Skip to main content Accessibility help
×
Home

The Prediction of Chronic Persistent Versus Intermittent Tardive Dyskinesia: A Retrospective Follow-Up Study

  • William M. Glazer (a1), Hal Morgenstern (a2) and John T. Doucette (a3)

Abstract

Relatively little is known about the course of TD in patients continuing to receive neuroleptic medication. In a retrospective follow-up study of 192 patients seen two or more times (average 7.7 visits) over 3–55 months in the Yale Tardive Dyskinesia Clinic, 112 (58%) demonstrated a ‘chronic persistent’ pattern, the remainder an ‘intermittent’ pattern. The most important predictors of chronic persistent TD, using multiple logistic-regression analyses, included increased age and the presence of non-orofacial TD at baseline.

Copyright

Corresponding author

Department of Psychiatry, Yale University School of Medicine, 34 Park Street, New Haven, Connecticut 06519, USA

References

Hide All
Branchey, M. H., Branchey, L. B. & Richardson, M. A. (1981) Effects of neuroleptic adjustment on clinical condition and tardive dyskinesia in schizophrenia patients. American Journal of Psychiatry, 138, 606612.
Casey, D. E. (1985) Tardive dyskinesia: reversible and irreversible. In Dyskinesia – Research and Treatment (eds D. E. Casey et al), pp. 8897. Berlin: Springer-Verlag.
Casey, D. E. & Gardos, G. (1986) Tardive dyskinesia: what is the long-term outcome? In Tardive Dyskinesia and Neuroleptics: From Dogma to Reason (ed. D. E. Casey), pp. 8097. Washington, DC: APA.
Casey, D. E., Povlsen, U. F., Meidahl, B., et al (1986) Neurolepticinduced tardive dyskinesia and parkinsonism: changes during several years of continuing treatment. Psychopharmacology Bulletin, 22, 250253.
Chien, C. P. & Cole, J. O. (1973) Eighteen months follow-up of tardive dyskinesia treated with various catecholamine-related agents. Psychopharmacology Bulletin, 9, 3740.
Crane, G. E. (1967) Tardive dyskinesia in schizophrenia patients treated with psychotropic drugs. Aggressologic, 9, 209216.
Crane, G. E., Naranjo, E. R. & Chase, C. (1971) Motor disorders induced by neuroleptics. Archives of General Psychiatry, 24, 149184.
Gardos, G. & Cole, J. (1983) The prognosis of tardive dyskinesia. Journal of Clinical Psychiatry, 44, 177179.
Gardos, G., Perenyi, A., Cole, J., et al (1988) Seven-year follow-up of tardive dyskinesia in Hungarian outpatients. Neuropsychopharmacology, 1, 169172.
Glazer, W. M. (1986) Notes from a tardive dyskinesia clinic. Yale Psychiatric Quarterly, 8, 415.
Glazer, W. M. (1988) Abnormal Involuntary Movement Scale. In Dictionary of Behavioral Assessment Techniques (eds M. Hersen & A. Bellack), pp. 13. New York: Pergamon.
Glazer, W. M. & Moore, D. C. (1981) A tardive dyskinesia clinic in a mental health center. Hospital and Community Psychiatry, 32, 572574.
Glazer, W. M., Moore, D. C., Schooler, N., et al (1984) Tardive dyskinesia: a discontinuation study. Archives of General Psychiatry, 41, 623627.
Glazer, W. M. & Morgenstern, H. (1988) Predictors of occurrence, severity, and course of tardive dyskinesia in an outpatient population. Journal of Clinical Psychopharmacology, 8, 10S16S.
Glazer, W. M., Morgenstern, H. & Niedzwiecki, D. (1988) Heterogeneity of tardive dyskinesia: a multivariate analysis. British Journal of Psychiatry, 152, 253259.
Glazer, W. M., Morgenstern, H., Schooler, N., et al (1990) Predictors of improvement in tardive dyskinesia following discontinuation of neuroleptic medication. British Journal of Psychiatry, 157, 585592.
Granacher, R. (1981) Differential diagnosis of tardive dyskinesia: an overview. American Journal of Psychiatry, 138, 12881297.
Guy, W. (1976) ECDEU Assessment Manual for Psychopharmacology (revised 1976). US Department of Health, Education and Welfare Publication 76–338. Washington, DC: ADAMHA.
