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Predictors of schizophrenia: Evidence from the Northern Finland 1966 Birth Cohort and other sources

  • Matti Isohanni (a1), Erika Lauronen (a1), Kristiina Moilanen (a1), Irene Isohanni (a1), Liisa Kemppainen (a1), Hannu Koponen (a1), Jouko Miettunen (a1), Pirjo Mäki (a1), Sami Räsänen (a1), Juha Veijola (a1), Pekka Tienari (a1), Karl-Erik Wahlberg (a1) and Graham K. Murray (a2)...

Abstract

Background

Subtle motor, emotional, cognitive and behavioural abnormalities are often present in apparently healthy individuals who later develop schizophrenia, suggesting that some aspects of causation are established before overt psychosis.

Aims

To outline the development of schizophrenia.

Method

We drew on evidence from The Northern Finland 1966 Birth Cohort supplemented by selected findings from other relevant literature.

Results

The main known risk factors in development of schizophrenia are genetic causes, pregnancy and delivery complications, slow neuromotor development, and deviant cognitive and academic performance. However, their effect size and predictive power are small.

Conclusions

No powerful risk factor, premorbid sign or risk indicator has been identified that is useful for the prediction of schizophrenia in the general population.

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Copyright

Corresponding author

Dr Matti Isohannni, Department of Psychiatry, University of Oulu, PO Box 5000, Finland. E-mail: matti.isohanni@oulu.fi

Footnotes

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Paper presented at the Third International Early Psychosis Conference, Copenhagen, Denmark, September 2002.

Declaration of interest

The study was funded by special grants from the Finnish Academy Sigrid Juselius Foundation, the Signe and Ane Gyllenberg Foundation, the Jalmari and Rauha Ahokas Foundation, and Stanley Medical Research Institute.

Footnotes

References

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Predictors of schizophrenia: Evidence from the Northern Finland 1966 Birth Cohort and other sources

  • Matti Isohanni (a1), Erika Lauronen (a1), Kristiina Moilanen (a1), Irene Isohanni (a1), Liisa Kemppainen (a1), Hannu Koponen (a1), Jouko Miettunen (a1), Pirjo Mäki (a1), Sami Räsänen (a1), Juha Veijola (a1), Pekka Tienari (a1), Karl-Erik Wahlberg (a1) and Graham K. Murray (a2)...

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