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Suicidal behaviour and mortality in first-episode psychosis: the OPUS trial

  • Mette Bertelsen (a1), Pia Jeppesen (a1), Lone Petersen (a1), Anne Thorup (a1), Johan ⊘hlenschlæger (a1), Phuong Le Quach (a1), Torben Østergaard Christensen (a1), Gertrud Krarup (a1), Per J⊘rgensen (a2) and Merete Nordentoft (a1)...

Abstract

Background

Those with first-episode psychosis are at high-risk of suicide

Aims

To identify predictive factors for suicidal thoughts, plans and attempts, and to investigate the rate of suicides and other deaths during the 5 years after first diagnosis and initiation of treatment

Method

A longitudinal, prospective, 5-year follow-up study of 547 individuals with first-episode schizophrenia spectrum psychosis. Individuals presenting for their first treatment in mental health services in two circumscribed urban areas in Denmark were included in a randomised controlled trial of integrated v. standard treatment. All participants were followed in the Danish Cause of Death Register for 5 years. Suicidal behaviour and clinical and social status were assessed using validated interviews and rating scales at entry, and at 1- and 2-year follow-ups

Results

Sixteen participants died during the follow-up. We found a strong association between suicidal thoughts, plans and previous attempts, depressive and psychotic symptoms and young age, and with suicidal plans and attempts at 1- and 2-year follow-up

Conclusions

In this first-episode cohort depressive and psychotic symptoms, especially hallucinations, predicted suicidal plans and attempts, and persistent suicidal behaviour and ideation were associated with high risk of attempted suicide

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Copyright

Corresponding author

Merete Nordentoft, Bispebjerg Hospital, Department of Psychiatry, Bispebjerg Bakke 23, 2400 Copenhagen NV, Denmark. Tel: +4535316239, fax +4535313953, email: merete.nordentoft@dadlnet.dk

Footnotes

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Declaration of interest

None.

Footnotes

References

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The British Journal of Psychiatry
  • ISSN: 0007-1250
  • EISSN: 1472-1465
  • URL: /core/journals/the-british-journal-of-psychiatry
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Suicidal behaviour and mortality in first-episode psychosis: the OPUS trial

  • Mette Bertelsen (a1), Pia Jeppesen (a1), Lone Petersen (a1), Anne Thorup (a1), Johan ⊘hlenschlæger (a1), Phuong Le Quach (a1), Torben Østergaard Christensen (a1), Gertrud Krarup (a1), Per J⊘rgensen (a2) and Merete Nordentoft (a1)...
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