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Sodium valproate in psychiatric practice: time for a change in perception

  • David Cunningham Owens (a1)

Summary

Sodium valproate and related preparations have recently undergone regulatory review following concern about effects on the unborn child and doctors' failure to communicate risk. The issues are wider. Valproate is overused in psychiatry based on the false perception that ‘ease’ of use equates to better safety than alternatives. Valproic acid can disrupt fundamental physiological processes, the consequences of which are poorly understood and little discussed in the psychiatric literature. Valproate may be useful in a small number of patients with bipolar disorder but current prescribing patterns are unjustified. Perception needs to change.

Declaration of interest

D.C.O. is psychiatric commissioner on the Commission on Human Medicines and a member of the European Medicines Agency's Scientific Advisory Group on Psychiatry. He chaired the European Medicines Agency's review of the psychiatric use of valproate in pregnancy and women of childbearing potential.

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References

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1Ornoy, A, Weinstein-Fudim, L, Ergaz, Z. Antidepressants, antipsychotics and mood stabilisers in pregnancy: what do we know and how should we treat pregnant women with depression. Birth Defects Res 2017; 109: 933–56.
2Meador, K, Reynolds, MW, Crean, S, Fahrbach, K, Probst, C. Pregnancy outcomes in women with epilepsy: a systematic review and meta-analysis of published pregnancy registries and cohorts. Epilepsy Res 2008; 81: 113.
3Ward, HB, Fromson, JA, Cooper, JJ, De Oliviera, G, Almeida, M. Recommendations for the use of ECT in pregnancy: literature review and proposed clinical protocol. Arch Womens Ment Health 2018; 21: 715–22.
4Abosi, O, Lopes, S, Schmitz, S, Fiedorowicz, JG. Cardiometabolic effects of psychotropic medications. Horm Mol Biol Clin Investig 2018; 36: 115.
5Hu, X, Wang, J, Dong, W, Fang, Q, Hu, L, Liu, C. A meta-analysis of polycystic ovary syndrome in women taking valproate for epilepsy. Epilepsy Res 2011; 97: 7382.

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Sodium valproate in psychiatric practice: time for a change in perception

  • David Cunningham Owens (a1)

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Sodium valproate in psychiatric practice: time for a change in perception

  • David Cunningham Owens (a1)
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