Hollingshead, A. (1975) A Two Factored Index of Social Position (mimeographed booklet). New Haven: Yale University Press.
Hollister, L. E. (1977) Anti-psychotic medications and the treatment of schizophrenia. In Psychopharmacology: From Theory to Practice (eds J. D. Barchas, et al), pp. 121150. New York: Oxford University Press.
Jeste, D. & Wyatt, R. (1981) Changing epidemiology of tardive dyskinesia. American Journal of Psychiatry, 138, 297309.
Jeste, D. & Wyatt, R. (1982) Understanding and Treating Tardive Dyskinesia. New York: Guilford Press.
Kleinbaum, D., Kupper, L. & Morgenstern, H. (1982) Epidemiologic Research: Principles and Quantitative Methods. Belmont: Lifetime Learning.
Lane, R., Glazer, W. & Hansen, T. (1985) Assessment of tardive dyskinesia using the abnormal involuntary movement scale. Journal of Nervous and Mental Disorder, 173, 353357.
Morgenstern, H., Glazer, W., Gibowski, L., et al (1987a) Predictors of tardive dyskinesia: results of a cross-sectional study in an outpatient population. Journal of Chronic Disorders, 40, 319327.
Morgenstern, H., Glazer, W., Niedzwiecki, D., et al (1987b) The impact of neuroleptic medication on tardive dyskinesia: a meta-analysis of published studies. American Journal of Public Health, 77, 717724.
Schonecker, M. (1957) Eig eigentumliches syndrom in oralen Bereich bei megaphen applikation. Nervenzart, 28, 3546.
Schooler, N. & Kane, J. (1982) Research diagnoses for tardive dyskinesia. Archives of General Psychiatry, 39, 486487.
Seeman, M. V. (1981) Tardive dyskinesia: two-year recovery. Comparative Psychiatry, 22, 189192.
Smith, J. M. & Baldessarini, R. J. (1980) Changes in prevalence, severity and recovery in tardive dyskinesia with age. Archives of General Psychiatry, 37, 13681373.
Smith, J. M., Burke, M. P. & Moon, C. O. (1981) Long-term changes in AIMS ratings and their relation to medication history. Psychopharmacology Bulletin, 17, 120121.
Spitzer, R. & Endicott, J. (1978) Schedule for Affective Disorders and Schizophrenia – Lifetime Version (SADS–L) (3rd edn). New York: New York State Psychiatric Institute.
Spitzer, R., Endicott, J. & Robins, E. (1978) Research diagnostic criteria: rationale and reliability. Archives of General Psychiatry, 35, 773782.
Turek, I., Kurland, A. A., Hanlon, T. E., et al (1972) Tardive dyskinesia: its relation to neuroleptic and antiparkinson drugs. British Journal of Psychiatry, 121, 605612.
Uhrbrand, L. & Faurbye, A. (1960) Reversible and irreversible dyskinesia after treatment with perphenazine, chlorpromazine, reserpine, and electroconvulsive therapy. Psychopharmacologia, 1, 408448.
Waddington, J. L. (1989) Schizophrenia, affective psychoses, and other disorders treated with neuroleptic drugs: the enigma of tardive dyskinesia, its neurobiological determinants, and the conflict of paradigms. International Review of Neurobiology, 31, 297353.
Wegner, J. T. & Kane, J. M. (1982) Follow-up study on the reversibility of tardive dyskinesia. American Journal of Psychiatry, 139, 368369.
Yagi, G. & Itoh, H. (1987) Follow-up study of 11 patients with potentially reversible tardive dyskinesia. American Journal of Psychiatry, 144, 14961498.
Yassa, R., Nair, V. & Schwartz, G. (1984) Tardive dyskinesia: a two-year follow-up. Psychosomatics, 25, 852855.

The Prediction of Chronic Persistent Versus Intermittent Tardive Dyskinesia: A Retrospective Follow-Up Study

  • William M. Glazer (a1), Hal Morgenstern (a2) and John T. Doucette (a3)

Metrics

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed

The Prediction of Chronic Persistent Versus Intermittent Tardive Dyskinesia: A Retrospective Follow-Up Study

  • William M. Glazer (a1), Hal Morgenstern (a2) and John T. Doucette (a3)
Submit a response

eLetters

No eLetters have been published for this article.

×

Reply to: Submit a response


Your details


Conflicting interests

Do you have any conflicting interests? *