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Transient Recurrence of Auditory Hallucinations During Acute Dystonia

  • Leo P. W. Chiu (a1)


Three schizophrenic patients who had transient recurrence of auditory hallucinations during acute dystonia precipitated by neuroleptic medication are reported. If it is accepted that psychotic symptoms result from dopaminergic overactivity, such phenomena suggest that acute dystonia might also have been caused by increased dopaminergic neurotransmission in these cases.



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Angrist, B. & Sudilovsky, A. (1978) Central nervous system stimulants: historical aspects and clinical effects. In Handbook of Psychopharmacology (eds Iverson L. L., Iverson S. D. & Snyder S. H.), vol. 11, pp. 99165. New York: Plenum Press.
Borison, R. L., Blowers, A. J. & Diamond, B. I. (1982) New horizons in the treatment of neuropsychiatric disorders. In Tardive Dyskinesia and Related Involuntary Movement Disorders (ed. De Veaugh-Geiss J.), pp. 131146. Boston: John Wright.
Bowers, M. B. Jr (1973) 5-Hydroxyindoleacetic acid (5HIAA) and homovanillic acid (HVA) following probenecid in acute psychotic patients treated with phenothiazines. Psychopharmacologia, 28, 309318.
Connell, P. H. (1958) Amphetamine Psychosis (Maudsley monographs). London: Oxford University Press.
Cooklin, R., Sturgeon, D. & Leff, J. (1983) The relationship between auditory hallucinations and spontaneous fluctuations of skin conductance in schizophrenia. British Journal of Psychiatry, 142, 4752.
Crow, T. J. (1987) The dopamine hypothesis survives, but there must be a way ahead. British Journal of Psychiatry, 151, 460465.
Dinan, T. G. (1987) Calcium-activated potassium conductance: an alternative to the dopamine hypothesis of neuroleptic action? British Journal of Psychiatry, 151, 455459.
Fahn, S. & Marsden, C. D. (1987) The treatment of dystonia. In Movement Disorders 2 (eds Marsden C. D. & Fahn S.), pp. 359382. London: Butterworths.
Fann, W. E. (1966) Use of methylphenidate to counteract acute dystonic effects of phenothiazines. American Journal of Psychiatry, 122, 12931294.
Fyro, B., Wode-Helgodt, B., Borg, S., et al (1974) The effect of chlorpromazine on homovanillic acid levels in cerebrospinal fluid of schizophrenic patients. Psychopharmacologia, 35, 287294.
Garver, D. L., Davis, J. M., Dekirmejian, H., et al (1976) Pharmacokinetics of red blood cell phenothiazine and clinical effects: acute dystonic reactions. Archives of General Psychiatry, 33, 862.
Grohmann, R., Gunther, W. & Ruther, E. (1983) Adverse effects of psychotropic drugs. In Psychopharmacology 1. Part 2: Clinical Psychopharmacology (eds Hippius H. & Winokur G.), pp. 378397. Amsterdam: Excerpta Medica.
Harris, P. Q., Brown, S. J., Friedman, M. J., et al (1984) Plasma drug and homovanillic acid levels in psychotic patients receiving neuroleptics. Biological Psychiatry, 19, 849860.
Hirsch, S. R. (1982) Medication and physical treatment of schizophrenia. In Handbook of Psychiatry, vol. 3. Psychoses of Uncertain Aetiology (eds Wing J. K. & Wing L.), pp. 7487. Cambridge: Cambridge University Press.
Hollister, L. E. (1983) Clinical Pharmacology of Psychotherapeutic Drugs (2nd edn), pp. 110171. New York: Churchill Livingstone.
Iversen, L. L. (1987) Commentary on Dinan's hypothesis. British Journal of Psychiatry, 151, 459460.
Korczyn, A. D. & Goldberg, G. J. (1972) Intravenous diazepam in drug-induced dystonic reactions. British Journal of Psychiatry, 121, 7577.
Loudon, J. B. (1983) Drug treatments. In Companion to Psychiatric Studies (3rd edn) (eds Kendell R. E. & Zealley A. K.), pp. 603627. Edinburgh: Churchill Livingstone.
Mackay, A. V. P. (1982) Antischizophrenic drugs. In Drugs in Psychiatric Practice (ed. Tyrer P. J.), pp. 4281. London: Butterworths.
Randrup, A. & Munkvad, I. (1972) Evidence indicating an association between schizophrenia and dopaminergic hyperactivity in the brain. Orthomolecular Psychiatry, 1, 27.
Roos, R. A. C. & Bruyn, G. W. (1986) Symptomatic dystonias. In Handbook of Clinical Neurology, vol. 5 (49): Extrapyramidal Disorders (eds Vinken P. J., Bruyn G. W. & Klawans H. L.), pp. 541547. Amsterdam: Elsevier Science Publishers.
Roos, R. A. C. & Buruma, O. J. S. (1984) Extrapyramidal side effects of neuroleptic drugs. Journal of Drug Therapy and Research, 9, 8285.
Sedvall, G., Fyro, B., Nyback, H., et al (1974) Mass fragmentometric determination of homovanillic acid in lumbar cerebrospinal fluid of schizophrenic patients during treatment with antipsychotic drugs. Journal of Psychiatric Research, 11, 7580.
Silverstone, T. & Goodall, E. (1985) How amphetamine works. In Psychopharmacology: Recent Advances and Future Prospects (ed. Iverson S. D.), pp. 315325. Oxford: Oxford University Press.
Silverstone, T. & Turner, P. (1982) Drug Treatment in Psychiatry, pp. 93133. London: Routledge & Kegan Paul.
Slade, P. D. (1972) The effects of systemic desensitisation on auditory hallucinations. Behaviour Research and Therapy, 10, 8591.
Smith, M. J. & Miller, M. M. (1961) Severe extrapyramidal reactions to perphenazine treated with diphenhydramine. New England Journal of Medicine, 264, 396397.
Swett, C. (1975) Drug-induced dystonia. American Journal of Psychiatry, 132, 532534.
Walker, J. I. & Cavenar, J. O. Jr (1983) Hallucinations. In Signs and Symptoms in Psychiatry (eds Cavenar J. O. Jr & Brodie H. K. H.), pp. 433454. Philadelphia: Lippincott.

Transient Recurrence of Auditory Hallucinations During Acute Dystonia

  • Leo P. W. Chiu (a1)


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Transient Recurrence of Auditory Hallucinations During Acute Dystonia

  • Leo P. W. Chiu (a1)
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