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Treatment of Acute Mental Disorders with an Adrenal Steroid

Published online by Cambridge University Press:  29 January 2018

Armand W. Loranger
Armand W. Loranger*
Affiliation:
Cornell University Medical College, and Head of Clinical Psychology, New York Hospital—Cornell Medical Center, Department of Psychiatry, Westchester Division, White Plains, New York 10605
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Extract

In this journal, Hardwick, Pearse and Petrow (1957) advanced the view that slightly lowered steroidal production may predispose individuals to abnormal mental states, thus suggesting the possibility of treating such disorders with some form of replacement therapy. They screened a number of steroidal compounds for such use and concluded that the most promising was 6β hydroxy:3: 5 cyclopregnan 20-one (“neurosterone”). In their small-scale preliminary study this agent appeared to be of value in the treatment of a variety of psychiatric patients, including those with symptoms of anxiety, depression, and obsessive behaviour.

Type
Abstract
Information
The British Journal of Psychiatry , Volume 114 , Issue 512 , July 1968 , pp. 843 - 844
Copyright
Copyright © Royal College of Psychiatrists, 1968 

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References

Hardwick, S. W., Pearse, J. J., and Petrow, V. (1957). “6β-hydroxy-3: 5-cyclopregnan-20-one in mental states.” J. ment. Sci., 103, 835–839.CrossRefGoogle Scholar
Rubin, G. T., and Mandell, A. J. (1966). “Adrenal cortical activity in pathological emotional states: A review” Amer. J. Psychiat., 123, 387–400.Google Scholar
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