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Pursuing parity: genetic tests for psychiatric conditions in the UK National Health Service

  • David Curtis (a1), Katherine Adlington (a2) and Kamaldeep S. Bhui (a3)

Summary

Schizophrenia and anorexia nervosa were recently added to the list of conditions for which whole genome sequencing might be indicated as part of the 100 000 Genomes Project, reflecting the remarkable recent progress in findings emerging from psychiatric genetics research. Genetic testing methods may offer increased opportunities for diagnosis and estimation of familial risk and could have implications for management and treatment options. They also present ethical and philosophical questions about the role of testing and storage of genetic information. Mental health professionals will need to have a good understanding of this area in order for patients to fully realise the benefits of these advances.

Declaration of Interest

K.S.B. is Editor of the British Journal of Psychiatry.

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Copyright

Corresponding author

Correspondence: David Curtis, University College London, UCL Genetics Institute, Darwin Building, Gower Street, London, WC1E 6BT, UK. Email: d.curtis@ucl.ac.uk

References

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1Singh, T, Walters, JTR, Johnstone, M, Curtis, D, Suvisaari, J, Torniainen, M, et al. The contribution of rare variants to risk of schizophrenia in individuals with and without intellectual disability. Nat Genet 2017; 49: 1167–73.
2Coelewij, L, Curtis, D. Mini-review: update on the genetics of schizophrenia. Ann Hum Genet 2018; 82: 239–43.
3Duncan, L, Yilmaz, Z, Gaspar, H, Walters, R, Goldstein, J, Anttila, V, et al. Significant locus and metabolic genetic correlations revealed in genome-wide association study of anorexia nervosa. Am J Psychiatry 2017; 174: 850–8.
4NHS England. National Genomic Test Directories. NHS England, 2018 (https://www.england.nhs.uk/publication/national-genomic-test-directories/).
5Lowther, C, Merico, D, Costain, G, Waserman, J, Boyd, K, Noor, A, et al. Impact of IQ on the diagnostic yield of chromosomal microarray in a community sample of adults with schizophrenia. Genome Med. BioMed Central 2017; 9: 105.
6Hippman, C, Ringrose, A, Inglis, A, Cheek, J, Albert, AYK, Remick, R, et al. A pilot randomized clinical trial evaluating the impact of genetic counseling for serious mental illnesses. J Clin Psychiatry 2016; 77: e1908.

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Pursuing parity: genetic tests for psychiatric conditions in the UK National Health Service

  • David Curtis (a1), Katherine Adlington (a2) and Kamaldeep S. Bhui (a3)
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