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Stereotactic Limbic Leucotomy: Neurophysiological Aspects and Operative Technique

  • Desmond Kelly (a1), Alan Richardson (a1) and Nita Mitchell-Heggs (a1)

Extract

Psychosurgery has always been, and is likely to remain, a controversial subject. Blind operations lack precision and can lead to adverse personality changes or other serious side-effects. Open surgery is becoming less acceptable because of the difficulties of accurately assessing the extent of a lesion and its exact location. The introduction of stereotactic techniques enables far smaller lesions to be placed with a high degree of accuracy, and increased knowledge of the limbic system has contributed to advances in this field.

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Abrahams, V. C., Hilton, S. M., and Zbrozyna, A. (1960). ‘Active muscle vasodilatation produced by stimulation of the brain stem: its significance in the defence reaction.Journal of Physiology (London), 154, 491513.
Balasubramaniam, V., and Ramamurthi, B. (1968). ‘Stereotaxic amygdalotomy.Proceedings of the Australian Association of Neurologists, 5, 277–8.
Ballantine, H. T., Cassidy, W. L., Flanagan, N. B., and Marino, R. (1967). ‘Stereotaxic anterior cingulotomy for neuropsychiatric illness and intractable pain.Journal of Neurosurgery, 26, 488–95.
Barcroft, H., Brod, J., Hejl, Z., Hirsjarvi, E. A., and Kitchin, A. H. (1960). ‘The mechanism of the vasodilatation in the forearm muscle during stress (mental arithmetic).Clinical Science, 19, 577–86.
Clark, W. E. Le G. (1948). ‘The connexions of the frontal lobes of the brain.Lancet, i, 353–6.
Glees, P., Cole, J., Whitty, C. W. M., and Cairns, H. (1950). ‘The effects of lesions in the cingular gyrus and adjacent areas in monkeys.Journal of Neurology, Neurosurgery and Psychiatry, 13, 178–90.
Heath, R. G., and Mickle, W. A. (1960). ‘Evaluation of seven years experience with depth electrode studies in human patients’, in Electrical Studies on the Unanesthetized Brain (ed. Ramey, and O'Doherty, ). New York.
Hilton, S. M., and Zbrozyna, A. W. (1963). ‘Amygdaloid region for defence reactions and its efferent pathway to the brain stem.Journal of Physiology (London), 165, 160–73.
Hunter Brown, M., and Lighthill, J. A. (1968). ‘Selective anterior cingulotomy: a psychosurgical evaluation.Journal of Neurosurgery, 29, 513–19.
Jackson, H. (1954). ‘Leucotomy—a recent development.Journal of Mental Science, 100, 62–5.
Kelly, D. H. W. (1966). ‘Measurement of anxiety by forearm blood flow.British Journal of Psychiatry, 112, 789–98.
Kelly, D. H. W. (1972). ‘Physiological changes during operations on the limbic system in man.Conditional Reflex. 7, 127–38.
Kelly, D. H. W., Mitchell-Heggs, N., and Sherman, D. (1971). ‘Anxiety and the effects of sodium lactate assessed clinically and physiologically.British Journal of Psychiatry, 119, 129–41.
Kelly, D. H. W., Richardson, A., Mitchell-Heggs, N., Greenup, J., Chen, C., and Hafner, R. J. (1973). ‘Stereotactic limbic leucotomy: a preliminary report on 40 patients.British Journal of Psychiatry, 122, 141–8.
Kelly, D. H. W., Walter, C. J. S., and Sargant, W. (1966). ‘Modified leucotomy assessed by forearm blood flow and other measurements.British Journal of Psychiatry, 112, 871–81.
Kelly, D. H. W., Walter, C. J. S., Mitchell-Heggs, N., and Sargant, W. (1972). ‘Modified leucotomy assessed clinically, physiologically and psychologically at six weeks and eighteen months.British Journal of Psychiatry, 120, 1929.
Knight, G. C. (1969). ‘Stereotactic surgery for the relief of suicidal and severe depression and intractable psychoneurosis.Postgraduate Medical Journal, 45, 113.
Knight, G. C. and Tredgold, R. F. (1955). ‘Orbital leucotomy— a review of 52 cases.Lancet, i, 981–5.
Lewin, W. (1961). ‘Observations on selective leucotomy.Journal of Neurology, Neurosurgery and Psychiatry, 24, 3744.
Livingston, K. E. (1953). ‘Cingulate cortex isolation for the treatment of psychoses and psychoneuroses.Research Publications of the Association for Research in Nervous and Mental Disease, 31, 374–8.
Livingston, K. E. (1969). ‘The frontal lobes revisited.Archives of Neurology, 20, 90–5.
Livingston, R. B., Fulton, J. F., Delgado, J. M. R., Sachs, E., Brendeer, S. J., and Davis, G. D. (1948). ‘Stimulation and regional ablation of orbital surface of frontal lobe.Research Publications of the Association for Research in Nervous and Mental Disease, 27, 405–20.
MacLean, P. D. (1958). ‘Contrasting functions of limbic and neocortical systems of the brain and their relevance to psychophysiological aspects of medicine.American Journal of Medicine, 25, 611–26.
MacLean, P. D. (1970). ‘The triune brain, emotion and scientific bias’, in The Neurosciences: Second Study Program (ed. F. O. Schmitt), pp. 336–49. New York.
MacLean, P. D. and Delgado, J. M. R. (1953). ‘Electrical and chemical stimulation of fronto-temporal portion of limbic system in the waking animal.Electroencephalography and Clinical Neurophysiology, 5, 91100.
Magnus, O., and Lammers, H. J. (1956). ‘The amygdaloid-nuclear complex.Folia Psychiatrica, Neurologica Pet Neurochirurgica Neerlandica, 59, 555–82.
McKissock, W. (1959). ‘Discussion on psychosurgery.Proceedings of the Royal Society of Medicine, 52, 206–9.
Nauta, W. J. H. (1961). ‘Fibre degeneration following lesions of the amygdaloid complex in the monkey.Journal of Anatomy (London), 95, 515–31.
Nauta, W. J. H. (1971). ‘The problem of the frontal lobe: a reinterpretation.Journal of Psychiatric Research, 8, 167–87.
Papez, J. W. (1937). ‘A proposed mechanism of emotion.Archives of Neurology and Psychiatry, 38, 725–43.
Sano, K. (1966). ‘Sedative stereoencephalotomy-fornicotomy, upper mesencephalic reticulotomy and posteromedial hypothalamotomy’, in Progress in Brain Research (ed. Tokizane, T., and Schadé, J. P.). Amsterdam: Elsevier Publishing Co.
Smith, W. K. (1944). ‘The results of stimulation of the uncus and adjacent portion of the hippocampal gyrus.Federation Proceedings, 3, 43.
Smith, W. K. (1945). ‘Functional significance of the rostral cingular cortex as revealed by its responses to electrical excitation.Journal of Neurophysiology, 8, 241–55.
Ström-Olsen, R., and Carlisle, S. (1971). ‘Bi-frontal stereotactic tractotomy. A follow-up study.British Journal of Psychiatry, 118, 141–54.
Ward, A. A. (1948). ‘The cingular gyrus, area 24.Journal of Neurophysiology, 11, 1323.
Yakovlev, P. I. (1965). Personal communication to Ballantine et al., 1967.

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Stereotactic Limbic Leucotomy: Neurophysiological Aspects and Operative Technique

  • Desmond Kelly (a1), Alan Richardson (a1) and Nita Mitchell-Heggs (a1)
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