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Thyroid-Induced Mania in Hypothyroid Patients

Published online by Cambridge University Press:  29 January 2018

Allan M. Josephson  and
Thomas B. Mackenzie
Allan M. Josephson
Affiliation:
Department of Psychiatry, Box 393
Thomas B. Mackenzie
Affiliation:
Departments of Psychiatry and Medicine, Box 324 University of Minnesota Medical School, Mayo Medical Building, Minneapolis, Minnesota, USA 55455
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Summary

This retrospective study, based on 18 case reports, describes an organic affective syndrome, manic type, occurring shortly after the initiation of thyroid replacement in hypothyroid patients. The symptomatology and homogeneity of the syndrome offers insight into the relationship between thyroid activity and affective disturbance. The patients experiencing mania showed concurrent psychopathology at the time of replacement therapy, frequently had a past history of personal or familial psychiatric disorder and were given dosages in the high range of normal. The potential morbidity of the manic state was considerable. These findings suggest that a group of hypothyroid patients at risk can be identified. In such a group, lower initial dosages and gradual increases in dosage may be indicated.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 137 , Issue 3 , September 1980 , pp. 222 - 228
Copyright
Copyright © Royal College of Psychiatrists, 1980 

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References

Akelaitis, A. J. E. (1936) Psychiatric aspects of myxoedema. Journal of Nervous and Mental Diseases, 83, 22–36.CrossRefGoogle Scholar
Akiskal, H. S. & McKinney, W. T. Jr. (1975) Overview of recent research in depression. Archives of General Psychiatry, 32, 285–305.CrossRefGoogle ScholarPubMed
Asher, R. (1949) Myxoedematous madness. British Medical Journal, ii, 255–62.CrossRefGoogle ScholarPubMed
Astwood, E. G. (1975) Thyroid and antithyroid drugs. In The Pharmacological Basis of Therapeutics (5th ed.) (ed. L. S. Goodman and A. Gilman). New York: The Macmillan Company.Google Scholar
Browning, T. S., Atkins, R. W. & Weiner, H. (1954) Cerebral metabolic disturbances in hypothyroidism. Archives of Internal Medicine, 93, 938–50.Google ScholarPubMed
Bunney, W. E., Goodwin, F. K. & Murphy, D. L. (1972) The ‘switch process' in manic depressive illness. Archives of General Psychiatry, 27, 312–7.Google ScholarPubMed
Calvert, R. J., Smith, E. & Andrews, L. G. (1954) Coexistent myxoedema heart disease and psychosis. British Medical Journal, ii, 891–4.CrossRefGoogle ScholarPubMed
Checkley, S. A. (1978) Thyrotoxicosis and the course of manic-depressive illness. British Journal of Psychiatry, 133, 219–23.CrossRefGoogle ScholarPubMed
Cobb, W. E. & Jackson, I. M. D. (1978) Drug therapy reviews: Management of hypothyroidism. American Journal of Hospital Pharmacy, 35, 51–8.Google ScholarPubMed
Diagnostic & Statistical Manual of Mental Disorders, Third Edition (1978) The Task Force on Nomenclature and Statistics of the American Psychiatric Association, R. L. Spitzer, Chairman, American Psychiatric Association, Washington.Google Scholar
Easson, W. M. (1966) Myxedema with psychosis. Archives of General Psychiatry, 14, 277–83.CrossRefGoogle ScholarPubMed
Jain, V. K. (1972) A psychiatric study of hypothyroidism. Psychiatric Clinica, 5, 121–30.Google ScholarPubMed
Jellinek, E. H. (1962) Fits, faints, coma and dementia in myxoedema. Lancet, ii, 1010–12.CrossRefGoogle ScholarPubMed
Josephson, A. M. & Mackenzie, T. B. (1979) Appearance of manic psychosis following rapid normalization of thyroid status. American Journal of Psychiatry, 136, 846–7.Google ScholarPubMed
Karnosh, L. J. & Stout, R. E. (1935) Psychoses of myxedema. American Journal of Psychiatry, 91, 1203–72.CrossRefGoogle Scholar
Kerlinger, F. N. (1973) Foundations of Behavioral Research. New York: Holt, Rinehart and Winston Inc.Google Scholar
Klawans, H. L., Goetz, C. & Weiner, W. J. (1974) Dopamine receptor site sensitivity in hypothyroid and hypothyroid guinea pigs. In Advances in Neurology, vol. 5. New York: Raven Press.Google Scholar
Lidz, T. (1971) Hypothyroidism: emotions and mentation. In The Thyroid (eds. S. C. Werner and S. H. Ingbar). New York: Harper and Row.Google Scholar
Means, J. H. (1948) Thyroid and Its Diseases, p. 276. Philadelphia: J. B. Lippincott.Google ScholarPubMed
Olivarius, B. de F. & Röder, E. (1970) Reversible psychosis and dementia in myxedema. Acta Psychiatrica Scandinavica, 46, 1–13.CrossRefGoogle Scholar
Prange, A. J. (1969) Enhancement of imipramine antidepressant activity by thyroid hormone. American Journal of Psychiatry, 126, 457–69.CrossRefGoogle ScholarPubMed
Refetoff, S. (1975) Thyroid hormone therapy. Medical Clinics of North America, 59, 1147–62.CrossRefGoogle ScholarPubMed
Ridgway, E. C., Maloof, F. & Federman, D. D. (1976) Rational therapy in hypothyroidism. Rational Drug Therapy, 10, 1–7.Google ScholarPubMed
Stolk, J. M. & Whybrow, P. C. (1975) Clinical and experimental inter-relationships between sympathetic nervous system activity and pituitary-thyroid function. In Symposium of the International Society of Psychoneuroendocrinology, Visegrad, 1975. Proceedings of the Akademiai Kiado, Budapest, Hungarian Academy of Sciences.Google Scholar
Ziegler, L. H. (1931) Psychosis associated with myxoedema. Journal of Neurology and Psychopathology, 11, 20–7.Google Scholar
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