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Propranolol in Schizophrenia

I. Comparison of Propranolol, Chlorpromazine and Placebo

Published online by Cambridge University Press:  29 January 2018

M. Peet ,
M. S. Bethell ,
A. Coates ,
A. K. Khamnee ,
P. Hall ,
S. J. Cooper ,
D. J. King  and
R. A. Yates
M. Peet*
Affiliation:
ICI Ltd, Pharmaceuticals Division, and Clinical Assistant, Parkside Hospital, Macclesfield, Cheshire and St Edward's Hospital, Cheddleton, Leek, Staffordshire
M. S. Bethell
Affiliation:
Parkside Hospital
A. Coates
Affiliation:
Worcester District, Hon. Visiting Research Fellow, University of Aston, Birmingham, Worcester Royal Infirmary, Worcester
A. K. Khamnee
Affiliation:
Worcester District, Hon. Visiting Research Fellow, University of Aston, Birmingham, Worcester Royal Infirmary, Worcester
P. Hall
Affiliation:
Worcester District, Hon. Visiting Research Fellow, University of Aston, Birmingham, Worcester Royal Infirmary, Worcester
S. J. Cooper
Affiliation:
Holywell Hospital, Antrim
D. J. King
Affiliation:
Holywell Hospital, Antrim
R. A. Yates
Affiliation:
Clinical Research Department, ICI Ltd, Pharmaceuticals Division, Alderley Park, Macclesfield, Cheshire
*
∗Presently Consultant Psychiatrist, Walton Hospital, Chesterfield, Derbyshire.
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Summary

Fifty-three hospitalized chronic schizophrenic patients were treated with either propranolol, chlorpromazine or placebo in a double-blind randomized trial for up to three months. Propranolol in a usual dose of 640 mg/day, produced marked cardiovascular effects but no improvement in schizophrenic symptomatology relative to placebo. The effects of chlorpromazine were small and inconsistent.

Type
Papers
Information
The British Journal of Psychiatry , Volume 139 , Issue 2 , August 1981 , pp. 105 - 111
Copyright
Copyright © Royal College of Psychiatrists, 1981 

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Footnotes

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