug Statistics Methodology,
Kessing, LV, Sondergard, L, Kvist, K, Andersen, PK. Suicide risk in patients treated with
lithium. Arch Gen Psychiatry
2005; 62: 860–6.
Müller-Oerlinghausen, B, Berghofer, A, Ahrens, B. The antisuicidal and mortality-reducing effect of
lithium prophylaxis: consequences for guidelines in clinical
psychiatry. Can J Psychiatry
2003; 48: 433–9.
Schou, M. Lithium treatment at 52. J
Schou, M. Suicidal behavior and prophylactic lithium treatment
of major mood disorders: a review of reviews.
Suicide Life Threat Behav
2000; 30: 289–93.
Licht, RW, Vestergaard, P, Kessing, LV, Larsen, JK, Thomsen, PH. Psychopharmacological treatment with lithium and
antiepileptic drugs: suggested guidelines from the Danish Psychiatric
Association and the Child and Adolescent Psychiatric Association in
Denmark. Acta Psychiatr Scand Suppl
Goodwin, GM, Geddes, JR. Latest maintenance data on lithium in bipolar
disorder. Eur Neuropsychopharmacol
2003; 13 (suppl 2):
Coryell, W. Maintenance treatment in bipolar disorder: a
reassessment of lithium as the first choice.
2009; 11 (suppl 2):
Grunze, H, Vieta, E, Goodwin, GM, Bowden, C, Licht, RW, Moller, HJ, et al. The World Federation of Societies of
Biological Psychiatry (WFSBP) guidelines for the biological treatment of
bipolar disorders: update 2009 on the treatment of acute
mania. World J Biol Psychiatry
Partonen, T, Sihvo, S, Lonnqvist, JK. Patients excluded from an antidepressant efficacy
trial. J Clin Psychiatry
1996; 57: 572–5.
Keitner, GI, Posternak, MA, Ryan, CE. How many subjects with major depressive disorder
meet eligibility requirements of an antidepressant efficacy
J Clin Psychiatry
2003; 64: 1091–3.
Zimmerman, M, Mattia, JI, Posternak, MA. Are subjects in pharmacological treatment trials of
depression representative of patients in routine clinical
Am J Psychiatry
2002; 159: 469–73.
Kleindienst, N, Severus, WE, Moller, HJ, Greil, W. Is polarity of recurrence related to serum lithium
level in patients with bipolar disorder?
Eur Arch Psychiatry Clin Neurosci
2005; 255: 72–4.
Licht, RW. A new BALANCE in bipolar I disorder.
2010; 375: 350–2.
Cipriani, A, Pretty, H, Hawton, K, Geddes, JR. Lithium in the prevention of suicidal behavior and
all-cause mortality in patients with mood disorders: a systematic review
of randomized trials. Am J Psychiatry
2005; 162: 1805–19.
Goodwin, FK, Fireman, B, Simon, GE, Hunkeler, EM, Lee, J, Revicki, D. Suicide risk in bipolar disorder during treatment
with lithium and divalproex. JAMA
2003; 290: 1467–73.
Sondergard, L, Lopez, AG, Andersen, PK, Kessing, LV. Mood-stabilizing pharmacological treatment in
bipolar disorders and risk of suicide. Bipolar